1340h
AN: B33C-1426
TI: Magnetic Analysis of Post-mortem
Hippocampal Tissue from Alzheimer's Patients: Changes with Progression
of the Disease.
AU: * Fuller, M
EM: mfuller@soest.hawaii.edu
AF: HIGP-SOEST., University of Hawaii at
Manoa, Honolulu, HI 96822, United States
AU: Zinin, P
EM: zini@soest.hawaii.edu
AF: HIGP-SOEST., University of Hawaii at
Manoa, Honolulu, HI 96822, United States
AU: Favia, J
EM: favia@hawaii.edu
AF: HIGP-SOEST., University of Hawaii at
Manoa, Honolulu, HI 96822, United States
AU: Tatsumi, L
EM: lisa.tatsumi@gmail.com
AF: HIGP-SOEST., University of Hawaii at
Manoa, Honolulu, HI 96822, United States
AU: Kletetschka, G
EM: gunther.kletetschka@gsfc.nasa.gov
AF: Geology, Charles University, Prague,
12843, Czech Republic
AU: Kletetschka, G
EM: gunther.kletetschka@gsfc.nasa.gov
AF: Physics, Catholic University of America,
Washington, DC 20064, United States
AU: Kletetschka, G
EM: gunther.kletetschka@gsfc.nasa.gov
AF: Astrochemistry, GSFC/NASA, Code 691,
Greenbelt, MD 96822, United States
AU: Adachi, T
EM: tomoko.adachi@ssedmail.gsfc.nasa.gov
AF: Astrochemistry, GSFC/NASA, Code 691,
Greenbelt, MD 96822, United States
AB:
Increases of iron in the human brain with age have been observed and
may be accompanied by the development
of neurodegenerative diseases, such as Alzheimer's. We have measured
the magnetic characteristics of several
sets of slides of hippocampal tissue from deceased Alzheimer patients.
The slides were made available by the
Harvard Brain Bank. The pathology of the tissue was classified in the
Braak stages I to VI used to describe the
progression of the disease. In general, the slides from patients with
higher Braak stages and development of
fibrillary tangles and plaques had greater magnetic moments than did
those with Braak stage II. However, the
peak values were at stage IV and V. To mitigate errors due to the
inevitable differences in masses of the tissue on individual slides and
their precise location in the hippocampus, ratios of magnetic
properties were also
observed. Ratios of Anhysteretic Remanent Magnetizaton (ARM) to
Isothermal Remanent Magnetization (IRM)
were obtained and showed a decrease from Stage II to the more advanced
stages, with the minimum values at
stages IV and V. The acquisition and demagnetization of IRM are
consistent with the presence of magnetite, but
also indicate a magnetically harder phase.
DE: 1505 Biogenic magnetic minerals
SC: Biogeosciences [B]
MN: 2007 Fall Meeting