{"id":4928,"date":"2021-01-20T09:52:46","date_gmt":"2021-01-20T08:52:46","guid":{"rendered":"https:\/\/ukazky.euweb.cz\/?page_id=4928"},"modified":"2025-04-02T12:19:48","modified_gmt":"2025-04-02T12:19:48","slug":"projects-and-grants","status":"publish","type":"page","link":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/projects-and-grants\/","title":{"rendered":"Projects & Grants"},"content":{"rendered":"\n
\n
\n
<\/div>\n\n\n\n

Currently running<\/h2>\n\n\n\n
<\/div>\n\n\n\n
\n<\/div><\/div>\n\n\n\n
\n

Elucidation of the interaction of the rat NK cell receptor NKR-P1B with its ligands of natural and viral origin by DNA-PAINT and protein crystallography<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> J. Jen\u00ed\u010dek<\/p>\n\n\n\n

Grantor: <\/strong>Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2025 – 2027<\/p>\n\n\n\n

Grant number:<\/strong> 470225<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Exploiting molecular mechanisms of natural killer cell recognition for antitumor therapy<\/strong><\/h4>\n\n\n\n

<\/p>\n\n\n\n

<\/div>\n\n\n\n

Principal investigator:<\/strong> O. Van\u011bk<\/p>\n\n\n\n

Co-investigators:<\/strong> Dr. Grzegorz Piszczek, National Heart, Lung, and Blood Institute, NIH, Bethesda, USA<\/p>\n\n\n\n

Grantor: <\/strong>Ministry of Education, Youth and Sports of the Czech Republic, INTER-ACTION program<\/p>\n\n\n\n

Duration:<\/strong> 2025 – 2028<\/p>\n\n\n\n

Grant number:<\/strong> LUAUS25250<\/p>\n\n\n\n

<\/div>\n<\/div><\/div>\n\n\n\n
\n

Structural immunology of NK cell recognition: from tumor evasion to its eradication<\/strong><\/h4>\n\n\n\n

<\/p>\n\n\n\n

<\/div>\n\n\n\n

Principal investigator:<\/strong> O. Van\u011bk<\/p>\n\n\n\n

Grantor: <\/strong>Czech Science Foundation<\/p>\n\n\n\n

Duration:<\/strong> 2025 – 2027<\/p>\n\n\n\n

Grant number:<\/strong> 25-18490S<\/p>\n\n\n\n

<\/div>\n<\/div><\/div>\n\n\n\n
\n

A New Vision: Innovative Imaging Approaches for Investigating the Spatial Organization of
Immune Receptors and Ligands<\/strong><\/h4>\n\n\n\n

<\/p>\n\n\n\n

<\/div>\n\n\n\n

Principal investigator:<\/strong> O. Sko\u0159epa<\/p>\n\n\n\n

Hosts:<\/strong> Prof. Dr. Ralf Jungmann, Prof. Dr. Petra Schwille, Max Planck Institute of Biochemistry, Germany<\/p>\n\n\n\n

Grantor: <\/strong>Czech Science Foundation<\/p>\n\n\n\n

Duration:<\/strong> 2024 – 2027<\/p>\n\n\n\n

Grant number:<\/strong> 24-12553O<\/p>\n\n\n\n

<\/div>\n<\/div><\/div>\n\n\n\n
\n

Nanoscale organisation of NK cell receptor-ligand complexes through the optics of
quantitative single-molecule microscopy<\/strong><\/h4>\n\n\n\n

<\/p>\n\n\n\n

<\/div>\n\n\n\n

Principal investigator:<\/strong> O. Van\u011bk<\/p>\n\n\n\n

Co-investigators:<\/strong> Dr. Mario Brameshuber, Technical University of Vienna, Austria<\/p>\n\n\n\n

Co-investigators:<\/mark><\/strong> assoc. prof. Ario de Marco, University Nova Gorica, Slovenia<\/p>\n\n\n\n

Grantor: <\/strong>Czech Science Foundation<\/p>\n\n\n\n

Duration:<\/strong> 2023 – 2026<\/p>\n\n\n\n

Grant number:<\/strong> 23-08490L<\/p>\n\n\n\n

<\/div>\n<\/div><\/div>\n\n\n\n
\n

Novel recombinant immunocytokines to stimulate the anti-tumour immune response<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> N. Bragina<\/p>\n\n\n\n

Grantor: <\/strong>Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2023 – 2025<\/p>\n\n\n\n

Grant number:<\/strong> 285423<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Utilising sortase A for the preparation of polymer immunotherapeutics and determining their antitumour activity<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> M. Hejl<\/p>\n\n\n\n

Grantor: <\/strong>Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2023 – 2025<\/p>\n\n\n\n

Grant number:<\/strong> 173923<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

<\/div>\n\n\n\n

Past<\/h2>\n\n\n\n
\n\n\n\n
\n

Activation receptor NKp80 and its ligand AICL: structure and mutual interaction in solution and on the surface of human NK cells<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> K. Pazderov\u00e1<\/p>\n\n\n\n

Grantor: <\/strong>Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2022 – 2024<\/p>\n\n\n\n

Grant number:<\/strong> 318122<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Interaction of galectin-3 with the NKp30 receptor and its role in the antitumor immune response<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> M. Tulpa<\/p>\n\n\n\n

Grantor: <\/strong>Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2022 – 2024<\/p>\n\n\n\n

Grant number:<\/strong> 358322<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Glycan-dependent regulation of NK cell recognition: structural biology and novel methods of glycopeptide analysis<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> O. Van\u011bk<\/p>\n\n\n\n

Grantor:<\/strong> Ministry of Education, Youth and Sports of the Czech Republic, INTER-COST program<\/p>\n\n\n\n

Duration:<\/strong> 2020 – 2023<\/p>\n\n\n\n

Grant number:<\/strong> LTC20078<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Activation of NK cell anti-tumour response using bispecific fusion proteins with nanobodies<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> C. Abreu<\/p>\n\n\n\n

Grantor: <\/strong>Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2020 – 2022<\/p>\n\n\n\n

Grant number:<\/strong> 1436220<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Structural biochemistry of NK cell complexes NKp44:PCNA and NKp46:Epa1, and utilization of Epa1 for stimulation of NK cells<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> J. Houserov\u00e1<\/p>\n\n\n\n

Grantor:<\/strong> Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2020 – 2022<\/p>\n\n\n\n

Grant number:<\/strong> 1436020<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Novel clinically relevant IL-2 immunotherapeutics for cancer treatment<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> O. Van\u011bk (co-investigator)<\/p>\n\n\n\n

Grantor:<\/strong> Czech Science Foundation<\/p>\n\n\n\n

Duration:<\/strong> 2020 – 2022<\/p>\n\n\n\n

Grant number:<\/strong> 20-13029S<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Quaternary structure of selected human lymphocyte receptors through the looking glass of super-resolution microscopy: What is the biological reality behind the crystal structures?<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> B. Kalouskov\u00e1<\/p>\n\n\n\n

Grantor:<\/strong> Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2019 – 2021<\/p>\n\n\n\n

Grant number:<\/strong> 1378219<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Utilization of activation ligands and nanobodies for directed stimulation of NK cells cytotoxicity<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> D. Cmunt<\/p>\n\n\n\n

Grantor:<\/strong> Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong>  2018 – 2019<\/p>\n\n\n\n

Grant number:<\/strong> 1740318 <\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

New ligands for old receptors of human natural killer cells: structure, assembly within the immune synapse and potential for therapy<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> O. Van\u011bk<\/p>\n\n\n\n

Grantor:<\/strong> Czech Science Foundation<\/p>\n\n\n\n

Duration:<\/strong> 2018 – 2021<\/p>\n\n\n\n

Grant number:<\/strong> 18-10687S<\/p>\n<\/div>\n<\/div>\n\n\n\n

Utilization of integrative molecular biophysical approaches for the functional studies of human natural killer cell receptors and formation of their complexes with tumour ligands<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> O. Van\u011bk<\/p>\n\n\n\n

Grantor:<\/strong> Ministry of Education, Youth and Sports of the Czech Republic, INTER-COST program<\/p>\n\n\n\n

Duration:<\/strong> 2017 – 2020<\/p>\n\n\n\n

Grant number:<\/strong> LTC17065<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Impact of NKp30 glycosylation and oligomerization on its complex formation – the key features for NK cells activation<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> S. Pa\u017eick\u00fd \/ O. Sko\u0159epa<\/p>\n\n\n\n

Grantor:<\/strong> Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2016 – 2018<\/p>\n\n\n\n

Grant number:<\/strong> 927916<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Utilization of a structural description of the interaction of human lymphocyte complex NKR-P1 and LLT1 for development of immunoactive fusion therapeutics<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> J. Bl\u00e1ha \/ B. Kalouskov\u00e1<\/p>\n\n\n\n

Grantor:<\/strong> Grant Agency of the Charles University<\/p>\n\n\n\n

Duration:<\/strong> 2016 – 2018<\/p>\n\n\n\n

Grant number:<\/strong> 161216<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n

Harnessing soluble forms of NK cell receptors and their ligands for the generation of novel anticancer immunotherapeutics<\/strong><\/h4>\n\n\n\n
<\/div>\n\n\n\n
\n
\n

Principal investigator:<\/strong> O. Van\u011bk<\/p>\n\n\n\n

Grantor:<\/strong> Czech Science Foundation<\/p>\n\n\n\n

Duration:<\/strong> 2015 – 2017<\/p>\n\n\n\n

Grant number:<\/strong> 15-15181S<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

<\/div>\n\n\n\n
\n
<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Currently running Elucidation of the interaction of the rat NK cell receptor NKR-P1B with its ligands of natural and viral origin by DNA-PAINT and protein crystallography Principal investigator: J. Jen\u00ed\u010dek Grantor: Grant Agency of the Charles University Duration: 2025 – 2027 Grant number: 470225 Exploiting molecular mechanisms of natural killer cell recognition for antitumor therapy […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-4928","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"structimmuno","author_link":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/author\/structimmuno\/"},"uagb_comment_info":0,"uagb_excerpt":"Currently running Elucidation of the interaction of the rat NK cell receptor NKR-P1B with its ligands of natural and viral origin by DNA-PAINT and protein crystallography Principal investigator: J. Jen\u00ed\u010dek Grantor: Grant Agency of the Charles University Duration: 2025 – 2027 Grant number: 470225 Exploiting molecular mechanisms of natural killer cell recognition for antitumor therapy…","_links":{"self":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/pages\/4928","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/comments?post=4928"}],"version-history":[{"count":4,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/pages\/4928\/revisions"}],"predecessor-version":[{"id":7644,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/pages\/4928\/revisions\/7644"}],"wp:attachment":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/media?parent=4928"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}