Publications

Jan Mašek* , Iva Filipovic2, Noémi Van Hul2, Lenka Belicová2, Markéta Jiroušková, Daniel V Oliveira, Anna Maria Frontino, Simona Hankeova, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, Niklas K Björkström, Martin Gregor, Jan Dobeš, Emma R Andersson* – * co-corresponding,2 – shared 2nd author – Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects , EMBO Moleculr Medicine, October 2024. Available from: https://doi.org/10.1038/s44321-024-00145-8 ◇

Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects◇

Škarková, Aneta; Bizzarri, Mariano; Janoštiak, Radoslav; Mašek, Jan ; Rosel, Daniel; Brábek, Jan> – Educate, not kill: treating cancer without triggering its defenses , Trends in Molecular Medicine [review], April 2024. Available from: https://doi.org/10.1016/j.molmed.2024.04.003 ◇

Educate, not kill: treating cancer without triggering its defenses◇

Jan Mašek , Emma R. Andersson – Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome , Current Opinion in Cell Biology [review], January 2024. Available from: https://doi.org/10.1016/j.ceb.2023.102302 Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome◇

Preprint – Jan Mašek* , Iva Filipovic2, Simona Hankeová2, Jingyan He2, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Anna Maria Frontino, Fabio Turetti, Daniel V. Oliveira, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, Niklas K. Björkström, Martin Gregor, Jan Dobeš, Emma R. Andersson* – * co-corresponding, 2 – shared 2nd author – Protection from liver cancer in a mouse model of Alagille syndrome follows dysregulated differentiation of thymocytes and hepatocytes , bioRxiv [Internet], October 2022. Available from: https://doi.org/10.1101/2022.10.24.513578 ◇

Franziska Hildebrandt, Alma Andersson, Sami Saarenpää, Ludvig Larsson, Noémi Van Hul, Sachie Kanatani, Jan Masek, Ewa Ellis, Antonio Barragan, Annelie Mollbrink, Emma R. Andersson, Joakim Lundeberg, Johan Ankarklev – Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver , Nature Communications, December 2021. Available from: https://doi.org/10.1038/s41467-021-27354-w Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver◇

Postdoc

Mangold K, Mašek J*, He J*, Lendahl U, Fuchs E, Andersson ER. – Highly efficient manipulation of nervous system gene expression with NEPTUNE Cell Reports Methods. 2021 July 6. *equally second. Available from: https://doi.org/10.1016/j.crmeth.2021.100043Highly efficient manipulation of nervous system gene expression with NEPTUNE◇

Večeřa J, Procházková J, Šumberová V, Pánská V, Paculová H, Lánová MK, Mašek J, Bohačiaková D, Andersson ER & Pacherník J (2020) Hypoxia/Hif1α prevents premature neuronal differentiation of neural stem cells through the activation of Hes1. Stem Cell Res.Hypoxia/Hif1α prevents premature neuronal differentiation of neural stem cells through the activation of Hes1◇

Mašek J & Andersson ER (2017) The developmental biology of genetic Notch disorders. Development(review)The developmental biology of genetic Notch disorders◇

Andersson ER, Chivukula I V, Hankeova S, Sjöqvist M, Tsoi YL, Ramsköld D, Masek J, Elmansuri A, Hoogendoorn A, Vazquez E, Storvall H, Netušilová J, Huch M, Fischler B, Ellis E, Contreras A, Nemeth A, Chien KC, Clevers H, Sandberg R, et al (2017) Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations. GastroenterologyMouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations◇

PhD

Chodelkova O, Masek J, Korinek V, Kozmik Z & Machon O (2018) Tcf7L2 is essential for neurogenesis in the developing mouse neocortex. Neural Dev.Tcf7L2 is essential for neurogenesis in the developing mouse neocortex

Mašek J, Machoň O, Kořínek V, Taketo MM & Kozmik Z (2016) Tcf7l1 protects the anterior neural fold from adopting the neural crest fate. Development Tcf7l1 protects the anterior neural fold from adopting the neural crest fate

Machon O, Masek J, Machonova O, Krauss S & Kozmik Z (2015) Meis2 is essential for cranial and cardiac neural crest development. BMC Dev. Biol.Meis2 is essential for cranial and cardiac neural crest development◇

Pre-PhD

Buchtova M, Oralova V, Aklian A, Masek J, Vesela I, Ouyang Z, Obadalova T, Konecna Z, Spoustova T, Pospisilova T, Matula P, Varecha M, Balek L, Gudernova I, Jelinkova I, Duran I, Cervenkova I, Murakami S, Kozubik A, Dvorak P, et al (2015) Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage. Biochim. Biophys. Acta – Mol. Basis Dis.Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage◇

Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation◇Kříž V, Pospíchalová V, Mašek J, Kilander MBC, Slavík J, Tanneberger K, Schulte G, MacHala M, Kozubík A, Behrens J & Bryja V (2014) β-Arrestin promotes wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of amer1 protein. J. Biol. Chem.Β-Arrestin promotes wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of amer1 protein◇

Krejci P, Aklian A, Kaucka M, Sevcikova E, Prochazkova J, Masek JK, Mikolka P, Pospisilova T, Spoustova T, Weis M, Paznekas WA, Wolf JH, Gutkind JS, Wilcox WR, Kozubik A, Jabs EW, Bryja V, Salazar L, Vesela I & Balek L (2012) Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation. PLoS OneReceptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation◇

Cervenka I*, Wolf J*, Masek J*, Krejci P, Wilcox WR, Kozubik A, Schulte G, Gutkind JS & Bryja V (2011) Mitogen-Activated Protein Kinases Promote WNT/ β-Catenin Signaling via Phosphorylation of LRP6. Mol. Cell. Biol.Mitogen-activated protein kinases promote WNT/β-catenin signaling via phosphorylation of LRP6◇

Witte F, Bernatik O, Kirchner K, Masek J, Mahl A, Krejci P, Mundlos S, Schambony A, Bryja V & Stricker S (2010) Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2. FASEB J.Negative regulation of Wnt signaling mediated by CK1-phosphorylated dishevelled via Ror2◇