Prof. Dr. Carolyn King
The King lab investigates CD4 T cell responses in barrier tissues, with a specific focus on the formation and impact of CD4 T cells that support antibody production by B cells. Using a combination of single-cell and systems immunology approaches we are addressing the biological underpinnings and therapeutic potential of mucosal immunity to combat globally relevant pathogens including influenza and tuberculosis.
Papers: T resident helper cells promote humoral responses in the lung
Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity
Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection
Prof. Dr. Nicole Joller
The Joller lab focuses on understanding the host-pathogen interaction and investigating the long-term effects of pathogenic challenges on future responses. Currently, they are analyzing the regulatory T cell compartment in infection and how its changes affect the susceptibility to infection and much more. To decipher this topic, they use a wide variety of techniques including transcriptomics, high dimensional flow cytometry, in vitro and in vivo immunological assays, and animal models (infectious and autoimmune).
Papers: Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
Lag-3, Tim-3, and TIGIT: Co-inhibitory receptors with specialized functions in immune regulation
TIGIT limits immune pathology during viral infections
Prof. Dr. Graham Anderson
Grahams research focus is thymus biology. Early in his career, he established new approaches to study thymus function within defined three-dimensional reaggregate cultures. This experimental system is now used worldwide as a cornerstone technique of thymus research.
Most recently, his studies highlight how thymic epithelial subtypes regulate qualitatively different T-cell subsets, and control pregnancy success. Finally, his work identifying an intra-thymic innate cell network that drives thymus regeneration, and selective failures in thymus function post bone marrow transplant, offer clinically tractable targets to effective immune reconstitution.
Papers: Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration
Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells