Main Fabio’s PhD work preprint is out!

Excited to share our new study, now out on bioRxiv: https://www.biorxiv.org/content/10.64898/2026.05.05.722849v1

In this work, we identify CK1α as a novel positive regulator of NOTCH1 signaling and uncover a previously unknown phosphorylation-dependent regulatory mechanism centered on N1ICD residue S1970. By combining cell biology, structural modeling, NMR, mass spectrometry, and Xenopus in vivo assays, we show how CK1α activity supports assembly of the active NOTCH1 transcriptional complex.

Special thanks to Fabio Turetti, and Hanka Hajsmanova who drove this project with exceptional persistence and creativity, Jakub Harnoš Lab for their tremendous support and collaboration throughout the study, and everyone else helping us along the way!