{"id":107,"date":"2020-10-19T19:29:55","date_gmt":"2020-10-19T19:29:55","guid":{"rendered":"http:\/\/www.maseklab.org\/?page_id=107"},"modified":"2025-08-06T07:57:11","modified_gmt":"2025-08-06T07:57:11","slug":"about-the-lab-2","status":"publish","type":"page","link":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/about-the-lab-2\/","title":{"rendered":"About the lab"},"content":{"rendered":"\n
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Multicellular organisms can exist only thanks to the signaling pathways, the vast networks of biochemical cascades intertwined with every aspect of cellular life. The major signaling pathways, such as Notch, Wnt, FGF, JAK\/STAT, and TGF-\u03b2, act as key regulators of embryonic development and drivers of genetic disorders and cancer when deregulated.<\/p>\n<\/div><\/div>\n\n\n\n

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Unlike the other pathways, Notch signaling occurs only after direct cell-cell contact and lacks the amplification steps, making it highly sensitive to perturbations. Almost two decades have passed since the discovery of the potential signaling crosstalk with Wnt components, yet the mechanisms and biological functions remain elusive.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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We aim to functionally test the \u201cNon-canonical\u201d signaling potential of the Notch Ligands in mammals. We take advantage of existing, rare genetic disorders causing mutations in key motifs of the Notch ligand Jagged1, recapitulating the pathology in vivo <\/em>using the mouse model, and investigate the \u201cNon-canonical\u201d aspect of Notch ligand signaling. The focus of our research holds promise for the future development of therapeutics for Notch-driven diseases.<\/p>\n\n\n

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Multicellular organisms can exist only thanks to the signaling pathways, the vast networks of biochemical cascades intertwined with every aspect of cellular life. The major signaling pathways, such as Notch, Wnt, FGF, JAK\/STAT, and TGF-\u03b2, act as key regulators of embryonic development and drivers of genetic disorders and cancer when deregulated. Unlike the other pathways, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-107","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"janmas","author_link":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/author\/janmas\/"},"uagb_comment_info":0,"uagb_excerpt":"Multicellular organisms can exist only thanks to the signaling pathways, the vast networks of biochemical cascades intertwined with every aspect of cellular life. The major signaling pathways, such as Notch, Wnt, FGF, JAK\/STAT, and TGF-\u03b2, act as key regulators of embryonic development and drivers of genetic disorders and cancer when deregulated. Unlike the other pathways,…","_links":{"self":[{"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/pages\/107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/comments?post=107"}],"version-history":[{"count":51,"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/pages\/107\/revisions"}],"predecessor-version":[{"id":5865,"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/pages\/107\/revisions\/5865"}],"wp:attachment":[{"href":"https:\/\/web.natur.cuni.cz\/cellbiol\/maseklab\/wp-json\/wp\/v2\/media?parent=107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}