Publications

Kotora, M.; Hocek, M.; Turek, P.; Pohl, R.; Klepetářová, B.; Votruba, I.; Opekar, S. [2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with α,ω-Diynes. HETEROCYCLES 2010, 82 (1), 895 DOI: 10.3987/COM-10-S(E)56.

Matyašovský, J.; Pohl, R.; Hocek, M. 2-Allyl- and Propargylamino-dATPs for Site-Specific Enzymatic Introduction of a Single Modification in the Minor Groove of DNA. Chemistry-a European Journal 2018, 24 (56), 14938-14941 DOI: 10.1002/chem.201803973.

Matyašovský, J.; Perlíková, P.; Malnuit, V.; Pohl, R.; Hocek, M. 2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove. Angewandte Chemie International Edition 2016, 55 (51), 15856-15859 DOI: 10.1002/anie.201609007.

Bosáková, A.; Perlíková, P.; Tichý, M.; Pohl, R.; Hocek, M. 6-Aryl-4-amino-pyrimido[4,5-b]indole 2′-deoxyribonucleoside triphosphates (benzo-fused 7-deaza-dATP analogues): Synthesis, fluorescent properties, enzymatic incorporation into DNA and DNA-protein binding study. Bioorganic & Medicinal Chemistry 2016, 24 (19), 4528-4535 DOI: 10.1016/j.bmc.2016.07.054.

Slavíčková, M.; Pohl, R.; Hocek, M. Additions of Thiols to 7-Vinyl-7-deazaadenine Nucleosides and Nucleotides. Synthesis of Hydrophobic Derivatives of 2′-Deoxyadenosine, dATP and DNA. The Journal of Organic Chemistry 2016, 81 (22), 11115-11125 DOI: 10.1021/acs.joc.6b02098.

Dadová, J.; Vidláková, P.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M. Aqueous Heck Cross-Coupling Preparation of Acrylate-Modified Nucleotides and Nucleoside Triphosphates for Polymerase Synthesis of Acrylate-Labeled DNA. The Journal of Organic Chemistry 2013, 78 (19), 9627-9637 DOI: 10.1021/jo4011574.

Balintová, J.; Špaček, J.; Pohl, R.; Brázdová, M.; Havran, L.; Fojta, M.; Hocek, M. Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA–protein interactions. Chem. Sci. 2015, 6 (1), 575-587 DOI: 10.1039/C4SC01906G.

Dadová, J.; Vrábel, M.; Adámik, M.; Brázdová, M.; Pohl, R.; Fojta, M.; Hocek, M. Azidopropylvinylsulfonamide as a New Bifunctional Click Reagent for Bioorthogonal Conjugations: Application for DNA-Protein Cross-Linking. Chemistry - A European Journal 2015, 21 (45), 16091-16102 DOI: 10.1002/chem.201502209.

Balintová, J.; Plucnara, M.; Vidláková, P.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M. Benzofurazane as a New Redox Label for Electrochemical Detection of DNA: Towards Multipotential Redox Coding of DNA Bases. Chemistry - A European Journal 2013, 19 (38), 12720-12731 DOI: 10.1002/chem.201301868.

Dziuba, D.; Pohl, R.; Hocek, M. Bodipy-Labeled Nucleoside Triphosphates for Polymerase Synthesis of Fluorescent DNA. Bioconjugate Chemistry 2014, 25 (11), 1984-1995 DOI: 10.1021/bc5003554.

Güixens-Gallardo, P.; Zawada, Z.; Matyašovský, J.; Dziuba, D.; Pohl, R.; Kraus, T.; Hocek, M. Brightly Fluorescent 2 '-Deoxyribonucleoside Triphosphates Bearing Methylated Bodipy Fluorophore for in Cellulo Incorporation to DNA, Imaging, and Flow Cytometry. Bioconjugate Chemistry 2018, 29 (11), 3906-3912 DOI: 10.1021/acs.bioconjchem.8b00721.

Hocek, M.; Ćerňová, M.; Pohl, R.; Klepetářová, B. C-H Trifluoromethylations of 1,3-Dimethyluracil and Reactivity of the Products in C-H Arylations. HETEROCYCLES 2014, 89 (5), 1159 DOI: 10.3987/COM-14-12958.

Báječný, M.; Beneš, J.; Czernek, J.; Dunlop, D.; Francová, P.; Groborz, O.; Heizer, T.; Hobza, P.; Hrubý, M.; Kolouchová, K.; et al. Chelating Polymers for Hereditary Hemochromatosis Treatment. Macromolecular Bioscience 2020, 20 (12), nestránkováno DOI: 10.1002/mabi.202000254.

Olszewska, A.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. Chloroacetamide-Linked Nucleotides and DNA for Cross-Linking with Peptides and Proteins. Bioconjugate Chemistry 2016, 27 (9), 2089-2094 DOI: 10.1021/acs.bioconjchem.6b00342.

Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M. Cobalt‐Induced Synthesis of 6‐(Pyridin‐2‐yl)purines by Microwave‐Enhanced [2+2+2] Cyclotrimerization. European Journal of Organic Chemistry 2008, 2008 (19), 3335-3343 DOI: 10.1002/ejoc.200800205.

Botha, F.; Slavíčková, M.; Pohl, R.; Hocek, M. Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides. Org. Biomol. Chem. 2016, 14 (42), 10018-10022 DOI: 10.1039/C6OB01917J.

Parkan, K.; Pohl, R.; Kotora, M. Cross-Coupling Reaction of Saccharide-Based Alkenyl Boronic Acids with Aryl Halides: The Synthesis of Bergenin. Chemistry - A European Journal 2014, 20 (15), 4414-4419 DOI: 10.1002/chem.201304304.

Klečka, M.; Pohl, R.; Čejka, J.; Hocek, M. Direct C–H sulfenylation of purines and deazapurines. Organic & Biomolecular Chemistry 2013, 11 (31), 5189 DOI: 10.1039/c3ob40881g.

A. Downey, M.; Richter, C.; Pohl, R.; Mahrwald, R.; Hocek, M. Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose. Organic Letters 2015, 17 (18), 4604-4607 DOI: 10.1021/acs.orglett.5b02332.

Kielkowski, P.; Cahová, H.; Pohl, R.; Hocek, M. Flexible double-headed cytosine-linked 2′-deoxycytidine nucleotides. Synthesis, polymerase incorporation to DNA and interaction with DNA methyltransferases. Bioorganic & Medicinal Chemistry 2016, 24 (6), 1268-1276 DOI: 10.1016/j.bmc.2016.01.057.

Ćerňová, M.; Pohl, R.; Klepetářová, B.; Hocek, M. A General Regioselective Synthesis of 2,4-Diarylpyrimidines from 2- Thiouracil through Two Orthogonal Cross-Coupling Reactions. Synlett 2012, 23 (09), 1305-1308 DOI: 10.1055/s-0031-1290826.

Riedl, J.; Ménová, P.; Pohl, R.; Orság, P.; Fojta, M.; Hocek, M. GFP-like Fluorophores as DNA Labels for Studying DNA–Protein Interactions. The Journal of Organic Chemistry 2012, 77 (18), 8287-8293 DOI: 10.1021/jo301684b.

Ghosh, K.; Perlíková, P.; Havlicek, V.; Yang, C.; Pohl, R.; Tloušťová, E.; Hodek, J.; Gurska, S.; Džubák, P.; Hajdúch, M.; et al. Isomeric Naphtho-Fused 7-Deazapurine Nucleosides and Nucleotides: Synthesis, Biological Activity, Photophysical Properties and Enzymatic Incorporation to Nucleic Acids. European Journal of Organic Chemistry 2018, No. 37, 5092-5108 DOI: 10.1002/ejoc.201800165.

Riedl, J.; Pohl, R.; Ernsting, N. P.; Orság, P.; Fojta, M.; Hocek, M. Labelling of nucleosides and oligonucleotides by solvatochromic 4-aminophthalimide fluorophore for studying DNA–protein interactions. Chemical Science 2012, 3 (9), 2797 DOI: 10.1039/c2sc20404e.

Simonova, A.; Balintová, J.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M. Methoxyphenol and Dihydrobenzofuran as Oxidizable Labels for Electrochemical Detection of DNA. ChemPlusChem 2014, n/a-n/a DOI: 10.1002/cplu.201402194.