{"id":7507,"date":"2024-09-30T14:24:00","date_gmt":"2024-09-30T14:24:00","guid":{"rendered":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/?p=7507"},"modified":"2025-09-24T11:50:53","modified_gmt":"2025-09-24T11:50:53","slug":"our-research-featured-on-the-jci-insight-journals-cover","status":"publish","type":"post","link":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/our-research-featured-on-the-jci-insight-journals-cover\/","title":{"rendered":"Our research featured on the JCI Insight journal&#8217;s cover"},"content":{"rendered":"\n<div class=\"wp-block-media-text is-stacked-on-mobile is-vertically-aligned-center\" style=\"grid-template-columns:42% auto\"><figure  class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"402\" alt=\"\" src=\"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover.jpg\" class=\"wp-image-7509 size-full\" srcset=\"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover.jpg 300w, https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover-224x300.jpg 224w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\"><strong>Our research has been featured on the front cover of the <em>JCI Insight<\/em> journal (Volume 9, Issue 18, published on 24th September 2024).<\/strong> The image highlights our work on <strong>IL-2 immunocytokines<\/strong>, showcasing their potential for targeted immune modulation. This recognition underscores the significance of our findings in <strong>cytokine engineering and immune therapy<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This study is part of a <strong>Czech Science Foundation-funded project on IL-2 immunocytokines<\/strong>, which recently received an <strong>&#8220;excellent&#8221; rating<\/strong>. The research contributes to the growing field of <strong>precision immunotherapy<\/strong>, focusing on improving <strong>IL-2 delivery to immune effector cells<\/strong> for safer and more effective cancer treatment.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-cyan-bluish-gray-color has-text-color has-link-color wp-elements-1 wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1172\/jci.insight.173469\" data-type=\"link\" data-id=\"https:\/\/doi.org\/10.1172\/jci.insight.173469\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-cyan-blue-color\">Leonard, E. K.; Tomala, J.; Gould, J. R.; Leff, M. I.; Lin, J.-X.; Li, P.; Porter, M. J.; Johansen, E. R.; Thompson, L.; Cao, S. D.; Hou, S.; Henclova, T.; Huliciak, M.; Sargunas, P. R.; Fabilane, C. S.; Van\u011bk, O.; Kovar, M.; Schneider, B.; Raimondi, G.; Leonard, W. J.; Spangler, J. B. (2024): <strong>Engineered Cytokine\/Antibody Fusion Proteins Improve IL-2 Delivery to pro-Inflammatory Cells and Promote Antitumor Activity.<\/strong> <em>JCI Insight<\/em> 9, e173469. <strong>IF 6.3<\/strong> DOI: 10.1172\/jci.insight.173469.<\/mark><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our research has been featured on the front cover of the JCI Insight journal (Volume 9, Issue 18, published on 24th September 2024). The image highlights our work on IL-2 immunocytokines, showcasing their potential for targeted immune modulation. This recognition underscores the significance of our findings in cytokine engineering and immune therapy. This study is [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7509,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-7507","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"uagb_featured_image_src":{"full":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover.jpg",300,402,false],"thumbnail":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover-150x150.jpg",150,150,true],"medium":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover-224x300.jpg",224,300,true],"medium_large":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover.jpg",300,402,false],"large":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover.jpg",300,402,false],"1536x1536":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover.jpg",300,402,false],"2048x2048":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2024\/09\/JCI_Insight_173469_cover.jpg",300,402,false]},"uagb_author_info":{"display_name":"structimmuno","author_link":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/author\/structimmuno\/"},"uagb_comment_info":0,"uagb_excerpt":"Our research has been featured on the front cover of the JCI Insight journal (Volume 9, Issue 18, published on 24th September 2024). The image highlights our work on IL-2 immunocytokines, showcasing their potential for targeted immune modulation. This recognition underscores the significance of our findings in cytokine engineering and immune therapy. This study is&hellip;","_links":{"self":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/posts\/7507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/comments?post=7507"}],"version-history":[{"count":17,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/posts\/7507\/revisions"}],"predecessor-version":[{"id":7774,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/posts\/7507\/revisions\/7774"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/media\/7509"}],"wp:attachment":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/media?parent=7507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/categories?post=7507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/tags?post=7507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}