{"id":4983,"date":"2021-01-20T11:45:32","date_gmt":"2021-01-20T10:45:32","guid":{"rendered":"https:\/\/ukazky.euweb.cz\/?page_id=4983"},"modified":"2025-11-02T20:19:04","modified_gmt":"2025-11-02T20:19:04","slug":"publications","status":"publish","type":"page","link":"https:\/\/web.natur.cuni.cz\/cellbiol\/dobeslab\/publications\/","title":{"rendered":"List of publications"},"content":{"rendered":"\n<div class=\"wp-block-columns are-vertically-aligned-center researcher-ID is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<span id=\"badgeCont304\"><script type=\"text\/javascript\" src=\"https:\/\/publons.com\/mashlets?el=badgeCont304&amp;rid=AAL-1287-2020\"><\/script><\/span>\n\n\n\n<p><strong>Selected publications:<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-left\"><strong>Segmented filamentous bacteria\u2013induced epithelial MHCII regulates cognate CD4<sup>+<\/sup> IELs and epithelial turnover<\/strong><br><em>Authors:<\/em> <strong>Tom\u00e1\u0161 Brabec<\/strong>, Martin Schwarzer, <strong>Katar\u00edna Kov\u00e1\u010dov\u00e1<\/strong>, <strong>Martina Dobe\u0161ov\u00e1<\/strong>, Dagmar Schierov\u00e1, Ji\u0159\u00ed B\u0159ezina, <strong>Iva Pac\u00e1kov\u00e1<\/strong>, Dagmar \u0160r\u016ftkov\u00e1, Osher Ben-Nun, Yael Goldfarb, Iva \u0160pl\u00edchalov\u00e1, Michal Kol\u00e1\u0159, Jakub Abramson, Dominik Filipp and <strong>Jan Dobe\u0161<\/strong><br><em>Published:<\/em> 2023 <em>in<\/em> <strong>Journal of Experimental Medicine<\/strong><br>DOI: <a href=\"https:\/\/doi.org\/10.1084\/jem.20230194\">10.1084\/jem.20230194<\/a><\/p>\n\n\n\n<p class=\"has-text-align-left\"><br><strong>The emerging family of ROR\u03b3t<sup>+<\/sup> antigen-presenting cells<\/strong><br><em>Authors:&nbsp;<\/em>Jakub Abramson*, <strong>Jan Dobe\u0161<\/strong>*, Mengze Lyu*, Gregory F. Sonnenberg*<br><em>Published:&nbsp;<\/em>2023<em>&nbsp;in&nbsp;<\/em><strong>Nature Reviews Immunology<\/strong><br><em>DOI:&nbsp;<\/em><a href=\"https:\/\/doi.org\/10.1038\/s41577-023-00906-5\">10.1038\/s41577-023-00906-5005<\/a><br>*all authors contributed equally<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-text-align-left\"><strong>Extrathymic expression of Aire controls the induction of effective T<sub>H<\/sub>17 cell-mediated immune response to <em>Candida albicans<\/em><\/strong><br><em>Authors:&nbsp;<\/em><strong>Jan Dobe\u0161<\/strong>, Osher Ben-Nun, Amit Binyamin, Liat Stoler-Barak, Bergithe E. Oftedal, Yael Goldfarb, Noam Kadouri, Yael Gruper, Tal Givony, Itay Zalayat, <strong>Katar\u00edna Kov\u00e1\u010dov\u00e1<\/strong>, <strong>Helena B\u00f6hmov\u00e1<\/strong>, <strong>Evgeny Valter<\/strong>, Ziv Shulman, Dominik Filipp, Eystein S. Husebye, Jakub Abramson<br><em>Published:&nbsp;<\/em>2022<em>&nbsp;in&nbsp;<\/em><strong>Nature Immunology<\/strong><br><em>DOI:&nbsp;<\/em><a href=\"https:\/\/www.nature.com\/articles\/s41590-022-01247-6\">10.1038\/s41590-022-01247-6<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-faq uagb-faq__outer-wrap uagb-block-32a4cf19 uagb-faq-icon-row uagb-faq-layout-accordion uagb-faq-expand-first-true uagb-faq-inactive-other-true uagb-faq__wrap uagb-buttons-layout-wrap uagb-faq-equal-height\" data-faqtoggle=\"true\" role=\"tablist\"><script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"@id\":\"https:\/\/web.natur.cuni.cz\/cellbiol\/dobeslab\/publications\/\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"2025\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"&lt;strong>Dietary influence and immune balance: Regulating CD4+ IEL responses and MHCII in the gut&lt;\/strong>&lt;br>&lt;em>Authors:&lt;\/em> &lt;strong>Jan Dobe\u0161&lt;\/strong>, &lt;strong>Tom\u00e1\u0161 Brabec&lt;\/strong>&lt;br>&lt;em>Published:&lt;\/em> 2025 &lt;em>in&lt;\/em> &lt;strong>Mucosal Immunology&lt;\/strong>&lt;br>DOI: &lt;a href=\\\"https:\/\/doi.org\/10.1016\/j.mucimm.2024.12.011\\\">https:\/\/doi.org\/10.1016\/j.mucimm.2024.12.011&lt;\/a>&lt;br>&lt;br>&lt;strong>CUL4A exhibits tumor-suppressing role via regulation of HUWE1-mediated SMAD3 intracellular shuttling&lt;\/strong>&lt;br>&lt;em>Authors:&lt;\/em> Veronika Danek, Jolana Tureckova, Kerstin Huebner, Katharina Erlenbach-Wuensch, Petra Baranova, &lt;strong>Jan Dobes&lt;\/strong>, Jana Balounova, Michaela Simova, Vendula Novosadova, Carlos Eduardo Madureira Trufen, Michaela Prochazkova, Pavel Talacko, Karel Harant, Cyril Barinka, Inken M Beck, Regine Schneider-Stock, Radislav Sedlacek, Jan Prochazka&lt;br>&lt;em>Published:&lt;\/em> 2025 &lt;em>in&lt;\/em> &lt;strong>Cancer Letters&lt;\/strong>&lt;br>DOI: &lt;a href=\\\"https:\/\/doi.org\/10.1016\/j.canlet.2025.217663\\\">https:\/\/doi.org\/10.1016\/j.canlet.2025.217663 &lt;\/a>\"}},{\"@type\":\"Question\",\"name\":\"2024\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"&lt;strong>Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects&lt;\/strong>&lt;br>&lt;em>Authors:&lt;\/em> Jan Ma\u0161ek, Iva Filipovic, No\u00e9mi Van Hul, Lenka Belicov\u00e1, Mark\u00e9ta Jirou\u0161kov\u00e1, Daniel V Oliveira, Anna Maria Frontino, Simona Hankeova, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor \u010cervenka, Lenka Sarnov\u00e1, Elisabeth Verboven, &lt;strong>Tom\u00e1\u0161 Brabec&lt;\/strong>, Niklas K Bj\u00f6rkstr\u00f6m, Martin Gregor, &lt;strong>Jan Dobe\u0161&lt;\/strong> &amp; Emma R Andersson&lt;br>&lt;em>Published:&lt;\/em> 2024 &lt;em>in&lt;\/em> &lt;strong>EMBO MOLECULAR MEDICINE&lt;\/strong>&lt;br>DOI: &lt;a href=\\\"https:\/\/doi.org\/10.1038\/s44321-024-00145-8\\\">https:\/\/doi.org\/10.1038\/s44321-024-00145-8&lt;\/a>\"}},{\"@type\":\"Question\",\"name\":\"2023\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"&lt;strong>Segmented filamentous bacteria\u2013induced epithelial MHCII regulates cognate CD4&lt;sup>+&lt;\/sup> IELs and epithelial turnover&lt;\/strong>&lt;br>&lt;em>Authors:&lt;\/em> &lt;strong>Tom\u00e1\u0161 Brabec&lt;\/strong>, Martin Schwarzer, &lt;strong>Katar\u00edna Kov\u00e1\u010dov\u00e1&lt;\/strong>, &lt;strong>Martina Dobe\u0161ov\u00e1&lt;\/strong>, Dagmar Schierov\u00e1, Ji\u0159\u00ed B\u0159ezina, &lt;strong>Iva Pac\u00e1kov\u00e1&lt;\/strong>, Dagmar \u0160r\u016ftkov\u00e1, Osher Ben-Nun, Yael Goldfarb, Iva \u0160pl\u00edchalov\u00e1, Michal Kol\u00e1\u0159, Jakub Abramson, Dominik Filipp and &lt;strong>Jan Dobe\u0161&lt;\/strong>&lt;br>&lt;em>Published:&lt;\/em> 2023 &lt;em>in&lt;\/em> &lt;strong>Journal of Experimental Medicine&lt;\/strong>&lt;br>DOI: &lt;a href=\\\"https:\/\/doi.org\/10.1084\/jem.20230194\\\">10.1084\/jem.20230194&lt;\/a>&lt;br>&lt;br>&lt;strong>Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease&lt;\/strong>&lt;br>&lt;em>Authors:&lt;\/em> Yael Gruper, Anette S B Wolff, Liad Glanz, Frantisek Spoutil, Mihaela Cuida Marthinussen, Adriana Osickova, Yonatan Herzig, Yael Goldfarb, Goretti Aranaz-Novaliches, &lt;strong>Jan Dobe\u0161&lt;\/strong>, Noam Kadouri, Osher Ben-Nun, Amit Binyamin, Bar Lavi, Tal Givony, Razi Khalaila, Tom Gome, Tom\u00e1\u0161 Wald, Blanka Mrazkova, Carmel Sochen, Marine Besnard, Shifra Ben-Dor, Ester Feldmesser, Elisaveta M Orlova, Csaba Heged\u0171s, Istv\u00e1n Lamp\u00e9, Tam\u00e1s Papp, Szabolcs Felszeghy, Radislav Sedlacek, Esti Davidovich, Noa Tal, Dror S Shouval, Raanan Shamir, Carole Guillonneau, Zsuzsa Szondy, Knut E A Lundin, Radim Osicka, Jan Prochazka, Eystein S Husebye, Jakub Abramson&lt;br>&lt;em>Published:&lt;\/em> 2023 &lt;em>in&lt;\/em> &lt;strong>Nature&lt;\/strong>&lt;br>DOI: &lt;a href=\\\"https:\/\/doi.org\/10.1038\/s41586-023-06776-0\\\">10.1038\/s41586-023-06776-0&lt;\/a>&lt;br>&lt;br>&lt;strong>Thymic mimetic cells function beyond self-tolerance&lt;\/strong>&lt;br>&lt;em>Authors:&lt;\/em> Tal Givony, Dena Leshkowitz, Diana Del Castillo, Shir Nevo, Noam Kadouri, Bareket Dassa, Yael Gruper, Razi Khalaila, Osher Ben-Nun, Tom Gome, &lt;strong>Jan Dobe\u0161&lt;\/strong>, Shifra Ben-Dor, Merav Kedmi, Hadas Keren-Shaul, Rebecca Heffner-Krausz, Ziv Porat, Ofra Golani, Yoseph Addadi, Ori Brenner, David D. Lo, Yael Goldfarb, Jakub Abramson&lt;br>&lt;em>Published:&lt;\/em> 2023 &lt;em>in&lt;\/em> &lt;strong>Nature&lt;\/strong>&lt;br>DOI: &lt;a href=\\\"https:\/\/doi.org\/10.1038\/s41586-023-06512-8\\\">10.1038\/s41586-023-06512-8&lt;\/a>&lt;br>&lt;br>&lt;strong>The emerging family of ROR\u03b3t&lt;sup>+&lt;\/sup> antigen-presenting cells&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Jakub Abramson*, &lt;strong>Jan Dobe\u0161&lt;\/strong>*, Mengze Lyu*, Gregory F. Sonnenberg*&lt;br>&lt;em>Published:\u00a0&lt;\/em>2023&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Nature Reviews Immunology&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a href=\\\"https:\/\/doi.org\/10.1038\/s41577-023-00906-5\\\">10.1038\/s41577-023-00906-5005&lt;\/a>&lt;br>*all authors contributed equally&lt;br>&lt;br>&lt;strong>IL-17 driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>&lt;strong>Tomas Brabec&lt;\/strong>, Matou\u0161 Vobo\u0159il, Dagmar Schierova, Evgeny Valter, Iva Splichalova, &lt;strong>Jan Dobe\u0161&lt;\/strong>, Jiri Brezina, Martina Dobesova, Aigerim Aidarova, Martin Jakubec, Jasper Manning, Richard Blumberg, Ari Waissman, Michal Kolar, Jan Kubovciak, Dagmar Srutkova, Tomas Hudcovic, Martin Schwarzer, Eva Fronkova, Tereza Pinkasova, Petr Jabandziev, Dominik Filipp&lt;br>&lt;em>Published:\u00a0&lt;\/em>2023&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Mucosal Immunology&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a href=\\\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1933021923000053?via%3Dihub\\\">10.1016\/j.mucimm.2023.01.005&lt;\/a>\"}},{\"@type\":\"Question\",\"name\":\"2022\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"&lt;strong>Extrathymic expression of Aire controls the induction of effective T&lt;sub>H&lt;\/sub>17 cell-mediated immune response to &lt;em>Candida albicans&lt;\/em>&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>&lt;strong>Jan Dobe\u0161&lt;\/strong>, Osher Ben-Nun, Amit Binyamin, Liat Stoler-Barak, Bergithe E. Oftedal, Yael Goldfarb, Noam Kadouri, Yael Gruper, Tal Givony, Itay Zalayat, &lt;strong>Katar\u00edna Kov\u00e1\u010dov\u00e1&lt;\/strong>, &lt;strong>Helena B\u00f6hmov\u00e1&lt;\/strong>, &lt;strong>Evgeny Valter&lt;\/strong>, Ziv Shulman, Dominik Filipp, Eystein S. Husebye, Jakub Abramson&lt;br>&lt;em>Published:\u00a0&lt;\/em>2022&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Nature Immunology&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a href=\\\"https:\/\/www.nature.com\/articles\/s41590-022-01247-6\\\">10.1038\/s41590-022-01247-6&lt;\/a>&lt;br>&lt;br>&lt;strong>Transcriptional regulation of the thymus master regulator &lt;em>Foxn1&lt;\/em>&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben Dor, Golda Damari, Bareket Dassa, &lt;strong>Jan Dobes&lt;\/strong>, Dieter Weichenhan, Marion B\u00e4hr, Michelle Paulsen, Rebecca Haffner-Krausz, Marcus A Mall, Christoph Plass, Yael Goldfarb, Jakub Abramson&lt;br>&lt;em>Published:\u00a0&lt;\/em>2022&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Science Immunology&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/doi.org\/10.1126\/sciimmunol.abn8144\\\" target=\\\"_blank\\\">10.1126\/sciimmunol.abn8144&lt;\/a>&lt;br>&lt;br>&lt;strong>A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Matou\u0161 Vobo\u0159il, Ji\u0159\u00ed B\u0159ezina, Tom\u00e1\u0161 Brabec, &lt;strong>Jan Dobe\u0161&lt;\/strong>, Ond\u0159ej Ballek, Martina Dobe\u0161ov\u00e1, Jasper Manning, Richard S Blumberg, Dominik Filipp&lt;br>&lt;em>Published:\u00a0&lt;\/em>2022&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Elife&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/elifesciences.org\/articles\/71578\\\" target=\\\"_blank\\\">10.7554\/eLife.71578&lt;\/a>\"}},{\"@type\":\"Question\",\"name\":\"2021\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"&lt;strong>Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Yael Goldfarb, Tal Givony, Noam Kadouri, &lt;strong>Jan Dobe\u0161&lt;\/strong>, Cristina Peligero-Cruz, Itay Zalayat, Golda Damari, Bareket Dassa, Shifra Ben-Dor, Yael Gruper, Bergithe E Oftedal, Eirik Bratland, Martina M Erichsen, Amund Berger, Ayelet Avin, Shir Nevo, Uku Haljasorg, Yael Kuperman, Adi Ulman, Rebecca Haffner-Krausz, Ziv Porat, Ulus Atasoy, Dena Leshkowitz, Eystein S Husebye, Jakub Abramson&lt;br>&lt;em>Published:\u00a0&lt;\/em>2021&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Journal of Experimental Medicine&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/rupress.org\/jem\/article\/218\/11\/e20201076\/212621\/Mechanistic-dissection-of-dominant-AIRE-mutations\\\" target=\\\"_blank\\\">10.1084\/jem.20201076&lt;\/a>\"}},{\"@type\":\"Question\",\"name\":\"2020\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"&lt;strong>IL18 signaling promotes homing of mature Tregs into the thymus&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Cristina Peligero-Cruz, Tal Givony, Arnau Seb\u00e9-Pedr\u00f3s, &lt;strong>Jan Dobe\u0161&lt;\/strong>, Noam Kadouri, Shir Nevo, Francesco Roncato, Ronen Alon, Yael Goldfarb, Jakub Abramson&lt;br>&lt;em>Published:\u00a0&lt;\/em>2020&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Elife&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/elifesciences.org\/articles\/58213\\\" target=\\\"_blank\\\">10.7554\/eLife.58213&lt;\/a>&lt;br>&lt;br>&lt;strong>Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Matou\u0161 Vobo\u0159il, Tom\u00e1\u0161 Brabec, &lt;strong>Jan Dobe\u0161&lt;\/strong>, Iva \u0160pl\u00edchalov\u00e1, Ji\u0159\u00ed B\u0159ezina, Ad\u00e9la \u010cepkov\u00e1, Martina Dobe\u0161ov\u00e1, Aigerim Aidarova, Jan Kubov\u010diak, Oksana Tsyklauri, Ond\u0159ej \u0160t\u011bp\u00e1nek, Vladim\u00edr Bene\u0161, Radislav Sedl\u00e1\u010dek, Ludger Klein, Michal Kol\u00e1\u0159, Dominik Filipp&lt;br>&lt;em>Published:\u00a0&lt;\/em>2020&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Nature Communications&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/www.nature.com\/articles\/s41467-020-16081-3\\\" target=\\\"_blank\\\">10.1038\/s41467-020-16081-3&lt;\/a>\"}},{\"@type\":\"Question\",\"name\":\"2019\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"&lt;strong>Aire-expressing ILC3-like cells in the lymph node display potent APC features&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Tomoyoshi Yamano, Jan Dobe\u0161, Matou\u0161 Vobo\u0159il, Madlen Steinert, Tom\u00e1\u0161 Brabec, Natalia Zi\u0119tara, Martina Dobe\u0161ov\u00e1, Caspar Ohnmacht, Martti Laan, Part Peterson, Vladimir Benes, Radislav Sedl\u00e1\u010dek, Rikinari Hanayama, Michal Kol\u00e1\u0159, Ludger Klein, Dominik Filipp&lt;br>&lt;em>Published:\u00a0&lt;\/em>2019&lt;em>\u00a0in\u00a0&lt;\/em>Journal of Experimental Medicine&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/rupress.org\/jem\/article\/216\/5\/1027\/121004\/Aire-expressing-ILC3-like-cells-in-the-lymph-node\\\" target=\\\"_blank\\\"> 10.1084\/jem.20181430&lt;\/a>&lt;br>&lt;br>&lt;strong>Enteric \u03b1-defensins on the verge of intestinal immune tolerance and inflammation&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Dominik Filipp, Tom\u00e1\u0161 Brabec, Matou\u0161 Vobo\u0159il, &lt;strong>Jan Dobe\u0161&lt;\/strong>&lt;br>&lt;em>Published:\u00a0&lt;\/em>2019&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Seminars in Cell &amp; Developmental Biology&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S108495211730407X?via%3Dihub\\\" target=\\\"_blank\\\">10.1016\/j.semcdb.2018.01.007&lt;\/a>\"}},{\"@type\":\"Question\",\"name\":\"2018-2012\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"&lt;strong>A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>&lt;strong>Jan Dobe\u0161&lt;\/strong>, Frank Edenhofer, Matou\u0161 Vobo\u0159il, Tom\u00e1\u0161 Brabec, Martina Dobe\u0161ov\u00e1, Ad\u00e9la \u010cepkov\u00e1, Ludger Klein, Klaus Rajewsky, Dominik Filipp&lt;br>&lt;em>Published:\u00a0&lt;\/em>2018&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>European Journal of Immunology&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201747267\\\" target=\\\"_blank\\\">10.1002\/eji.201747267&lt;\/a>&lt;br>&lt;br>&lt;strong>Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Vitezslav Kriz, Michaela Krausova, Petra Buresova, &lt;strong>Jan Dobes&lt;\/strong>, Dusan Hrckulak, Olga Babosova, Jiri Svec, Vladimir Korinek&lt;br>&lt;em>Published:\u00a0&lt;\/em>2017&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Transgenic Research&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/link.springer.com\/article\/10.1007\/s11248-017-0027-0\\\" target=\\\"_blank\\\">10.1007\/s11248-017-0027-0&lt;\/a>&lt;br>&lt;br>&lt;strong>Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric \u03b1-Defensins&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>&lt;strong>Jan Dobe\u0161&lt;\/strong>, Ale\u0161 Neuwirth, Martina Dobe\u0161ov\u00e1, Matou\u0161 Vobo\u0159il, Jana Balounov\u00e1, Ond\u0159ej Ballek, Jan Lebl, Antonella Meloni, Kai Krohn, Nicolas Kluger, Annamari Ranki, Dominik Filipp&lt;br>&lt;em>Published:\u00a0&lt;\/em>2015&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Gastroenterology&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/www.gastrojournal.org\/article\/S0016-5085(15)00681-2\/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F\\\" target=\\\"_blank\\\"> 10.1053\/j.gastro.2015.05.009&lt;\/a>&lt;br>&lt;br>&lt;strong>HIC1 Tumor Suppressor Loss Potentiates TLR2\/NF-\u03baB Signaling and Promotes Tissue Damage-Associated Tumorigenesis&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Lucie Janeckova, Vendula Pospichalova, Bohumil Fafilek, Martina Vojtechova, Jolana Tureckova, &lt;strong>Jan Dobes&lt;\/strong>, Marion Dubuissez, Dominique Leprince, Nikol Baloghova, Monika Horazna, Adela Hlavata, Jitka Stancikova, Eva Sloncova, Katerina Galuskova, Hynek Strnad, Vladimir Korinek&lt;br>&lt;em>Published:\u00a0&lt;\/em>2015&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Molecular Cancer Research&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/aacrjournals.org\/mcr\/article\/13\/7\/1139\/89598\/HIC1-Tumor-Suppressor-Loss-Potentiates-TLR2-NF-B\\\" target=\\\"_blank\\\">10.1158\/1541-7786.MCR-15-0033&lt;\/a>&lt;br>&lt;strong>&lt;br>NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Jitka Stancikova, Michaela Krausova, Michal Kolar, Bohumil Fafilek, Jiri Svec, Radislav Sedlacek, Magdalena Neroldova, &lt;strong>Jan Dobes&lt;\/strong>, Monika Horazna, Lucie Janeckova, Martina Vojtechova, Martin Oliverius, Milan Jirsa, Vladimir Korinek&lt;br>&lt;em>Published:\u00a0&lt;\/em>2015&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Cellular Signalling&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0898656814003544?via%3Dihub\\\" target=\\\"_blank\\\">10.1016\/j.cellsig.2014.11.008&lt;\/a>&lt;br>&lt;br>&lt;strong>Eosinophils from patients with type 1 diabetes mellitus express high level of myeloid alpha-defensins and myeloperoxidase&lt;\/strong>&lt;br>&lt;em>Authors:\u00a0&lt;\/em>Ale\u0161 Neuwirth, &lt;strong>Jan Dobe\u0161&lt;\/strong>, Jana Oujezdsk\u00e1, Ond\u0159ej Ballek, Martina Bene\u0161ov\u00e1, Zden\u011bk Sumn\u00edk, Jana V\u010del\u00e1kov\u00e1, Stanislava Kolou\u0161kov\u00e1, Barbora Obermannov\u00e1, Michal Kol\u00e1\u0159, Kate\u0159ina Stechov\u00e1, Dominik Filipp&lt;br>&lt;em>Published:\u00a0&lt;\/em>2012&lt;em>\u00a0in\u00a0&lt;\/em>&lt;strong>Cellular Immunology&lt;\/strong>&lt;br>&lt;em>DOI:\u00a0&lt;\/em>&lt;a rel=\\\"noreferrer noopener\\\" href=\\\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0008874911003054?via%3Dihub\\\" target=\\\"_blank\\\">10.1016\/j.cellimm.2011.12.001&lt;\/a>\"}}]}<\/script>\n<div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-9ce45bd5\" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\"><span class=\"uagb-icon uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M192 384c-8.188 0-16.38-3.125-22.62-9.375l-160-160c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L192 306.8l137.4-137.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-160 160C208.4 380.9 200.2 384 192 384z\"><\/path><\/svg><\/span><span class=\"uagb-icon-active uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M352 352c-8.188 0-16.38-3.125-22.62-9.375L192 205.3l-137.4 137.4c-12.5 12.5-32.75 12.5-45.25 0s-12.5-32.75 0-45.25l160-160c12.5-12.5 32.75-12.5 45.25 0l160 160c12.5 12.5 12.5 32.75 0 45.25C368.4 348.9 360.2 352 352 352z\"><\/path><\/svg><\/span><h4 class=\"uagb-question\">2025<\/h4><\/div><div class=\"uagb-faq-content\"><p><strong>Dietary influence and immune balance: Regulating CD4+ IEL responses and MHCII in the gut<\/strong><br><em>Authors:<\/em> <strong>Jan Dobe\u0161<\/strong>, <strong>Tom\u00e1\u0161 Brabec<\/strong><br><em>Published:<\/em> 2025 <em>in<\/em> <strong>Mucosal Immunology<\/strong><br>DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2024.12.011\">https:\/\/doi.org\/10.1016\/j.mucimm.2024.12.011<\/a><br><br><strong>CUL4A exhibits tumor-suppressing role via regulation of HUWE1-mediated SMAD3 intracellular shuttling<\/strong><br><em>Authors:<\/em> Veronika Danek, Jolana Tureckova, Kerstin Huebner, Katharina Erlenbach-Wuensch, Petra Baranova, <strong>Jan Dobes<\/strong>, Jana Balounova, Michaela Simova, Vendula Novosadova, Carlos Eduardo Madureira Trufen, Michaela Prochazkova, Pavel Talacko, Karel Harant, Cyril Barinka, Inken M Beck, Regine Schneider-Stock, Radislav Sedlacek, Jan Prochazka<br><em>Published:<\/em> 2025 <em>in<\/em> <strong>Cancer Letters<\/strong><br>DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.canlet.2025.217663\">https:\/\/doi.org\/10.1016\/j.canlet.2025.217663 <\/a><\/p><\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-8cc93fef\" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\"><span class=\"uagb-icon uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M192 384c-8.188 0-16.38-3.125-22.62-9.375l-160-160c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L192 306.8l137.4-137.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-160 160C208.4 380.9 200.2 384 192 384z\"><\/path><\/svg><\/span><span class=\"uagb-icon-active uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M352 352c-8.188 0-16.38-3.125-22.62-9.375L192 205.3l-137.4 137.4c-12.5 12.5-32.75 12.5-45.25 0s-12.5-32.75 0-45.25l160-160c12.5-12.5 32.75-12.5 45.25 0l160 160c12.5 12.5 12.5 32.75 0 45.25C368.4 348.9 360.2 352 352 352z\"><\/path><\/svg><\/span><h4 class=\"uagb-question\">2024<\/h4><\/div><div class=\"uagb-faq-content\"><p><strong>Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects<\/strong><br><em>Authors:<\/em> Jan Ma\u0161ek, Iva Filipovic, No\u00e9mi Van Hul, Lenka Belicov\u00e1, Mark\u00e9ta Jirou\u0161kov\u00e1, Daniel V Oliveira, Anna Maria Frontino, Simona Hankeova, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor \u010cervenka, Lenka Sarnov\u00e1, Elisabeth Verboven, <strong>Tom\u00e1\u0161 Brabec<\/strong>, Niklas K Bj\u00f6rkstr\u00f6m, Martin Gregor, <strong>Jan Dobe\u0161<\/strong> &amp; Emma R Andersson<br><em>Published:<\/em> 2024 <em>in<\/em> <strong>EMBO MOLECULAR MEDICINE<\/strong><br>DOI: <a href=\"https:\/\/doi.org\/10.1038\/s44321-024-00145-8\">https:\/\/doi.org\/10.1038\/s44321-024-00145-8<\/a><\/p><\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-9b8663a7\" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\"><span class=\"uagb-icon uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M192 384c-8.188 0-16.38-3.125-22.62-9.375l-160-160c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L192 306.8l137.4-137.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-160 160C208.4 380.9 200.2 384 192 384z\"><\/path><\/svg><\/span><span class=\"uagb-icon-active uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M352 352c-8.188 0-16.38-3.125-22.62-9.375L192 205.3l-137.4 137.4c-12.5 12.5-32.75 12.5-45.25 0s-12.5-32.75 0-45.25l160-160c12.5-12.5 32.75-12.5 45.25 0l160 160c12.5 12.5 12.5 32.75 0 45.25C368.4 348.9 360.2 352 352 352z\"><\/path><\/svg><\/span><h4 class=\"uagb-question\">2023<\/h4><\/div><div class=\"uagb-faq-content\"><p><strong>Segmented filamentous bacteria\u2013induced epithelial MHCII regulates cognate CD4<sup>+<\/sup> IELs and epithelial turnover<\/strong><br><em>Authors:<\/em> <strong>Tom\u00e1\u0161 Brabec<\/strong>, Martin Schwarzer, <strong>Katar\u00edna Kov\u00e1\u010dov\u00e1<\/strong>, <strong>Martina Dobe\u0161ov\u00e1<\/strong>, Dagmar Schierov\u00e1, Ji\u0159\u00ed B\u0159ezina, <strong>Iva Pac\u00e1kov\u00e1<\/strong>, Dagmar \u0160r\u016ftkov\u00e1, Osher Ben-Nun, Yael Goldfarb, Iva \u0160pl\u00edchalov\u00e1, Michal Kol\u00e1\u0159, Jakub Abramson, Dominik Filipp and <strong>Jan Dobe\u0161<\/strong><br><em>Published:<\/em> 2023 <em>in<\/em> <strong>Journal of Experimental Medicine<\/strong><br>DOI: <a href=\"https:\/\/doi.org\/10.1084\/jem.20230194\">10.1084\/jem.20230194<\/a><br><br><strong>Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease<\/strong><br><em>Authors:<\/em> Yael Gruper, Anette S B Wolff, Liad Glanz, Frantisek Spoutil, Mihaela Cuida Marthinussen, Adriana Osickova, Yonatan Herzig, Yael Goldfarb, Goretti Aranaz-Novaliches, <strong>Jan Dobe\u0161<\/strong>, Noam Kadouri, Osher Ben-Nun, Amit Binyamin, Bar Lavi, Tal Givony, Razi Khalaila, Tom Gome, Tom\u00e1\u0161 Wald, Blanka Mrazkova, Carmel Sochen, Marine Besnard, Shifra Ben-Dor, Ester Feldmesser, Elisaveta M Orlova, Csaba Heged\u0171s, Istv\u00e1n Lamp\u00e9, Tam\u00e1s Papp, Szabolcs Felszeghy, Radislav Sedlacek, Esti Davidovich, Noa Tal, Dror S Shouval, Raanan Shamir, Carole Guillonneau, Zsuzsa Szondy, Knut E A Lundin, Radim Osicka, Jan Prochazka, Eystein S Husebye, Jakub Abramson<br><em>Published:<\/em> 2023 <em>in<\/em> <strong>Nature<\/strong><br>DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41586-023-06776-0\">10.1038\/s41586-023-06776-0<\/a><br><br><strong>Thymic mimetic cells function beyond self-tolerance<\/strong><br><em>Authors:<\/em> Tal Givony, Dena Leshkowitz, Diana Del Castillo, Shir Nevo, Noam Kadouri, Bareket Dassa, Yael Gruper, Razi Khalaila, Osher Ben-Nun, Tom Gome, <strong>Jan Dobe\u0161<\/strong>, Shifra Ben-Dor, Merav Kedmi, Hadas Keren-Shaul, Rebecca Heffner-Krausz, Ziv Porat, Ofra Golani, Yoseph Addadi, Ori Brenner, David D. Lo, Yael Goldfarb, Jakub Abramson<br><em>Published:<\/em> 2023 <em>in<\/em> <strong>Nature<\/strong><br>DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41586-023-06512-8\">10.1038\/s41586-023-06512-8<\/a><br><br><strong>The emerging family of ROR\u03b3t<sup>+<\/sup> antigen-presenting cells<\/strong><br><em>Authors:\u00a0<\/em>Jakub Abramson*, <strong>Jan Dobe\u0161<\/strong>*, Mengze Lyu*, Gregory F. Sonnenberg*<br><em>Published:\u00a0<\/em>2023<em>\u00a0in\u00a0<\/em><strong>Nature Reviews Immunology<\/strong><br><em>DOI:\u00a0<\/em><a href=\"https:\/\/doi.org\/10.1038\/s41577-023-00906-5\">10.1038\/s41577-023-00906-5005<\/a><br>*all authors contributed equally<br><br><strong>IL-17 driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum<\/strong><br><em>Authors:\u00a0<\/em><strong>Tomas Brabec<\/strong>, Matou\u0161 Vobo\u0159il, Dagmar Schierova, Evgeny Valter, Iva Splichalova, <strong>Jan Dobe\u0161<\/strong>, Jiri Brezina, Martina Dobesova, Aigerim Aidarova, Martin Jakubec, Jasper Manning, Richard Blumberg, Ari Waissman, Michal Kolar, Jan Kubovciak, Dagmar Srutkova, Tomas Hudcovic, Martin Schwarzer, Eva Fronkova, Tereza Pinkasova, Petr Jabandziev, Dominik Filipp<br><em>Published:\u00a0<\/em>2023<em>\u00a0in\u00a0<\/em><strong>Mucosal Immunology<\/strong><br><em>DOI:\u00a0<\/em><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1933021923000053?via%3Dihub\">10.1016\/j.mucimm.2023.01.005<\/a><\/p><\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-71b11ecd\" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\"><span class=\"uagb-icon uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M192 384c-8.188 0-16.38-3.125-22.62-9.375l-160-160c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L192 306.8l137.4-137.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-160 160C208.4 380.9 200.2 384 192 384z\"><\/path><\/svg><\/span><span class=\"uagb-icon-active uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M352 352c-8.188 0-16.38-3.125-22.62-9.375L192 205.3l-137.4 137.4c-12.5 12.5-32.75 12.5-45.25 0s-12.5-32.75 0-45.25l160-160c12.5-12.5 32.75-12.5 45.25 0l160 160c12.5 12.5 12.5 32.75 0 45.25C368.4 348.9 360.2 352 352 352z\"><\/path><\/svg><\/span><h4 class=\"uagb-question\">2022<\/h4><\/div><div class=\"uagb-faq-content\"><p><strong>Extrathymic expression of Aire controls the induction of effective T<sub>H<\/sub>17 cell-mediated immune response to <em>Candida albicans<\/em><\/strong><br><em>Authors:\u00a0<\/em><strong>Jan Dobe\u0161<\/strong>, Osher Ben-Nun, Amit Binyamin, Liat Stoler-Barak, Bergithe E. Oftedal, Yael Goldfarb, Noam Kadouri, Yael Gruper, Tal Givony, Itay Zalayat, <strong>Katar\u00edna Kov\u00e1\u010dov\u00e1<\/strong>, <strong>Helena B\u00f6hmov\u00e1<\/strong>, <strong>Evgeny Valter<\/strong>, Ziv Shulman, Dominik Filipp, Eystein S. Husebye, Jakub Abramson<br><em>Published:\u00a0<\/em>2022<em>\u00a0in\u00a0<\/em><strong>Nature Immunology<\/strong><br><em>DOI:\u00a0<\/em><a href=\"https:\/\/www.nature.com\/articles\/s41590-022-01247-6\">10.1038\/s41590-022-01247-6<\/a><br><br><strong>Transcriptional regulation of the thymus master regulator <em>Foxn1<\/em><\/strong><br><em>Authors:\u00a0<\/em>Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben Dor, Golda Damari, Bareket Dassa, <strong>Jan Dobes<\/strong>, Dieter Weichenhan, Marion B\u00e4hr, Michelle Paulsen, Rebecca Haffner-Krausz, Marcus A Mall, Christoph Plass, Yael Goldfarb, Jakub Abramson<br><em>Published:\u00a0<\/em>2022<em>\u00a0in\u00a0<\/em><strong>Science Immunology<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1126\/sciimmunol.abn8144\" target=\"_blank\">10.1126\/sciimmunol.abn8144<\/a><br><br><strong>A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer<\/strong><br><em>Authors:\u00a0<\/em>Matou\u0161 Vobo\u0159il, Ji\u0159\u00ed B\u0159ezina, Tom\u00e1\u0161 Brabec, <strong>Jan Dobe\u0161<\/strong>, Ond\u0159ej Ballek, Martina Dobe\u0161ov\u00e1, Jasper Manning, Richard S Blumberg, Dominik Filipp<br><em>Published:\u00a0<\/em>2022<em>\u00a0in\u00a0<\/em><strong>Elife<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/elifesciences.org\/articles\/71578\" target=\"_blank\">10.7554\/eLife.71578<\/a><\/p><\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-aa006f37\" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\"><span class=\"uagb-icon uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M192 384c-8.188 0-16.38-3.125-22.62-9.375l-160-160c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L192 306.8l137.4-137.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-160 160C208.4 380.9 200.2 384 192 384z\"><\/path><\/svg><\/span><span class=\"uagb-icon-active uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M352 352c-8.188 0-16.38-3.125-22.62-9.375L192 205.3l-137.4 137.4c-12.5 12.5-32.75 12.5-45.25 0s-12.5-32.75 0-45.25l160-160c12.5-12.5 32.75-12.5 45.25 0l160 160c12.5 12.5 12.5 32.75 0 45.25C368.4 348.9 360.2 352 352 352z\"><\/path><\/svg><\/span><h4 class=\"uagb-question\">2021<\/h4><\/div><div class=\"uagb-faq-content\"><p><strong>Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation<\/strong><br><em>Authors:\u00a0<\/em>Yael Goldfarb, Tal Givony, Noam Kadouri, <strong>Jan Dobe\u0161<\/strong>, Cristina Peligero-Cruz, Itay Zalayat, Golda Damari, Bareket Dassa, Shifra Ben-Dor, Yael Gruper, Bergithe E Oftedal, Eirik Bratland, Martina M Erichsen, Amund Berger, Ayelet Avin, Shir Nevo, Uku Haljasorg, Yael Kuperman, Adi Ulman, Rebecca Haffner-Krausz, Ziv Porat, Ulus Atasoy, Dena Leshkowitz, Eystein S Husebye, Jakub Abramson<br><em>Published:\u00a0<\/em>2021<em>\u00a0in\u00a0<\/em><strong>Journal of Experimental Medicine<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/rupress.org\/jem\/article\/218\/11\/e20201076\/212621\/Mechanistic-dissection-of-dominant-AIRE-mutations\" target=\"_blank\">10.1084\/jem.20201076<\/a><\/p><\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-b0ec2427\" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\"><span class=\"uagb-icon uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M192 384c-8.188 0-16.38-3.125-22.62-9.375l-160-160c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L192 306.8l137.4-137.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-160 160C208.4 380.9 200.2 384 192 384z\"><\/path><\/svg><\/span><span class=\"uagb-icon-active uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M352 352c-8.188 0-16.38-3.125-22.62-9.375L192 205.3l-137.4 137.4c-12.5 12.5-32.75 12.5-45.25 0s-12.5-32.75 0-45.25l160-160c12.5-12.5 32.75-12.5 45.25 0l160 160c12.5 12.5 12.5 32.75 0 45.25C368.4 348.9 360.2 352 352 352z\"><\/path><\/svg><\/span><h4 class=\"uagb-question\">2020<\/h4><\/div><div class=\"uagb-faq-content\"><p><strong>IL18 signaling promotes homing of mature Tregs into the thymus<\/strong><br><em>Authors:\u00a0<\/em>Cristina Peligero-Cruz, Tal Givony, Arnau Seb\u00e9-Pedr\u00f3s, <strong>Jan Dobe\u0161<\/strong>, Noam Kadouri, Shir Nevo, Francesco Roncato, Ronen Alon, Yael Goldfarb, Jakub Abramson<br><em>Published:\u00a0<\/em>2020<em>\u00a0in\u00a0<\/em><strong>Elife<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/elifesciences.org\/articles\/58213\" target=\"_blank\">10.7554\/eLife.58213<\/a><br><br><strong>Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation<\/strong><br><em>Authors:\u00a0<\/em>Matou\u0161 Vobo\u0159il, Tom\u00e1\u0161 Brabec, <strong>Jan Dobe\u0161<\/strong>, Iva \u0160pl\u00edchalov\u00e1, Ji\u0159\u00ed B\u0159ezina, Ad\u00e9la \u010cepkov\u00e1, Martina Dobe\u0161ov\u00e1, Aigerim Aidarova, Jan Kubov\u010diak, Oksana Tsyklauri, Ond\u0159ej \u0160t\u011bp\u00e1nek, Vladim\u00edr Bene\u0161, Radislav Sedl\u00e1\u010dek, Ludger Klein, Michal Kol\u00e1\u0159, Dominik Filipp<br><em>Published:\u00a0<\/em>2020<em>\u00a0in\u00a0<\/em><strong>Nature Communications<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/www.nature.com\/articles\/s41467-020-16081-3\" target=\"_blank\">10.1038\/s41467-020-16081-3<\/a><\/p><\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-ddb93fa0\" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\"><span class=\"uagb-icon uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M192 384c-8.188 0-16.38-3.125-22.62-9.375l-160-160c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L192 306.8l137.4-137.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-160 160C208.4 380.9 200.2 384 192 384z\"><\/path><\/svg><\/span><span class=\"uagb-icon-active uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M352 352c-8.188 0-16.38-3.125-22.62-9.375L192 205.3l-137.4 137.4c-12.5 12.5-32.75 12.5-45.25 0s-12.5-32.75 0-45.25l160-160c12.5-12.5 32.75-12.5 45.25 0l160 160c12.5 12.5 12.5 32.75 0 45.25C368.4 348.9 360.2 352 352 352z\"><\/path><\/svg><\/span><h4 class=\"uagb-question\">2019<\/h4><\/div><div class=\"uagb-faq-content\"><p><strong>Aire-expressing ILC3-like cells in the lymph node display potent APC features<\/strong><br><em>Authors:\u00a0<\/em>Tomoyoshi Yamano, Jan Dobe\u0161, Matou\u0161 Vobo\u0159il, Madlen Steinert, Tom\u00e1\u0161 Brabec, Natalia Zi\u0119tara, Martina Dobe\u0161ov\u00e1, Caspar Ohnmacht, Martti Laan, Part Peterson, Vladimir Benes, Radislav Sedl\u00e1\u010dek, Rikinari Hanayama, Michal Kol\u00e1\u0159, Ludger Klein, Dominik Filipp<br><em>Published:\u00a0<\/em>2019<em>\u00a0in\u00a0<\/em>Journal of Experimental Medicine<br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/rupress.org\/jem\/article\/216\/5\/1027\/121004\/Aire-expressing-ILC3-like-cells-in-the-lymph-node\" target=\"_blank\"> 10.1084\/jem.20181430<\/a><br><br><strong>Enteric \u03b1-defensins on the verge of intestinal immune tolerance and inflammation<\/strong><br><em>Authors:\u00a0<\/em>Dominik Filipp, Tom\u00e1\u0161 Brabec, Matou\u0161 Vobo\u0159il, <strong>Jan Dobe\u0161<\/strong><br><em>Published:\u00a0<\/em>2019<em>\u00a0in\u00a0<\/em><strong>Seminars in Cell &amp; Developmental Biology<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S108495211730407X?via%3Dihub\" target=\"_blank\">10.1016\/j.semcdb.2018.01.007<\/a><\/p><\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-faq-child uagb-faq-child__outer-wrap uagb-faq-item uagb-block-8e10e4f6\" role=\"tab\" tabindex=\"0\"><div class=\"uagb-faq-questions-button uagb-faq-questions\"><span class=\"uagb-icon uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M192 384c-8.188 0-16.38-3.125-22.62-9.375l-160-160c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L192 306.8l137.4-137.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-160 160C208.4 380.9 200.2 384 192 384z\"><\/path><\/svg><\/span><span class=\"uagb-icon-active uagb-faq-icon-wrap\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M352 352c-8.188 0-16.38-3.125-22.62-9.375L192 205.3l-137.4 137.4c-12.5 12.5-32.75 12.5-45.25 0s-12.5-32.75 0-45.25l160-160c12.5-12.5 32.75-12.5 45.25 0l160 160c12.5 12.5 12.5 32.75 0 45.25C368.4 348.9 360.2 352 352 352z\"><\/path><\/svg><\/span><h4 class=\"uagb-question\">2018-2012<\/h4><\/div><div class=\"uagb-faq-content\"><p><strong>A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire<\/strong><br><em>Authors:\u00a0<\/em><strong>Jan Dobe\u0161<\/strong>, Frank Edenhofer, Matou\u0161 Vobo\u0159il, Tom\u00e1\u0161 Brabec, Martina Dobe\u0161ov\u00e1, Ad\u00e9la \u010cepkov\u00e1, Ludger Klein, Klaus Rajewsky, Dominik Filipp<br><em>Published:\u00a0<\/em>2018<em>\u00a0in\u00a0<\/em><strong>European Journal of Immunology<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201747267\" target=\"_blank\">10.1002\/eji.201747267<\/a><br><br><strong>Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse<\/strong><br><em>Authors:\u00a0<\/em>Vitezslav Kriz, Michaela Krausova, Petra Buresova, <strong>Jan Dobes<\/strong>, Dusan Hrckulak, Olga Babosova, Jiri Svec, Vladimir Korinek<br><em>Published:\u00a0<\/em>2017<em>\u00a0in\u00a0<\/em><strong>Transgenic Research<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/link.springer.com\/article\/10.1007\/s11248-017-0027-0\" target=\"_blank\">10.1007\/s11248-017-0027-0<\/a><br><br><strong>Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric \u03b1-Defensins<\/strong><br><em>Authors:\u00a0<\/em><strong>Jan Dobe\u0161<\/strong>, Ale\u0161 Neuwirth, Martina Dobe\u0161ov\u00e1, Matou\u0161 Vobo\u0159il, Jana Balounov\u00e1, Ond\u0159ej Ballek, Jan Lebl, Antonella Meloni, Kai Krohn, Nicolas Kluger, Annamari Ranki, Dominik Filipp<br><em>Published:\u00a0<\/em>2015<em>\u00a0in\u00a0<\/em><strong>Gastroenterology<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/www.gastrojournal.org\/article\/S0016-5085(15)00681-2\/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F\" target=\"_blank\"> 10.1053\/j.gastro.2015.05.009<\/a><br><br><strong>HIC1 Tumor Suppressor Loss Potentiates TLR2\/NF-\u03baB Signaling and Promotes Tissue Damage-Associated Tumorigenesis<\/strong><br><em>Authors:\u00a0<\/em>Lucie Janeckova, Vendula Pospichalova, Bohumil Fafilek, Martina Vojtechova, Jolana Tureckova, <strong>Jan Dobes<\/strong>, Marion Dubuissez, Dominique Leprince, Nikol Baloghova, Monika Horazna, Adela Hlavata, Jitka Stancikova, Eva Sloncova, Katerina Galuskova, Hynek Strnad, Vladimir Korinek<br><em>Published:\u00a0<\/em>2015<em>\u00a0in\u00a0<\/em><strong>Molecular Cancer Research<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/aacrjournals.org\/mcr\/article\/13\/7\/1139\/89598\/HIC1-Tumor-Suppressor-Loss-Potentiates-TLR2-NF-B\" target=\"_blank\">10.1158\/1541-7786.MCR-15-0033<\/a><br><strong><br>NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling<\/strong><br><em>Authors:\u00a0<\/em>Jitka Stancikova, Michaela Krausova, Michal Kolar, Bohumil Fafilek, Jiri Svec, Radislav Sedlacek, Magdalena Neroldova, <strong>Jan Dobes<\/strong>, Monika Horazna, Lucie Janeckova, Martina Vojtechova, Martin Oliverius, Milan Jirsa, Vladimir Korinek<br><em>Published:\u00a0<\/em>2015<em>\u00a0in\u00a0<\/em><strong>Cellular Signalling<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0898656814003544?via%3Dihub\" target=\"_blank\">10.1016\/j.cellsig.2014.11.008<\/a><br><br><strong>Eosinophils from patients with type 1 diabetes mellitus express high level of myeloid alpha-defensins and myeloperoxidase<\/strong><br><em>Authors:\u00a0<\/em>Ale\u0161 Neuwirth, <strong>Jan Dobe\u0161<\/strong>, Jana Oujezdsk\u00e1, Ond\u0159ej Ballek, Martina Bene\u0161ov\u00e1, Zden\u011bk Sumn\u00edk, Jana V\u010del\u00e1kov\u00e1, Stanislava Kolou\u0161kov\u00e1, Barbora Obermannov\u00e1, Michal Kol\u00e1\u0159, Kate\u0159ina Stechov\u00e1, Dominik Filipp<br><em>Published:\u00a0<\/em>2012<em>\u00a0in\u00a0<\/em><strong>Cellular Immunology<\/strong><br><em>DOI:\u00a0<\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0008874911003054?via%3Dihub\" target=\"_blank\">10.1016\/j.cellimm.2011.12.001<\/a><\/p><\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Selected publications: Segmented filamentous bacteria\u2013induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnoverAuthors: Tom\u00e1\u0161 Brabec, Martin Schwarzer, Katar\u00edna Kov\u00e1\u010dov\u00e1, Martina Dobe\u0161ov\u00e1, Dagmar Schierov\u00e1, Ji\u0159\u00ed B\u0159ezina, Iva Pac\u00e1kov\u00e1, Dagmar \u0160r\u016ftkov\u00e1, Osher Ben-Nun, Yael Goldfarb, Iva \u0160pl\u00edchalov\u00e1, Michal Kol\u00e1\u0159, Jakub Abramson, Dominik Filipp and Jan Dobe\u0161Published: 2023 in Journal of Experimental MedicineDOI: 10.1084\/jem.20230194 The emerging family [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-4983","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"admin","author_link":"https:\/\/web.natur.cuni.cz\/cellbiol\/dobeslab\/author\/admin\/"},"uagb_comment_info":0,"uagb_excerpt":"Selected publications: Segmented filamentous bacteria\u2013induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnoverAuthors: Tom\u00e1\u0161 Brabec, Martin Schwarzer, Katar\u00edna Kov\u00e1\u010dov\u00e1, Martina Dobe\u0161ov\u00e1, Dagmar Schierov\u00e1, Ji\u0159\u00ed B\u0159ezina, Iva Pac\u00e1kov\u00e1, Dagmar \u0160r\u016ftkov\u00e1, Osher Ben-Nun, Yael Goldfarb, Iva \u0160pl\u00edchalov\u00e1, Michal Kol\u00e1\u0159, Jakub Abramson, Dominik Filipp and Jan Dobe\u0161Published: 2023 in Journal of Experimental MedicineDOI: 10.1084\/jem.20230194 The emerging 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