{"id":100,"date":"2020-10-19T19:14:46","date_gmt":"2020-10-19T19:14:46","guid":{"rendered":"http:\/\/www.maseklab.org\/?page_id=100"},"modified":"2026-02-10T10:30:44","modified_gmt":"2026-02-10T10:30:44","slug":"publications-2","status":"publish","type":"page","link":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/publications-2\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script> <strong> Fabio Turetti<\/strong>, Marek Dokoupil, Giovanna M Collu, Jakub Harno\u0161*, <strong> Jan Ma\u0161ek*<\/strong> &#8211; * co-corresponding <strong> &#8211; Decoding \u2018Wntch\u2019: the intertwined Wnt and Notch pathways in development and disease <\/strong>, Open Biology, January 2026. Available from: <a href=\"https:\/\/doi.org\/10.1098\/rsob.250282\">https:\/\/doi.org\/10.1098\/rsob.250282<\/a> \u25c7<\/a><p><\/p><a <a href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1098%2Frsob.250282\" data-popup=\"right\" data-size=\"large\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\">Decoding \u2018Wntch\u2019: the intertwined Wnt and Notch pathways in development and disease\u25c7<\/a><p><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script> <strong> Jan Ma\u0161ek*<\/strong> , Iva Filipovic2, No\u00e9mi Van Hul2, Lenka Belicov\u00e12, Mark\u00e9ta Jirou\u0161kov\u00e1,<strong> Daniel V Oliveira, Anna Maria Frontino<\/strong>, Simona Hankeova, Jingyan He,  <strong> Fabio Turetti<\/strong>, Afshan Iqbal, Igor \u010cervenka, Lenka Sarnov\u00e1, Elisabeth Verboven, Tom\u00e1\u0161 Brabec, Niklas K Bj\u00f6rkstr\u00f6m, Martin Gregor, Jan Dobe\u0161, Emma R Andersson* &#8211; * co-corresponding,2 &#8211; shared 2nd author <strong> &#8211; Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects <\/strong>, EMBO Molecular Medicine, October 2024. Available from: <a href=\"https:\/\/www.embopress.org\/doi\/full\/10.1038\/s44321-024-00145-8\">https:\/\/doi.org\/10.1038\/s44321-024-00145-8<\/a> \u25c7<\/a><p><\/p><a <a href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1038\/s44321-024-00145-8\" data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\">Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects\u25c7<\/a><p><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script> \u0160karkov\u00e1, Aneta; Bizzarri, Mariano; Jano\u0161tiak, Radoslav;<strong> Ma\u0161ek, Jan <\/strong>; Rosel, Daniel; Br\u00e1bek, Jan> <strong> &#8211;  \t\nEducate, not kill: treating cancer without triggering its defenses <\/strong>, Trends in Molecular Medicine [review], April 2024. Available from: <a href=\"https:\/\/doi.org\/10.1016\/j.molmed.2024.04.003\">https:\/\/doi.org\/10.1016\/j.molmed.2024.04.003<\/a> \u25c7<\/a><p><\/p><a <a href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1016%2Fj.molmed.2024.04.003\" data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\">Educate, not kill: treating cancer without triggering its defenses\u25c7<\/a><p><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script> <strong> Jan Ma\u0161ek <\/strong>, Emma R. Andersson <strong> &#8211;  \t\nJagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome <\/strong>, Current Opinion in Cell Biology [review], January 2024. Available from: <a href=\"https:\/\/doi.org\/10.1016\/j.ceb.2023.102302\">https:\/\/doi.org\/10.1016\/j.ceb.2023.102302<\/a> <a href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1016%2Fj.ceb.2023.102302\" data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\">Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome\u25c7<\/a><p><\/p>\n\n\n\n\n\n<p><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>Franziska Hildebrandt, Alma Andersson, Sami Saarenp\u00e4\u00e4, Ludvig Larsson, No\u00e9mi Van Hul, Sachie Kanatani, <strong>Jan Masek<\/strong>, Ewa Ellis, Antonio Barragan, Annelie Mollbrink, Emma R. Andersson, Joakim Lundeberg, Johan Ankarklev &#8211; <strong>  \t\nSpatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver  <\/strong>, Nature Communications, December 2021. Available from: <a href=\"https:\/\/doi.org\/10.1038\/s41467-021-27354-w\">https:\/\/doi.org\/10.1038\/s41467-021-27354-w<\/a><a href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1038\/s41467-021-27354-w\" data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\"> \t\nSpatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver\u25c7<\/a><p><\/p>\n\n\n\n<p><strong><span class=\"has-inline-color has-cyan-bluish-gray-color\">Postdoc<\/span><\/strong><\/p>\n\n\n<div class=\"wp-block-image is-style-default\">\n<figure class=\"alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"231\" height=\"300\" src=\"http:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-content\/uploads\/2021\/09\/neptune-cover-e1632465533528.jpg\" alt=\"\" class=\"wp-image-503\" style=\"width:116px;height:150px\"\/><\/figure>\n<\/div>\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>Mangold K, <strong>Ma\u0161ek J<\/strong>*, He J*, Lendahl U, Fuchs E, Andersson ER. &#8211; <strong> Highly efficient manipulation of nervous system gene expression with NEPTUNE <\/strong> Cell Reports Methods. 2021 July 6. *equally second. Available from: <a href=\"https:\/\/doi.org\/10.1016\/j.crmeth.2021.100043\">https:\/\/doi.org\/10.1016\/j.crmeth.2021.100043<\/a><a href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1016%2Fj.crmeth.2021.100043\" data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\">Highly efficient manipulation of nervous system gene expression with NEPTUNE\u25c7<\/a><p><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>Ve\u010de\u0159a J, Proch\u00e1zkov\u00e1 J, \u0160umberov\u00e1 V, P\u00e1nsk\u00e1 V, Paculov\u00e1 H, L\u00e1nov\u00e1 MK, <strong>Ma\u0161ek J<\/strong>, Boha\u010diakov\u00e1 D, Andersson ER &amp; Pachern\u00edk J (2020) <strong> Hypoxia\/Hif1\u03b1 prevents premature neuronal differentiation of neural stem cells through the activation of Hes1.<\/strong> Stem Cell Res.<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1016\/j.scr.2020.101770\">Hypoxia\/Hif1\u03b1 prevents premature neuronal differentiation of neural stem cells through the activation of Hes1\u25c7<\/a><p><\/p>\n\n\n\n<p><strong>Ma\u0161ek J<\/strong> &amp; Andersson ER (2017)<strong> The developmental biology of genetic Notch disorders. <\/strong>Development(review)<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1242\/dev.148007\">The developmental biology of genetic Notch disorders\u25c7<\/a><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>\n\n\n\n<p>Andersson ER, Chivukula I V, Hankeova S, Sj\u00f6qvist M, Tsoi YL, Ramsk\u00f6ld D,<strong> Masek J<\/strong>, Elmansuri A, Hoogendoorn A, Vazquez E, Storvall H, Netu\u0161ilov\u00e1 J, Huch M, Fischler B, Ellis E, Contreras A, Nemeth A, Chien KC, Clevers H, Sandberg R, et al (2017) <strong>Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations. <\/strong>Gastroenterology<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1053\/j.gastro.2017.11.002\">Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations\u25c7<\/a><\/p>\n\n\n\n<p><strong><span class=\"has-inline-color has-cyan-bluish-gray-color\">PhD<\/span><\/strong><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>\n\n\n\n<p>Chodelkova O,<strong> Masek J<\/strong>, Korinek V, Kozmik Z &amp; Machon O (2018) <strong>Tcf7L2 is essential for neurogenesis in the developing mouse neocortex.<\/strong> Neural Dev.<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1186\/s13064-018-0107-8\">Tcf7L2 is essential for neurogenesis in the developing mouse neocortex<\/a><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>\n\n\n\n<p><strong>Ma\u0161ek J<\/strong>, Macho\u0148 O, Ko\u0159\u00ednek V, Taketo MM &amp; Kozmik Z (2016) <strong>Tcf7l1 protects the anterior neural fold from adopting the neural crest fate.<\/strong> Development <a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"false\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1242\/dev.132357\">Tcf7l1 protects the anterior neural fold from adopting the neural crest fate<\/a><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>\n\n\n\n<p>Machon O,<strong> Masek J<\/strong>, Machonova O, Krauss S &amp; Kozmik Z (2015) <strong>Meis2 is essential for cranial and cardiac neural crest development.<\/strong> BMC Dev. Biol.<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1186\/s12861-015-0093-6\">Meis2 is essential for cranial and cardiac neural crest development\u25c7<\/a><\/p>\n\n\n\n<p><strong><span class=\"has-inline-color has-cyan-bluish-gray-color\">Pre-PhD<\/span><\/strong><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>\n\n\n\n<p>Buchtova M, Oralova V, Aklian A, <strong>Masek J<\/strong>, Vesela I, Ouyang Z, Obadalova T, Konecna Z, Spoustova T, Pospisilova T, Matula P, Varecha M, Balek L, Gudernova I, Jelinkova I, Duran I, Cervenkova I, Murakami S, Kozubik A, Dvorak P, et al (2015) <strong>Fibroblast growth factor and canonical WNT\/\u03b2-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage. <\/strong>Biochim. Biophys. Acta \u2013 Mol. Basis Dis.<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1016\/j.bbadis.2014.12.020\">Fibroblast growth factor and canonical WNT\/\u03b2-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage\u25c7<\/a><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>\n\n\n\n<p>Receptor tyrosine kinases activate canonical WNT\/\u03b2-catenin signaling via MAP kinase\/LRP6 pathway and direct \u03b2-catenin phosphorylation\u25c7K\u0159\u00ed\u017e V, Posp\u00edchalov\u00e1 V, <strong>Ma\u0161ek J<\/strong>, Kilander MBC, Slav\u00edk J, Tanneberger K, Schulte G, MacHala M, Kozub\u00edk A, Behrens J &amp; Bryja V (2014)<strong> \u03b2-Arrestin promotes wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of amer1 protein.<\/strong> J. Biol. Chem.<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1074\/jbc.M113.498444\">\u0392-Arrestin promotes wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of amer1 protein\u25c7<\/a><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>\n\n\n\n<p>Krejci P, Aklian A, Kaucka M, Sevcikova E, Prochazkova J, <strong>Masek JK<\/strong>, Mikolka P, Pospisilova T, Spoustova T, Weis M, Paznekas WA, Wolf JH, Gutkind JS, Wilcox WR, Kozubik A, Jabs EW, Bryja V, Salazar L, Vesela I &amp; Balek L (2012) <strong>Receptor tyrosine kinases activate canonical WNT\/\u03b2-catenin signaling via MAP kinase\/LRP6 pathway and direct \u03b2-catenin phosphorylation.<\/strong> PLoS One<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1371\/journal.pone.0035826\">Receptor tyrosine kinases activate canonical WNT\/\u03b2-catenin signaling via MAP kinase\/LRP6 pathway and direct \u03b2-catenin phosphorylation\u25c7<\/a><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>\n\n\n\n<p>Cervenka I*, Wolf J*,<strong> Masek J*<\/strong>, Krejci P, Wilcox WR, Kozubik A, Schulte G, Gutkind JS &amp; Bryja V (2011) <strong>Mitogen-Activated Protein Kinases Promote WNT\/ \u03b2-Catenin Signaling via Phosphorylation of LRP6. <\/strong>Mol. Cell. Biol.<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1128%2Fmcb.00550-10\">Mitogen-activated protein kinases promote WNT\/\u03b2-catenin signaling via phosphorylation of LRP6\u25c7<\/a><\/p>\n\n\n\n<script type=\"text\/javascript\" src=\"\/\/cdn.plu.mx\/widget-popup.js\"><\/script>\n\n\n\n<p>Witte F, Bernatik O, Kirchner K, <strong>Masek J<\/strong>, Mahl A, Krejci P, Mundlos S, Schambony A, Bryja V &amp; Stricker S (2010) <strong>Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2. <\/strong>FASEB J.<a data-popup=\"right\" data-size=\"medium\" class=\"plumx-plum-print-popup\" data-site=\"plum\" data-hide-when-empty=\"true\" href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1096%2Ffj.09-150615\">Negative regulation of Wnt signaling mediated by CK1-phosphorylated dishevelled via Ror2\u25c7<\/a><\/p>\n\n\n\n<pre class=\"wp-block-preformatted\"><code data-test=\"widget-embed-code\"><\/code><\/pre>\n\n\n\n<p><\/p>\n\n\n\n<br><br>\n","protected":false},"excerpt":{"rendered":"<p>Fabio Turetti, Marek Dokoupil, Giovanna M Collu, Jakub Harno\u0161*, Jan Ma\u0161ek* &#8211; * co-corresponding &#8211; Decoding \u2018Wntch\u2019: the intertwined Wnt and Notch pathways in development and disease , Open Biology, January 2026. Available from: https:\/\/doi.org\/10.1098\/rsob.250282 \u25c7<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-100","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"janmas","author_link":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/author\/janmas\/"},"uagb_comment_info":0,"uagb_excerpt":"Fabio Turetti, Marek Dokoupil, Giovanna M Collu, Jakub Harno\u0161*, Jan Ma\u0161ek* &#8211; * co-corresponding &#8211; Decoding \u2018Wntch\u2019: the intertwined Wnt and Notch pathways in development and disease , Open Biology, January 2026. Available from: https:\/\/doi.org\/10.1098\/rsob.250282 \u25c7","_links":{"self":[{"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/pages\/100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/comments?post=100"}],"version-history":[{"count":49,"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/pages\/100\/revisions"}],"predecessor-version":[{"id":5886,"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/pages\/100\/revisions\/5886"}],"wp:attachment":[{"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/media?parent=100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}