{"id":7524,"date":"2024-12-01T11:26:00","date_gmt":"2024-12-01T11:26:00","guid":{"rendered":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/?p=7524"},"modified":"2025-03-21T09:08:16","modified_gmt":"2025-03-21T09:08:16","slug":"new-czech-science-foundation-project-on-structural-immunology-of-nk-cell-recognition","status":"publish","type":"post","link":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/new-czech-science-foundation-project-on-structural-immunology-of-nk-cell-recognition\/","title":{"rendered":"New Czech Science Foundation project on structural immunology of NK cell recognition"},"content":{"rendered":"\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile\" style=\"grid-template-columns:auto 37%;\">\n    <div class=\"wp-block-media-text__content\">\n        <p style=\"display: block !important; margin-bottom: 15px !important; font-size: 16px !important; line-height: 1.6 !important;\">\n            A new project, called <em><span style=\"color: darkred !important;\">Structural Immunology of NK Cell Recognition: From Tumour Evasion to Its Eradication<\/span><\/em>, \n            led by <strong>Ond\u0159ej Van\u011bk<\/strong>, has been awarded funding by the <strong>Czech Science Foundation (GA \u010cR)<\/strong>. \n            Running from 2025 to 2027 (Grant No. <strong>25-18490S<\/strong>), this study aims to advance our understanding of \n            <strong>NK cell-mediated immune responses<\/strong> at the structural level.\n        <\/p>\n    <\/div>\n    <figure class=\"wp-block-media-text__media\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"344\" height=\"125\" src=\"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr.png\" alt=\"\" class=\"wp-image-7527 size-full\" srcset=\"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr.png 344w, https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr-300x109.png 300w\" sizes=\"auto, (max-width: 344px) 100vw, 344px\" \/>\n    <\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:47% auto;\">\n    <figure class=\"wp-block-media-text__media\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"857\" src=\"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/Siglec-7_FED_Image_2615_H2_Drop3-1024x857.png\" alt=\"\" class=\"wp-image-7525 size-full\" srcset=\"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/Siglec-7_FED_Image_2615_H2_Drop3-1024x857.png 1024w, https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/Siglec-7_FED_Image_2615_H2_Drop3-300x251.png 300w, https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/Siglec-7_FED_Image_2615_H2_Drop3-768x643.png 768w, https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/Siglec-7_FED_Image_2615_H2_Drop3.png 1090w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>\n    <\/figure>\n    <div class=\"wp-block-media-text__content\">\n        <p style=\"display: block !important; margin-bottom: 15px !important; font-size: 16px !important; line-height: 1.6 !important;\">\n            The project will use <strong>advanced structural biology techniques<\/strong> to focus on key \n            <strong>NK cell receptors and their ligands<\/strong>, including <strong>NKp80:AICL, CD69:Galectin-1, Siglec-7, and NKR-P1C<\/strong>. \n            Our researchers will characterise these protein interactions, identify <strong>unknown ligands<\/strong>, and determine their roles in \n            <strong>tumour recognition versus immune evasion<\/strong>. Additionally, the study will explore <strong>microbial immune evasion mechanisms<\/strong> \n            linked to <strong>Fusobacterium nucleatum<\/strong> and tumourigenesis.\n        <\/p>\n    <\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"display: block !important; margin-bottom: 15px !important; font-size: 16px !important; line-height: 1.6 !important;\">\n    This research is expected to contribute to the <strong>rational design of novel immunotherapies<\/strong>, such as \n    <strong>bispecific killer engagers<\/strong> and <strong>CAR-NK cells<\/strong>, enhancing their efficacy in targeting resistant cancers.\n<\/p>\n\n","protected":false},"excerpt":{"rendered":"<p>A new project, called Structural Immunology of NK Cell Recognition: From Tumour Evasion to Its Eradication, led by Ond\u0159ej Van\u011bk, has been awarded funding by the Czech Science Foundation (GA \u010cR). Running from 2025 to 2027 (Grant No. 25-18490S), this study aims to advance our understanding of NK cell-mediated immune responses at the structural level. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7527,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[17],"tags":[],"class_list":["post-7524","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-projects"],"uagb_featured_image_src":{"full":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr.png",344,125,false],"thumbnail":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr-150x125.png",150,125,true],"medium":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr-300x109.png",300,109,true],"medium_large":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr.png",344,125,false],"large":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr.png",344,125,false],"1536x1536":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr.png",344,125,false],"2048x2048":["https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-content\/uploads\/2025\/03\/gacr.png",344,125,false]},"uagb_author_info":{"display_name":"structimmuno","author_link":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/author\/structimmuno\/"},"uagb_comment_info":0,"uagb_excerpt":"A new project, called Structural Immunology of NK Cell Recognition: From Tumour Evasion to Its Eradication, led by Ond\u0159ej Van\u011bk, has been awarded funding by the Czech Science Foundation (GA \u010cR). Running from 2025 to 2027 (Grant No. 25-18490S), this study aims to advance our understanding of NK cell-mediated immune responses at the structural level.&hellip;","_links":{"self":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/posts\/7524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/comments?post=7524"}],"version-history":[{"count":15,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/posts\/7524\/revisions"}],"predecessor-version":[{"id":7578,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/posts\/7524\/revisions\/7578"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/media\/7527"}],"wp:attachment":[{"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/media?parent=7524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/categories?post=7524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/biochem\/structimmuno\/wp-json\/wp\/v2\/tags?post=7524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}