Excited to share our new study, now out on bioRxiv: https://www.biorxiv.org/content/10.64898/2026.05.05.722849v1 In this work, we identify CK1α as a novel positive regulator of NOTCH1 signaling and uncover a previously unknown phosphorylation-dependent regulatory mechanism centered on N1ICD residue S1970. By combining cell biology, structural modeling, NMR, mass spectrometry, and Xenopus in vivo assays, we show how […]