Manipulation hypothesis?
- Of course, a modern man represents a rather aberrant intermediate host for the parasite. There is really only minimal chance for the Toxoplasma to force its human host to be eaten by the definitive host the cat. Therefore, the manipulation activity in human is nonproductive, cannot be a subject of natural selection and the induced changes in human behavior would be probably nonspecific and nonadaptive. However, there are indications that in the rodent models the mechanisms of manipulation activity probably involves the production of some neurotransmitter (possibly dopamine) in the brain tissue. Such changes in the level of neurotransmitter could be reflected by changes in personality profile or behavior of the subject.