TOXCON 2011 Prague
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Předpokládaný časový plán konference
- Registrace – úterý 17.5.2011 od 9:00 hodin
- Zahájení – 17.5.2011 ve 14:30 hodin
- Ukončení – pátek 20.5.2011 v 16:00 hodin
Podrobný program konference
Tuesday – May 17, 2011
9:00 – 19:00
TOXCON 2011 Registration
14:30 – 14:45
Official Opening of TOXCON 2011
14:45 – 18:00
Session 1: Mechanisms of Toxicity
Chairpersons: Pavel Anzenbacher & Marie Stiborová
14:45 – 16:45
14:45 – 15:15 Prediction of cytochrome P450-drug interactions
Hudeček J., Hodek P., Stiborova M.
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
15:15 – 15:45 ROLE OF ENZYMES OF II. PHASE IN METABOLISM AND TOXICITY OF XENOBIOTICS
Anzenbacherova E., Anzenbacher P., Jančová P., Anzenbacherova E. Jr.
Department of Medical Chemistry, Palacky University, Hnevotinska 3, 779 00 Olomouc, Czech Republic
15:45 – 16:15 Metabolism of aristolochic acid I dictates its nephrotoxic and carcinogenic effects
Stiborová M., Levová K., Bárta F., Martínek V., Frei E., Arlt V.M., Phillips D.H., Schmeiser H.H.
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
16:15 – 16:45 PROBIOTICS IN THE GASTROINTESTINAL TRACT AND THEIR INFLUENCE ON DRUG METABOLISM
Anzenbacher P., Matušková Z., Anzenbacherová E., Kmoníčková E. , Zídek Z., Tlaskalová-Hogenová H.
Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 779 00 Olomouc, Czech Republic
16:45-17:00 BREAK
Session 1: Mechanisms of Toxicity - continued
Chairpersons: Jiří Hudeček & Petr Hodek
17:00 – 18:00
17:00-17:20 THE ROLE OF BETA-NAPHTHOFLAVONE IN BAP AND PHIP-MEDIATED GENOTOXICITY
Hodek P., Křížková J., Arlt V.M., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
17:20 – 17:40 DNA ADDUCTS DERIVED FROM BENZENE: FORMATION, METABOLIC TRANSFORMATION, AND EXCRETION.
Linhart I., Mikeš P., Míčová K., Krouželka J., Králík A., Frantík E., Mráz J.
Department of Organic Chemistry, Institute of Chemical Technology, Prague, Technická 190, 166 28 Prague, Czech Republic
17:40 – 18:00 Glycosylation protects proteins against free radicals generated from toxic xenobiotics. A novel role for carbohydrate moieties in glycoproteins
Martínek V., Sklenář J., Šulc M., Bezouška K., Frei E., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 12840 Prague 2, Czech Republic
Wednesday – May 18, 2011
8:30 – 11:30
Session 2: Pharmacology & Oxidative Stress
Chairpersons: Jaroslav Květina & Radomír Nosáľ
8:30 – 10:10
8:30 – 9:00 On the pharmacology of oxidative burst of neutrophils.
Nosáľ R., Drábiková K., Harmatha J., Jančinová V., Mačičková T.,Pečivová J., Perečko T.
Institute of Experimental Pharmacology and Toxicology SAS Bratislava,Slovakia,
9:00 – 9:30 ELECTROGASTROGRAPHY IN EXPERIMENAL PIGS: INFLUENCE OF GASTROINTESTINAL LESIONS (INDUCED BY DEXTRAN-SODIUM-SULFATE) ON ERYTHROMYCIN-PROKINETIC EFFECT
Květina J., Kuneš M., Bureš J., Tachecí I.
Institute of Experimental Biopharmaceutics, Joint Research Centre of Czech Academy of Sciences and PRO.MED.CS Praha a.s., Hradec Králové, Czech Republic
9:30 – 9:50 Role of oxidative stress-modifying genes in prognosis of breast carcinoma
Souček P., Hubáčková M., Václavíková R., Ehrlichová M., Vrána D., Mrhalová M., Kubáčková K., Pecha V., Kodet R., Trnková M., Gut I.
Toxicogenomics Unit, National Institute of Public Health, Srobarova 48, Prague 10,
100 42, Czech Republic,
9:50 – 10:10 Radical degradation OF high-molar-mass hyaluronan induced by Weissberger oxidative system. Testing of thiol compounds in function of antioxidants
Valachová K., Hrabárová E., Juránek I., Šoltés L.
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 84104 Bratislava, Slovakia
10:10-10:30 BREAK
Session 2: Pharmacology & Oxidative Stress - continued
Chairpersons: Katarína Valachová & Pavel Souček
10:30 – 11:30
10:30 – 10:50 INCREASED OXIDATIVE STRESS MARKERS IN PATIENTS WITH LONG-LASTING HIGH 2,3,7,8-TETRACHLORO-DIBENZO-p-DIOXIN PLASMA LEVEL
Pelclová D., Navrátil T. , Fenclová Z., Ridzoň P., Urban P., Kupka K., Zikán V.., Syslová K., Kuzma M., Kačer P.
Department of Occupational Medicine, 1stMedical Faculty, Charles University and General Teaching Hospital, Na Bojišti 1, 120 00 Prague, Czech Republic
10:50 – 11:10 Effect of natural substances - arbutin, curcumin, rosmarinic acid and extract of Mentha x villosa on isolated rat heart and blood-vessels.
Brosková Z., Sotníková R., Knezl V.
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovak Republic
11:10 – 11:30 EARLY STAGE OF THE ACUTE PHASE OF JOINT INFLAMMATION. IN VITRO TESTING OF BUCILLAMINE AND ITS OXIDIZED METABOLITE SA981 IN FUNCTION OF ANTIOXIDANTS
Baňasová M., Valachová K., Hrabárová E., Priesolová E., Nagy M., Juránek I., Šoltés L.
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, SK-84104, Bratislava, Slovakia
11:30-13:00 LUNCH
13:00 – 14:00
Session 3: Military Toxicology
Chairpersons: Jiří Kassa & Rudolf Štětina
13:00 – 14:00
13:00 – 13:20 From the research of cholinesterase reactivators to the effective therapy of organophosphate/nerve agent poisoning.
Bajgar J., Kassa J.
Department of Toxicology, Faculty of Military Health Science, University of Defence
Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
13:20 – 13:40 Alzheimer’s disease drug huperzine: oxidative stress responses after the therapeutic dose and overdosing in laboratory animal model
Pohanka M., Sobotka J., Drtinova L., Hrabinova M., Pikula J., Kuca K.
Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 50001 Hradec Kralove, Czech Republic
13:40 – 14:00 The assay for measuring the individual capacity of nucleotide excision DNA repair.
Štětina R., Fikrová P., Svobodová H., Jošt P., Strejčková L.
Faculty of Military Medical Sciences, University Defence, Department of Toxicology, Třebešská 1575, 50001 Hradec Králové
14:00-14:15 BREAK
14.15 – 15:25
Session 4: Developmental Toxicology
Chairpersons: Eduard Ujházy & Mojmír Mach
14.15 – 15:25
14.15 – 14:45 THE EVALUATION OF SUBCHRONIC ASPHYXIA ON PRENATAL DEVELOPMENT IN RATS
Ujházy E., Dubovický M., Navarová J., Brucknerová I., M. Mach
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Dúbravská cesta 9, 841 04 Bratislava, Slovakia
14.45 – 15:05 The SSRI/SNRI antidepressant drugs in pregnancy and their possible unfavorable effects on embryo-fetal development
Dubovický M., Ujházy E., Bezek Š., Mach M.
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovak Republic
15.05 – 15:25 ANTIDEPRESSANT DRUG EXPOSURE DURING PREGNANCY. CZTIS SMALL PROSPECTIVE STUDY.
Maňáková E., Hubičková L.
Department of Histology and Embryology, 3rd Faculty of Medicine, Charles University, Ruská 87, Prague 10, Czech Republic
15:25-15:45 BREAK
15.45 – 16:45
Session 5: Environmental Toxicology
Chairpersons: Zdeňka Svobodová & Kamila Novotná (Kružíková)
15.45 – 16:45
15.45 – 16:05 Assessment of Svitava and Svratka rivers contamination by organic polutants using fish biochemical markers
Blahová J. , Kružíková K., Havelková M., Halířová J.2, Hypr D. , Stierand P., Jurčíková J., Kasíková B., Grabic R., Ocelka T., Haruštiaková D., Svobodová Z.
Department of Veterinary Public Health and Toxicology, University of Veterinary Public Health and Ecology, Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, Brno, 612 42, Czech Republic
16.05 – 16:25 METALS AS A CAUSE OF OXIDATIVE STRESS IN FISH - A REVIEW
Ševčíková M., Modrá H., Slaninová A., Svobodová Z.
Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1/3, 612 42 Brno, Czech Republic
16.25 – 16:45 Mallard (Anas platyrhynchos) as a bioindicator of lead contamination of aquatic environment.
Hutařová Z., Večerek V., Čelechovská O., Svobodová Z.
Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygieneand Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1/3, 612 42 Brno, Czech Republic.
18:30 Social Evening – Banquet
Thursday – May 19, 2011
8:30 – 10:55
Session 6: Genotoxicity
Chairpersons: Ľudovít Mušák & Pavel Vodička
8:30 – 9:40
8:30 – 9:00 INDIVIDUAL SUSCEPTIBILITY FACTORS IN GENOTOXICITY AND CARCINOGENICITY OF XENOBIOTICS
Vodicka P., Naccarati A., Pardini B., Polakova V., Hanova M., Slyskova J., Vodickova L
Inst. Exper. Med., Acad. Sci. Czech Rep., Videnska 1083, 14200 Prague 4, Czech Rep.,
9:00 – 9:20 OCCURRENCE OF CHROMOSOMAL ABERRATIONS IN ANAESTHETISTS
Mušák Ľ., Halašová E., Letková L., Osina O., Slováková P., Matáková T., Záborský T., Buchancová J.
Department of Medical Biology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Malá hora 4, 036 01 Martin, Slovakia
9:20 – 9:40 Evaluation of Chromosomal Damage and Polymorphism of selected DNA Repair Genes in Workers exposed to Chromium
Halašová E., Matáková T., Mušák Ľ., Poláková V., Letková L., Franeková M., Bukovská E., Vodička P.
Department of Medical Biology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia
9:40-9:55 BREAK
9:55 – 10:55
Session 6: Genotoxicity - continued
Chairpersons: E. Halašová & LudmilaVodičkova
9:55 – 10:55
9:55 – 10:15 DNA repair gene expressions in STYRENE-exposed individuals and in cancer patients
Vodickova L., Hanova M., Vaclavikova R., Stetina R., Hlavata I., Ehrlichová M., Kovar D.4, Soucek P., Vodicka P.
Natl. Inst. Publ. Health, Srobarova 48, Prague, Czech Rep.
10:15 – 10:35 Effect of exposure to cytostatics on chromosomal aberration and polymorphisms of DNA repair gene hOGG1
Letková L., Mušák L., Matáková T., Drgová A., Vodička P., Halašová E.
Department of Medical Biochemistry, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Mala Hora 4, 036 01 Martin, SR
10:35 – 10:55 Borneol supplementation in drinking water of rats protects primary hepatocytes against DNA-damaging oxidative stress
Horváthová E., Kozics K., Slameňová D.
Laboratory of Mutagenesis and Carcinogenesis, Cancer Research Institute, Slovak Academy of Sciences, Vlárska 7, 833 91 Bratislava, Slovak Republic
10:30-11:00 Poster instalation
10:30-17:00 Comertial exhibition
11:00– 17:00 Poster Session
Friday – May 20, 2011
8:30 – 11:40
Session 7: Methods & Models in Toxicology
Chairpersons: Marie Balíková & Tomáš Eckschlager
8:30 – 10:00
8:30 – 9:00 Drugs of abuse in hair. Forensic and social aspects
Balíková M.
Institute of Forensic Medicine and Toxicology, 1st Medical Faculty and General Teaching Hospital, Charles University in Prague, 121 08 Prague 2, Czech Republic
9:00 – 9:20 Chemoresitant cancer cell lines- models for study in vitro and in vivo
Eckschlager T., Hraběta J.,, Poljaková J., Stiborová, M.
Department of Pediatric Hematology and Oncology, 2nd Medical School, Charles University and University Hospital Motol, V Úvalu 84, 150 06 Prague 5, Czech Republic
9:20 – 9:40 Novel rat model of a stroke studied by menas in vivo MRI and MRS
Kašparová S. , Bačiak L., Kukurová I., Jozefovičová M., Kollárová R., Kebis A., Liptaj T.
Department of Analyt. Chem., Slovak University of Technology, Radlinského 9,Bratislava Slovakia
9:40 – 10:00 Interactions of polycyclic aromatic hydrocarbons and inflammatory mediators in a model of lung epithelial cells
Vondráček J., Umannová L., Topinka J., Milcová A., Krčmář P., Neča J., Kozubík A., Machala M.
Department of Cytokinetics, Institute of Biophysics AS CR, Královopolská 135, 612 65 Brno, Czech Republic
10:00-10:20 BREAK
Session 7: Methods & Models in Toxicology - continued
Chairpersons: Jan Vondráček & Jaroslav Mráz
10:20 – 11:40
10:20 – 10:40 DETERMINATION OF S-(HYDROXYPHENYLETHYL)CYSTEINE ADDUCTS IN GLOBIN AS BIOMARKERS OF EXPOSURE TO STYRENE
Mráz J., Hanzlíková I., Dušková Š., Frantík E., Stránský V., Linhart I.
National Institute of Public Health, Šrobárova 48, 100 42 Prague, Czech Republic
10:40 – 11:00 DETECTION OF BETA- KETO AMPHETAMINES IN ORIGINAL SAMPLES BY GC-MS, LC-ESI-MS-MS AND TLC METHODS
Marešová V., Chytil L., Hampl J., Zrcek F.
Institute of Forensic Medicine and Toxicology, First Faculty of Medicine, Charles University, Kateřinská 32, 128 01 Prague 2, Czech Republic
11:00 – 11:20 GENOTOXICITY AND MUTAGENICITY TESTS IN VITRO USED FOR SAFETY EVALUATION OF CHEMICALS AND FOR ENVIRONMENTAL HEALTH MONITORING
Očadlíková D., Vlková A., Šmíd J., Jírová D., Bendová H., Kejlová K.
National Institute of Public Health, Šrobárova 48, 100 42 Prague 10, Czech Republic
11:20 – 11:40 „Legal Highs“- Analytical Data on new Substances
Roman M.
Institute of Criminalistics Prague, Police of Czech Republic
11:40 Closing ceremony
Seznam posterů konference
P1 UTILISATION OF IODINE FROM DIFFERENT SOURCES BY SOWS AND THEIR PROGENY
Baňoch T. , Svoboda M , Fajt Z.
Clinic of Ruminant and Swine diseases, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, 612 00 Brno, Czech Republic
P2 Effects of sublethal exposure of European brown hares to pesticides on the course of tularemia
Bandouchova H., Pohanka M., Osickova J., Ondracek K., Kral J., Vitula F., Treml T., Pikula J.
Department of Veterinary Ecology and Environmental Protection, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
P3 Identification of rat cytochromes P450 activating and detoxicating carcinogenic aristolochic acid I
Bárta F., Levová K., Frei E., Schmeiser H.H., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, 128 40 Prague 2, Czech Republic
P4 Changes in biochemical and coagulation parameters during the usage of combined oral contraceptives in relation to genotype – pilot study
Bartošová L., Kolorz M., Wróblová K., Kostúrová I., Chýlková A., Horáková K., Parák T., Belan I.
Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
P5 Effect of platinum metals on duckweed
Beklova M., Soukupova I., Sochor J., Majzlik P., Strakova L., Adam V., Kizek R.
Department of Veterinary Ecology and Environmental Protection, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
P6 Ecotoxicity of Polycyclic Aromatic Hydrocarbons (PAHs) - evaluation of Bioassays with Earthworms
Beklová M., Vávrová M., Stoupalová M., Soukupová I., Štilárková E., Provalilová I.
Department of Veterinary Ecology and Environmental Protection, Faculty
of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
P7 Cardiac gap junctions are altered due to chronic and acute pathophysiological events.
Beňová T., Slezák J., Tribulová N.
Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic
P8 NUCLEAR THYROID HORMONE RECEPTOR SUBTYPES AND NUCLEAR RECEPTOR COREGULATORS IN MCF-7 CELLS AND HUMAN PRIMARY HEPATOCYTES: EFFECTS OF SELECTED ENDOCRINE-DISRUPTING CHEMICALS
Brtko J., Macejová D., Ondková S., Ficková M., Vrzal R., Dvořák Z.
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia,
P9 THE RAPID NEONATAL PROGRESSIVE BRAIN ATHROPHY – A CASE REPORT
Brucknerová I., Mach M., Dubovický M., Ujházy E.2
Ist Department of Paediatrics, School of Medicine, Comenius University, 833 40 Bratislava, Slovak Republic
P10The importance of isoprostanes.
Brucknerová I., Juránek I.:
Ist Department of Paediatrics, School of Medicine, Comenius University, 833 40 Bratislava, Slovak Republic
P11 NOVEL DERIVATIVES OF ACRIDINE: REACTIONS WITH THIOLS, BINDING TO DNA AND ANTICANCER POTENCIES
Čižeková L., Vantová Z., Záškvarová M., Krajňáková L., Othman S., Kožurková M., Sabolová D., Imrich J., Kristián P., Janovec L., Hamulaková S.,Vilková M., Paulíková H.
Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak Technical University, 81239 Bratislava, Slovakia
P12 Effects of cyanotoxins and lead on avian reproduction
Damkova V., Sedlackova J., Bandouchova H., Peckova L., Vitula F., Hilscherova K., Paskova V., Kral J., Osickova J., Ondracek K., Pohanka M., Pikula J.
Department of Veterinary Ecology and Environmental Protection, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
P13 EFFECT OF β-1,3/1,6-D-GLUCAN ON HEMATOLOGICAL, BIOCHEMICAL, IMMUNOLOGICAL AND HISTOPATHOLOGICAL INDICES OF COMMON CARP (CYPRINUS CARPIO L.) EXPOSED TO OXYTETRACYCLIN ANTIBIOTIC
Dobsikova R., Blahova J., Haluzova I., Macova S., Modra H., Novotna K., Svobodova Z.
University of Veterinary and Pharmaceutical Sciences Brno, Department of Veterinary Public Health and Toxicology, 612 42 Brno, the Czech Republic
P14 The role of residues Thr248, Tyr249 and Thr422 in the functions of human pregnane X receptor
Dořičáková A., Novotná A., Vrzal R., Pávek P., Dvořák Z.
Department of Cell Biology and Genetics, Faculty of Science, Palacky University in Olomouc, 783 71, Olomouc
P15 EFFECT of Imunoglukán® OR coenzyme Q10 on neutrophil oxidant production in rats with adjuvant arthritis
Drábiková K. , Jančinová V. , Nosáľ R., Mihalová D., Bauerová K.
Institute of Experimental Pharmacology and Toxicology Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic
P16 Comparison of effect of 3-nitrobenzanthrone on induction of biotransformation enzymes after intraperitoneal and intratracheal administration
Dračínská H., Mizerovská J., Arlt V.M., Frei E., Schmeiser H.H., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, 12840 Prague 2, Czech Republic
P17 PROLIFERATIVE EFFECTS OF BPA IN COMBINATION WITH E2 IN BREAST CARCINOMA CELLS.
Ficková M., Mlynarčíková A., Scsuková S., Brtko J., Havránek T.
Institute of Experimental Endocrinology, 833 06 Bratislava, Slovakia
P18 OPPOSITE EFFECT OF PYRIDOINDOLE ANTIOXIDANT ON LONG-TERM POTENTIATION IN CONTROL AND HYPOXIC RAT HIPPOCAMPAL SLICES
Gáspárová Z., Šnirc V., Štolc S.
Department of Neuropharmacology, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 841 04 Bratislava 4, Slovak Republic
P19 EFFECTS OF CLICK 500 SC (TERBUTHYLAZINE) ON PLASMA BIOCHEMICAL PARAMETERS OF COMMON CARP (CYPRINUS CARPIO)
Haluzová I., Blahová J., Modrá H., Maršálek P., Divišová L., Jarkovský J., Littnerová S., Svobodová Z.
Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno612 42 Brno, Czech Republic
P20 Expression profile of ABC transporter genes in breast carcinoma
Hlavac V., Vaclavikova R., Ehrlichova M., Hlavata I., Pecha V., Trnkova M., Gut I., Soucek P.
Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic
P21 TOXIC ENVIRONMENT AND OBESITY MENACE
Hlúbik P., Hlúbik J., Střítecká H.
Faculty of Military Health Sciences Hradec Králové, University of Defense, Czech
Republic
P22 Effect of melatonin on the antioxidative defense system in healthy and cadmium exposed rats
Hodková A., Kotyzová D., Eybl V.
Department of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University in Prague, 301 00 Pilsen, Czech Republic
P23 A Study of interactions of antitumour drug doxorubicin with DNA
Huska D., Zitka O., Sobrova P., Stiborova M., Eckschlager T., Adam V., Kizek R.
Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
P24 THE USE OF SELECTED CARRIER SOLVENTS IN EMBRYO TOXICITY TESTS ON DANIO RERIO
Chromcová L., Mácová S., Plhalová L., Svobodová Z.
Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, 612 42, Brno, Czech Republic
P25 Comparision of enzymatic activities of cytochromes P450 1A1, 1A2 and 3A4 expressed in prokaryotic and eukaryotic systems
Indra R., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, 128 40 Prague 2, Czech Republic
P26 Piceatannol, a natural analogue of resveratrol, inhibits oxidative burst of human neutrophils
Jančinová V., Perečko T., Drábiková K., Nosáľ R1, Sviteková K.
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic
P27 THE STUDY OF BIOCOMPATIBILITY AND CYTOTOXICITY OF COLADERM-GLUCAN MEmBRANE ON HUMAN CELL LINES.
Jantová S., Bakoš D., Matejov P., Danišovič Ľ., Melušová M.
Institute of Biochemistry, Nutrition and Helth Protection, Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37 Bratislava, Slovak Republic
P28 Structural insight into protein-protein interactions within the complex of cytochrome P450 1A1/2 and cytochrome b5
Jeřábek P., Martínek V.
Department of Biochemistry, Faculty of Science, Charles University, 128 40 Prague 2, Czech Republic
P29 Phototoxicity and mutagenicity hazard of pigments frequently used in cosmetics
Jírová D., Kejlová K., Kolářová H., Vlková A., Tománková K., Binder S., Dašková A., Očadlíková D., Bendová H., Jíra D., Šperlingová I., Dabrowská L.
National Institute of Public Health, 100 42 Prague 10, Czech Republic
P30 involvement of cerebral mitochondria in hypoxia-ischemia-induced brain injury in neonates. Postnanatal maturation of electron-transporting complexes in the brain of newborn rats
Juránek I., Kucharská J., Sumbalová Z.¨
Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences;
P31 Examination of extracts from iced-teas and flavored mineral waters on CYP1A1. expression in human hepatocytes and cell lines
Kameníčková A., Vrzal R., Dvořák Z.
Department of Cell Biology and Genetics, Faculty of Science, Palacky University in Olomouc, 783 71, Olomouc
P32 The reactivating efficacy of a novel bispyridinium oxime K203 in rats poisoned with nerve agents – a comparison with commonly used oximes
Kassa J., Zdarova Karasova J., Kuca K, Musilek K, Sepsova V. Bajgar J.
Department of Toxicology, Faculty of Military Health Sciences, University of Defense,500 01 Hradec Kralove, Czech Republic
P33 Introducing the Photochem® device into the biochemical analysis – the measurement of the antioxidant capacity
Kopřiva V., Nekvapil T., Hostovský M., Smutná M., Malota L.
Department of Biochemistry, Chemistry and Biophysics, University of Veterinary and PharmaceuticalSciences Brno, 612 42 Brno, Czechrepublic
P34 The effect of cytochrome b5 on ellipticine oxidation mediated by cytochrome P450 1A1
Kotrbová V., Mrázová B., Martínek V., Frei E., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, 128 40 Prague 2,Czech Republic
P35 THE EFFECT OF OLIVE OIL PHENOLICS – HYDROXYTYROSOL AND OLEUROPEIN ON ANTIOXIDANT DEFENCE STATUS IN ACUTE ARSENIC EXPOSED RATS
Kotyzová D., Hodková A., Eybl V.
Department of Pharmacology & Toxicology, Faculty of Medicine, Charles University,301 66 Pilsen, Czech Republic
P36 PROTECTIVE POTENTIAL OF SALVIA OFFICINALIS AND THYMUS VULGARIS EXTRACTS IN HUMAN HEPG2 CELL LINE
Kozics K., Horváthová E.
Laboratory of Mutagenesis and Carcinogenesis, Cancer Research Institute, Slovak
Academy of Sciences, 833 91 Bratislava, Slovak Republic
P37 Biomonitoring of occupational exposure to styrene in a plastics lamination plant
Krajčovičová Z., Poláková M., Meluš V., Cích B., Slobodníková J.
Department of Laboratory Medicine, Faculty of Healthcare, Alexander Dubček
University of Trenčín, 911 01 Trenčín, Slovak Republic
P38 NOVEL DNA BINDING LIGANDS WITH ACETYLCHOLINESTERASE INHIBITORY POTENCY
Krajňáková L., Vantová Z., Čižeková L., Bačová Z., Bakeš J., Hamuľaková S., Kožurková M., Sabolová D., Plšíková J., Imrich J., Kristián P., Danihel I., Drajna L., Paulíková H.
Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak Technical University, 81239 Bratislava, Slovakia
P39 PROPORTION OF MERCURY CONTENT BETWEEN MUSCLE AND LIVER OF FISH
Kružíková K. , Kenšová R. , Gajdová L., Svobodová Z.
Department of veterinary public health and toxicology, Faculty of veterinary
hygiene and ecology, Veterinary and Pharmaceutical sciences Brno, 612 42 Brno
P40 The in vitro evaluation of the cholinesterase reactivators for preparation of scavenger-based antidotes against organophosphorus poisoning
Krenkova Z., Musilek K., Kuca K., Jun D.
Centre of Advanced Studies and 2Department of Toxicology Faculty of Military Health Sciences, Hradec Králové, 50001, Czech Republic
P41 Monitoring of carbon nanoparticles toxicity on plant tissue culture
Krystofova O., Vyslouzil L., Elias M., Sochor J., Adam V., Kudrle V., Hubalek J., Trnkova L., Kizek R.
Department of Chemistry and Biochemistry, Faculty of Agronomy Mendel University in Brno, 613 00 Brno, Czech Republic
P42 Influence of probiotic strain Escherichia coli Nissle 1917 administration on absorption kinetics of 5-aminosalicylic acid in rat
Kuneš M., Květina J., Kholová D., Bureš J., Tláskalová-Hogenová H.
Institute of Experimental Biopharmaceutics, Joint Research Centre of Czech Academy of Sciences and PRO.MED.CS Praha a.s., Hradec Králové, Czech Republic
P43 Testing novel pyridoindole derivatives on selenite-induced In vitro model of cataractogenesis
Kyselova Z. , Weismann P.2, Drimal J., Stefek M.
Laboratory of Cell Cultures, Institute of Experimental Pharmacology and
Toxicology, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic
P44 Metabolism of aristolochic acid I by cytochromes P450
Levová K., Bárta F., Frei E., Arlt V.M., Phillips D.H., Schmeiser H.H., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, Albertov
2030, 128 40 Prague 2, Czech Republic
P45 Effect of pinosylvin and pterostilbene on oxidative burst and release of enzymes from human neutrophils in vitro
Mačičková T., Nosáľ R., Harmatha J., Sviteková K., Pečivová J.
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of
Sciences,841 04 Bratislava, Slovak Republic
P46 Behavioral models used for screening of psychopharmacological effect of potential anxiolytic and antidepressive drugs
Mach M., Ujházy E., Kovačovský P., Navarová J., Brucknerová I., Dubovický M.
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of
Sciences,Bratislava, , 841 04 Bratislava, Slovakia
P47 Metallothionein based biosensor for determination of heavy metals
Majzlik P., Hubalek J., Trnkova L., Zehnalek J., Adam V., Kizek R.
Mendel University in Brno, Department of Chemistry and Biochemistry, Faculty of
Agronomy, 613 00 Brno, Czech Republic
P48 A study of Changes in metallothionein level in fishes treated with aluminium(III) ions
Majzlik P., Wauer G., Zitka O., Svobodova Z., Beklova M., Adam V., Kizek R.
Mendel University in Brno, Department of Chemistry and Biochemistry, Faculty of
Agronomy, 613 00 Brno, Czech Republic
P49 Gas chromatograPHy - ion trap tandem mass spectrometry determination of bromadiolonE in tissues
Maršálek P., Zelníčková L., Modrá H., Svobodová Z.
Department Veterinary Public Health and Toxicology, Faculty of Veterinary hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic.
P50 INHIBITORS OF CYTOCHROMES P450 AND THEIR EFFECT ON PEROXIDASE ACTIVITY
Martínková M., Martínek V., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, 128 40 Prague 2, Czech Republic
P51 Expression of biotransformation enzymes in the liver and in the intestine of male rat after application of the probiotic Lactobacillus casei
Matušková Z., Tunková A., Anzenbacherová E., Zachařová A., Tlaskalová‑Hogenová H.,
Zídek Z , Anzenbacher P.
Department of Pharmacology and Department of Medical Chemistry and
Biochemistry,Faculty of Medicine and Dentistry, Palacký University Olomouc,775
15 Olomouc, Czech Republic
P52 4-ANILINOQUINAZOLINES – NEW POTENTIAL SENSITIZERS FOR PHOTODYNAMIC THERAPY
Melušová M., Barbieriková Z., Jantová S., Brezová V.
Institute of Biochemistry, Nutrition and Health Protection, Faculty of Chemical
and Food Technology, Slovak University of Technology, SK-812 37 Bratislava,
SlovakRepublic
P53 Differences between normal and tumor pulmonary cells in the uptake and toxicity of Fe3O4 nanoparticles
Mesárošová M., Závišová V, Timko M., Ursínyová M., Hušeková Z., Gábelová A.
Cancer Research Institute, SAS, Bratislava, Slovakia
P54 Metabolism of benzo[a]pyrene by cytochromes P450
Moserová M., Frei E., Arlt V.M., Phillips D.H., Schmeiser H.H., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, 128 40
Prague 2, Czech Republic
P55 Construction of stable cell line over-expressing hepatocyte nuclear factor HNF4-α
Novotná A., Dořičáková A., Vrzal R., Pávek.P., Dvořák Z.
Department of Cell Biology and Genetics, Faculty of Science, Palacky University in Olomouc, 783 71, Olomouc
P56 THE EFFECT OF PERORAL ADMINISTRATION OF TOXIC CYANOBACTERIA ON LABORATORY RATS (RATTUS NORVEGICUS VAR. ALBA)
Palíková M., Kopp R., Ondráčková P., Mareš J., Adamovský O., Kratochvílová P., Bláha L.
Department of Veterinary Ecology and Environmental Protection, Faculty of
Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical
Science Brno, 612 42 Brno, Czech Republic
P57 NUTRIENT COMPOSITION OF COMBAT RATION IN THE ARMY OF THE CZECH REPUBLIC
Pavlík V., Fajfrová J., Husárová M., Hlúbik P., Drahokoupilová E.
Department of Military Hygiene, Faculty of Military Health Sciences, University
of Defence, 50001, Hradec Králové, Czech Republic
P58 Possible beneficial effects of arbutin on attenuation of inflammation related diseases
Pečivová J., Nosáľ R., Sviteková K., Mačičková T.
Institute of Experimental Pharmacology and Toxicology SASc, 841 04 Bratislava, Slovak Republic
P59 Preliminary evaluation of the effects of H4-RECEPTOR ligands on reactive oxygen species production in human neutrophils
Perečko T., Drábiková K., Nosáľ R., Jančinová V.
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic
P60 Cytotoxicity of lipophilic rutin derivatives on cancer cells
Píšová P., Viskupičová J. , Jantová S.
Institute of Biochemistry, Nutrition and Health Protection, Faculty of Chemical and Food
Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia
P61 Effects of subchronic exposure of atrazine on Danio reri
Plhalová L., Haluzová I., Mácová S., Doleželová P., Maršálek P., Škorič M., Svobodová Z., Pištěková V., Bedáňová I., Modrá H., Voslářová E.
Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology
P62 Study of neuroblastoma cells under hypoxia
Poljaková J. , Hraběta J., Eckschlager T., Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, 128 40
Prague 2,Czech Republic
P63 COMPARISON OF ACUTE TOXICITY OF KETOPROFEN TO JUVENILE AND EMBRYONIC STAGES OF DANIO RERIO
Prášková E., Voslářová E., Široká Z., Mácová S., Plhalová L., Bedáňová I., Maršálek P., Pištěková V., Svobodová Z.
Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
P64 ACRIDINE ORANGE DYE: THE TOOL TO ASSESS THE PURITY OF ISOLATED PRIMARY MICROGLIA
Račková L. , Knezl V., Blaško M., Bezek Š.
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences 841 04 Bratislav, Slovak Republic
P65 UVA radiation increased the cytotoxicity and genotoxicity of N-heterocyclic aromatic hydrocarbons
Regendová E., Gábelová A.
Cancer Research Institute, SAS, Bratislava, Slovakia
P66 A review: Pyrethroids influence on fish.
Richterová Z., Hostovský M., Svobodová Z.2
Faculty of Fisheries and Protection of Waters, University of South Bohemia in
České Budějovice, Vodňany, Czech Republic
P67 EFFECTS OF NEUROTOXIN–ANATOXIN-A ON COMMON CARP (CYPRINUS CARPIO L.) INNATE IMMUNE CELLS IN VITRO
Rymuszka A., Sierosławska A.
Department of Physiology and Ecotoxicology, Institute of Biotechnology, The John Paul II Catholic University of Lublin, 20 – 950 Lublin, Poland
P68 REPRODUCTIVE PARAMETERS IN FEMALE wISTAR RATS FOLLOWING NEONATAL EXPOSURE TO POLYMERIC NANOPARTICLE peg-b-pla
Scsuková S. , Rollerová E., Jurčovičová J., Mlynarčíková A., Kovrižnych J., Zeljenková D.
Institute of Experimental Endocrinology, Slovak Academy of Sciences, 833 06
Bratislava,Slovak Republic
P69 INHIBITORY EFFECT OF REACTIVATORS ON ACETYLCHOLINESTERASE: IN VITRO TESTING
Šepsová V.1, Karasova J.Z
Department of Toxicology, Faculty of Military Health Sciences, University of Defence, 500 01 Hradec Kralove, Czech Republic
P70 Veterinary toxicology database vettox – new informatory service for both general public and veterinary doctors
Široká Z., Svobodová Z., Modrá H., Večerek V.
Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
P71 Effect of organic and inorganic form of selenium on Selected biochemical parameters of rat
Sochor J., Hejnova N., Sobrova P., Mares P., Zeman L., Beklova M., Adam V., Kizek R.
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel
University in Brno, 613 00 Brno,Czech Republic
P72 Effect of probiotic Escherichia coli Nissle 1917 components on transport of 5-aminosalicylic acid across Caco-2 cell monolayers
Štětinová V., Smetanová L., Kholová D., Květina J., Svoboda Z., Zídek Z., Tlaskalová-Hogenová H.
Institute of Experimental Biopharmaceutics, Joint Research Center of PRO.MED.CS Praha a.s. and the Academy of Sciences of the Czech Republic, Hradec Kralove, Czech Republic
P73 Different effects of sulphotransferases and N-acetyltranferases on activation of aristolochic acid I and II with NADPH:quinone oxidoreductase
Stiborová M., Martínek V., Kubíčková B., Hudeček J., Frei E., Arlt V.M., Phillips D.H., Schmeiser H.H.
Department of Biochemistry, Faculty of Science, Charles University, 128 40 Prague 2, Czech Republic
P74 SERUM LEVEL OF SELECTED COMPONENTS OF ANTIOXIDANTS SYSTEM
Střítecká H., Hlúbik P.
Faculty of Military Health Science, Hradec Kralove, Czech Republic
P75 OCCURRENCE AND EFFECTS OF ALKYLPHENOLS ON THE AQUATIC ECOSYSTEM
Schandlová L., Blahová J., Svobodová Z.
Department of Veterinary Public Health and Toxicology, Faculty of Veterinary
Hygiene and Ecology, University of Veterinary and Pharmaceutical Science
Brno, 612 42 Brno,Czech Republic
P76 EFFECT OF MODEL FLAVONILIGNAN ON METABOLISM OF WARFARIN IN RATS IN VITRO
Tunková A., Anzenbacherová E., Jančová P., Křen V., Anzenbacher P.
Department of Pharmacology and Department of Medical Chemistry and
Biochemistry,Faculty of Medicine and Dentistry, Palacký University, 775 15
Olomouc, Czech Republic
P77 eLECTROCHEMICAL Study of the interactions of SANgUINARINE and ITS metabolite with SUPERCOILED DNA
Vacek J., Vrublová E., Kubala M., Janovská M., Fojta M., Šimková E.,
Stýskala J., Skopalová J., Hrbáč J., Ulrichová J.
Faculty of Medicine and Dentistry, Palacký University, 775 15 Olomouc, Czech Republic
P78 Isolation and partial characterization of extracellular NADPH-dependent phenol hydroxylase oxidizing phenol to catechol in Comamonas testosteroni
Vilímková L., Turek M., Kremláčková V., Páca J. Jr, Halecký M., Páca J.,
Stiborová M.
Department of Biochemistry, Faculty of Science, Charles University, 128 40
Prague 2, Czech Republic
P79 EFFECT OF NOVEL QUERCETIN DERIVATIVES ON SARCOPLASMICRETICULUM Ca2+-ATPase (I)
Viskupičová J., Žižková P., Držík F., Veverka M., Horáková Ľ.Institute of Experimental Pharmacology and Toxicology of Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, Slovakia
P80 EFFECT OF MACLEAYA CORDATA ALKALOIDS ON NRF2 SIGNALING PATHWAY
Vrublová E., Vrba J., Ulrichová J.
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and
Dentistry, Palacky University775 15 Olomouc, Czech Republic
P81 The effect of sibutramine on the expression of cytochromes P450 regulated by AhR and PXR receptors
Vrzal R., Dvořák Z.
Department of Cell Biology and Genetics, Faculty of Science, Palacky University
in Olomouc, 783 71, Olomouc
P82 Cytotoxicity of neutral and acid forms of carboxymethyl cellulose, and comparison with other modified types of cellulose in vitro
Závalová V., Babula P., Suchý P., Parák T., Hošek J. Kollár P.
Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
P83 Structural Changes of AChE Reactivators Play an Important Role in Distribution After in vivo Application
Zemek F., Zdarova Karasova J., Pohanka M., Kassa J., Musílek K., Kuca K.
Department of Toxicology and Centre of Advances Studies, Faculty of Health Sciences, University of Defence, 500 01 Hradec Kralove, Czech Republic
P84 Monitoring of phytochelatin synthase activity in presence of cadmium(II) ions
Zitka O., Krystofova O., Adam V., Zehnálek J., Kizek R.
Department of Chemistry and Biochemistry, Mendel University, 61300 Brno,
Czech Republic.
P85 Assessment of oxidative stress in plants treated by fluoranthen
Zitka O., Beklova M., Krystofova O., Sochor J., Adam V., Havel L., Kizek R.
Department of Chemistry and Biochemistry and Department of Plant Botany,
Mendel University, 61300 Brno, Czech Republic.
P86 RETICULUM Ca2+-ATPase (II)
Žižková P., Viskupičová J. , Veverka M. , Horáková Ľ.
Institute of Experimental Pharmacology and Toxicology, SAS, Bratislava,
Slovakia