Publications

Selected papers:

2020

  • Skalova T., Lengalova A., Dohnálek J., Harlos K., Mihalcin P., Kolenko P., Stranava M., Bláha J., Shimizu T., Martínková M.: Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensor AfGcHK abolishes bacterial signal transduction, J. Biol. Chem. 2020, 295, 1587–1597 10.1074/jbc.RA119.011574

2019

  • Shimizu T., Lengalova A., Martínek V., Martínková M. (2019) Heme: Emergent roles of heme in signal transduction, functional regulation and as catalytic centres, Chem. Soc. Rev., 48: 5624-5657 https://doi.org/10.1039/c9cs00268e
  • Lengalova A., Fojtikova-Proskova V, Vavra J, Martínek V, Stranava M, Shimizu T, Martinkova M (2019) Kinetic Analysis of a Globin-Coupled Diguanylate Cyclase, YddV: Effects of Heme Iron Redox State, Axial Ligands, and Heme Distal Mutations on Catalysis, Journal of Inorganic Biochemistry, 201: 110833.
  • Indra R, Černá T, Heger Z, Hraběta J, Wilhelm M, Dostálová S, Lengálová A, Martínková M, Adam V, Eckschlager T, Schmeiser HH, Arlt VM, Stiborová M (2019) Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells, Toxicology, 419: 40–54.

2018

  • Stiborová M, Dračínská H, Bořek-Dohalská L, Klusoňová Z, Holecová J, Martínková M, Schmeiser HH, Arlt VM (2018) Exposure to Endocrine Disruptors 17alpha-Ethinylestradiol and Estradiol Influences Cytochrome P450 1A1-Mediated Genotoxicity of Benzo[a]Pyrene and Expression of This Enzyme in Rats, Toxicology, 400401: 48–56

2017

  • Stranava M, Man P, Skálová T, Kolenko P, Blaha J, Fojtikova V, Martínek V, Dohnálek J, Lengalova A, Rosůlek M, Shimizu T, Martinkova M (2017) Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction, J Biol Chem 29220921-20935
  • Mináriková M, Fojtikova V, Vyskočilová E, Sedláček J, Šikut M, Borek-Dohalska L, Stiborová M, Martinkova M (2017) The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: a comparative study, Environ Toxicol Phar 52: 214-220

2016

  • Fojtikova V, Bartosova M, Man P, Stranava M, Shimizu T, Martinkova M (2016) Effects of hydrogen sulfide on the heme coordination structure and catalytic activity of the globin-coupled oxygen sensor AfGcHK, Biometals 29: 715-729
  • Stranava M, Martinek V, Man P, Fojtikova V, Kavan D, Vaněk O, Shimizu T, Martinkova M (2016) Structural Characterization of the Heme-based Oxygen Sensor, AfGcHK, its Interactions with the Cognate Response Regulator, and their Combined Mechanism of Action in a Bacterial Two-component Signaling System. Proteins, 84: 1375-89
  • Kuipers K, Gallay C, Martínek V, Rohde M, Martínková M, van der Beek SL, Jong WS, Venselaar H, Zomer A, Bootsma H, Veening JW, de Jonge MI (2016) Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniaeMol Microbiol 101: 12-26
  • Lambry J-Ch, Stranava M, Lobato L, Martinkova MShimizu T, Liebl U, Vos MH (2016) Ultrafast Spectroscopy Evidence for Picosecond Ligand Exchange at the Binding Site of a Heme Protein: Heme-based Sensor YddV. J Phys Chem Lett 7: 69–74

2015

  • Fojtikova VStranava M, Vos M H, Liebl U,  Hraníček J, Kitanishi K, Shimizu TMartinkova M (2015) Kinetic Analysis of a Globin-coupled Histidine Kinase, AfGcHK: Effects of the Heme Iron Complex, Response Regulator and Metal Cations on Autophosphorylation Activity. Biochemistry 54: 5017–5029
  • Pavlou A, Martínková MShimizu T, Kitanishi K, Stranava M, Loullis A, Pinakoulaki E (2015)  Probing the ligand recognition and discrimination environment of the globin-coupled oxygen sensor protein YddV by FTIR and time-resolved step-scan FTIR spectroscop.Phys Chem Chem Phys 17: 17007-17015
  • Yan F, Fojtikova V, Man P, Stráňava MMartínková M, Du Y, Huang D, Shimizu T (2015)  Catalytic Enhancement of the Heme-based Oxygen-Sensing Phosphodiesterase EcDOS by Hydrogen Sulfide Is Caused by Changes in Heme Coordination Structure, BioMetals 28: 637-652
  • Shimizu T, Yan F, Huang D, Stráňava M, Bartošová M, Fojtíková V, Martínková M (2015) Molecular Characteristics of Heme-based Gas (O2, NO and CO) Sensors. Chem Rev 115: 6491−6533

2014

  • Anzenbacher P, Marchal S, Palacký J, Anzenbacherová E, Domaschke T, Lange R, Shimizu T, Kitanishi K, Stranava M, Stiborová M, Martinkova M (2014) Pressure effects reveal that heme iron-redox change significantly affects the protein flexibility of the heme domains of heme-based oxygen sensors, Ec DOS and YddV. FEBS J 281: 5208–5219
  • Stranava M, Martínková M, Stiborová M, Man P, Kitanishi K, Muchová L, Vítek L, Martínek VShimizu T (2014) Introduction of water into the heme distal side by Leu65 mutations of an oxygen sensor, YddV, generates verdoheme and carbon monoxide, exerting the heme oxygenase reaction. J Inorg Biochem 140: 29-38

2013

  • Du Y, Liu G, Yan, Y Huang D, Luo W, Martinkova M, Man P, Shimizu T (2013) Conversion of a Heme-based Oxygen Sensor to a Heme Oxygenase by Hydrogen Sulfide: Effects of Mutations in the Heme Distal Side of a Heme-based  Oxygen Sensor Phosphodiesterase (Ec DOS). BioMetals 26: 839–852
  • Martinkova M, Kitanishi K, and Shimizu T (2013) Heme-Based Globin-Coupled Oxygen Sensors: Linking Oxygen Binding to Functional Regulation of Diguanylate Cyclase, Histidine Kinase and Methyl-accepting Chemotaxis. J Biol Chem 288: 27702–27711