The Whi2p-Psr1p/Psr2p complex regulates interference competition and expansion of cells with competitive advantage in yeast colonies

Maršíková J., Pavlíčková M., Wilkinson D., Váchová L., Hlaváček O., Hatáková L., Palková Z. (2020) PNAS first published June 15, 2020

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Cell distribution within yeast colonies and colony biofilms: How structure develops

Plocek V., Váchová L., Šťovíček V., Palková Z. (2020) International Journal of Molecular Sciences 21: 3873; doi:10.3390/ijms2111387

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Glucose, Cyc8p and Tup1p regulate biofilm formation and dispersal in wild Saccharomyces cerevisiae

Van Nguyen P., Plocek V., Váchová L., Palková Z. (2020) npj Biofilms and Microbiomes 6:7;

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Diverse roles of Tup1p and Cyc8p transcription regulators in the development of distinct types of yeast populations

Vachova L., Palkova Z. (2019) Current Genetics 65(1): 147-151

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Long non-coding RNAs in yeast cells and differentiated subpopulations of yeast colonies and biofilms

Wilkinson D., Váchová L., Hlaváček O., Maršíková J., Gilfillan G.D., Palková Z. (2018) Oxidative Medicine and Cellular Longevity, Volume 2018, Article ID 4950591, 12 pages 

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Transcriptome remodeling of differentiated cells during chronological ageing of yeast colonies: New insights into metabolic differentiation

Wilkinson D., Maršíková J., Hlaváček O., Gilfillan GD., Ježková E., Aaløkken R., Váchová L., Palková Z. (2018)  Oxidative Medicine and Cellular Longevity, Volume 2018, Article ID 4932905

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How structured yeast multicellular communities live, age and die?

Vachova L., Palkova Z. (2018) FEMS Yeast Research 18, 2018, foy033, 1-9

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An optimized FAIRE procedure for low cell numbers in yeast

Segorbe, D., Wilkinson D., Mizeranschi A., Hughes T., Aaløkken R., Vachova L., Palkova Z., D. Gilfillan G.D. (2018) Yeast 2018: 1-6 doi: 10.1002/yea.3316

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Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Aouacheria A, Cunningham, KW., Hardwick, JM., Palková, Z., Powers, T., Severin, FF., Váchová, L. (2018), Science 360 (6395): eaar6910, DOI: 10.1126/science.aar6910, Document Type: Editorial Material

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Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity

Van Nguyen P., Hlavacek O., Marsikova J., Vachova L., Palkova Z. (2018) PLoS genetics

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Diverse roles of Tup1p and Cyc8p transcription regulators in the development of distinct types of yeast populations

Vachova L., Palkova Z. (2018) Current Genetics, DOI 10.1007/s00294-018-0883-z

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Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis

Hovsepian J., Defenouillère Q., Albanèse V., Váchová L., Garcia C., Palková Z., Léon S. (2017)  J. Cell Biol. 216(6): 1811-1831

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Metabolic differentiation of surface and invasive cells of yeast colony biofilms revealed by gene expression profiling

Maršíková J., Wilkinson D., Hlaváček O., Gilfillan G., Mizeranschi A., Hughes T., Begany M., Rešetárová S., Váchová L., Palková Z. (2017) BMC Genomics (2017) 18:814, DOI 10.1186/s12864-017-4214-4

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Yeast Tok1p channel is a major contributor to membrane potential maintenance under chemical stress

Zahumensky J. , Jancikova I., Drietomska A., Svenkrtova A., Hlavacek O., Hendrych T., Plasek J., Sigler K., Gaskova D. (2017) . Biochimica et Biophysica Acta-Biomembranes 1859 (10 ): 1974-1985

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Yeast cell differentiation: Lessons from pathogenic and non-pathogenic yeasts

Palkova Z, Vachova L (2016) SeminCell Dev Biol. 57: 110-9


Cellular localization of Sun4p and its interaction with proteins in the yeast birth scar

Kuznetsov E, Vachova L, Palkova Z. (2016) Cell Cycle 15: 1898-907

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Divergent branches of mitochondrial signaling regulate specific genes and the viability of specialized cell types of differentiated yeast colonies

Podholova K, Plocek V, Resetarova S, Kucerova H, Hlavacek O, Vachova L, Palkova Z (2016)   Oncotarget 7: 15299-314

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Longevity of U cells of differentiated yeast colonies grown on respiratory medium depends on active glycolysis

Cap M, Vachova L, Palkova Z, (2015)  Cell Cycle. 14: 3488-97

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Aging and differentiation in yeast populations: Elders with different properties and functions

Palkova, Z, Wilkinson, D, Vachova, L (2014) FEMS Yeast Res 14: 96-108

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Global changes in gene expression associated with phenotypic switching of wild yeast

Stovicek V, Vachova L, Begany M, Wilkinson D, Palkova Z (2014) BMC Genomics 15: Art. No. 136, DOI: 10.1186/1471-2164-15-136

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SUN Family Proteins Sun4p, Uth1p and Sim1p Are Secreted from Saccharomyces cerevisiae and Produced Dependently on Oxygen Level

Kuznetsov E, Kucerova H, Vachova L, Palkova Z (2013) PLoS One 8: e73882. doi: 10.1371/journal.pone.0073882

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The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies

Paiva S, Strachotová D, Kucerova H, Hlavacek O, Mota S, Casal M, Palkova Z, Vachova L (2013) Biochem J454: 551-558


Rapidly Developing Yeast Microcolonies Differentiate in a Similar Way to Aging Giant Colonies

Vachova, L, Hatakova, L, Cap, M, Pokorna, M, Palkova, Z (2013)  Oxidative Med Cell Longev, Art. No.: UNSP 102485, doi:  10.1155/2013/102485

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The bZIP transcription factor Rca1p is a central regulator of a novel CO2 sensing pathway in yeast

Cottier, F Raymond, M, Kurzai, O, Bolstad, M, Leewattanapasuk, W, Jiménez-López, C , Lorenz, MC, Sanglard, D, Váchova, L, Pavelka, N,  Palkova, Z, Mühlschlegel, FA (2012). PLOS Pathogen 8: e1002485,   DOI: 10.1371/journal.ppat.1002485

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Cell differentiation within a yeast colony: Metabolic and regulatory parallels with a tumor-affected organism

Cap, M., Stepanek, L, Harant, K, Vachova,L, Palkova Z. (2012) Mol Cell  46: 436-448

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Reactive oxygen species in the signaling and adaptation of multicellular microbial communities

Cap, M, Vachova, L, Palkova, Z (2012) Oxidative Med Cell Longev, Article ID 976753, 13 pages, doi:10.1155/2012/976753

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Communication and differentiation in the development of yeast colonies

Palkova, Z., Vachova, L (2012), In: Biocommunication in Fungi, Edited by Guenther Witzany, Springer 2012, pp 141-154

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In vivo determination of organellar pH using a universal wavelength-based confocal microscopy approach

Pineda-Rodo, A, Vachova, L, Palkova, Z (2012) PLOS One 7: e33229. doi:10.1371/journal.pone. 0033229

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Ato protein interactions in yeast plasma membrane revealed by fluorescence lifetime imaging (FLIM)

Strachotova, D, Holoubek, A, Kucerova, H, Benda, A, Humpolickova, J, Vachova, L, Palkova, Z (2012)  BBA-Biomembranes1818: 2126-2134

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Yeast Colonies: A Model for Studies of Aging, Environmental Adaptation, and Longevity

Vachova, L, Cap, M., Palkova, Z. (2012)  Oxidative Med Cell Longev Art. No: 601836   DOI: 10.1155/2012/601836

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Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies

Vachova L, Stovicek V, Hlavacek O, Chernyavskiy O, Stepanek L, Kubinova L, Palkova Z. (2011)  J Cell Biol194: 679-87

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Aging and longevity of yeast colony populations: metabolic adaptation and differentiation

Vachova L, Palkova Z (2011) . Biochem Soc Trans39: 1471-5


General factors important for the formation of structured biofilm-like yeast colonies

Stovicek V, Vachova L, Kuthan M, Palkova Z. (2010)  Fungal Genet Biol47: 1012-22


How to survive within a yeast colony: Change metabolism or cope with stress?

Cap M, Vachova L, Palkova Z. (2010) Commun Integr Biol 3: 198-200

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Role of distinct dimorphic transitions in territory colonizing and formation of yeast colony architecture

Vopalenska I, Stovicek V, Janderova B, Vachova L, Palkova Z (2010)  Environ Microbiol 12: 264-77


Yeast colony survival depends on metabolic adaptation and cell differentiation rather than on stress defense

Cap M, Vachova L, Palkova Z. (2009)  J Biol Chem28432572-81


Architecture of developing multicellular yeast colony: spatio-temporal expression of Ato1p ammonium exporter

Vachova L, Chernyavskiy O, Strachotová D, Bianchini P, Burdiková Z, Ferciková I, Kubinova L, Palkova Z (2009)  Environ Microbiol11: 1866-1877

PubMedFaculty of 1000 Biology 

Synchronous plasma membrane electrochemical potential oscillations during yeast colony development and aging

Palkova Z, Vachova L, Gaskova D, Kucerova H. (2009)  Mol Membr Biol26: 228-35


Putative role for ABC multidrug exporters in yeast quorum sensing

Hlavacek O, Kucerova H, Harant K, Palková Z, Vachová L. (2009) . FEBS Lett583: 1107-13


Metabolic diversification of cells during the development of yeast colonies

Vachova, L., Kucerova, H., Devaux,F., Ulehlova,M., Palkova,Z. (2009)  Environ. Microbiol11: 494-504


Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localization in patches

Ricicova, M., Kucerova, H, Vachova, L., Palkova, Z. (2007) BBA-Biomembranes,  1768: 1170-8


Caspases in yeast apoptosis-like death: Facts and artefacts

Váchová, L., Palková, Z. (2007)  FEMS Yeast Res. 7: 12-21


Life within a community, benefit to yeast long-term survival

Palková, Z., Váchová, L. (2006)  FEMS Microbiol. Rev. 30: 806-824


The morphology of Saccharomyces cerevisiae colonies is affected by cell adhesion and the budding pattern

Vopalenska I, Hulkova M, Janderova B, Palkova Z. (2005)  Res Microbiol.  156: 921-31


Physiological regulation of yeast cell death in multicellular colonies triggered by ammonia

Vachova,L., Palkova,Z. (2005) J.Cell Biol.169, 711-717

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Sok2p transcription factor is involved in adaptive program relevant for long-term survival of Saccharomyces cerevisiae colonies

Vachova L, Devaux F, Kucerova H, Ricicova M, Jacq C, Palkova Z. (2004)  J Biol Chem. 279: 379773-81

PubMed Full text

Multicellular microorganisms: Laboratory versus nature

Palková, Z. (2004) EMBO Rep. 5: 470-476,  review

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Ammonia signalling in yeast colony formation

Palková, Z. , Vachova L. (2003)  Int. Rev. Cytol. 225: 229-272,  review

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Domestication of wild Saccharomyces cerevisiae is accompanied by changes in gene expression and colony morphology

Kuthan,M., Devaux, F., Janderová, B., Slaninová, I, Jacq, C., Palková, Z. (2003)   .  Mol. Microbiol.47: 745-754


Ammonia pulses and metabolic oscillations guide yeast colony development

Palkova,Z, Devaux,F., Ricicova, M, Minarikova,L., LeCrom,S., Jacq,C. (2002) Mol. Biol. Cell., 13: 3901-3914

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Amino acids control ammonia pulses in yeast colonies

Zikanova,B., Kuthan M, Ricicova, M, Forstova J, Palkova Z. (2002)  Biochem. Biophys. Res. Commun294: 962-967


Differentiated Gene Expression in Cells within Yeast Colonies

Minarikova L, Kuthan M, Ricicova, M, Forstova J, Palkova Z. (2001)  Exp. Cell Res271: 296-304.


Yeast colonies synchronise their growth and development

Palková, Z. and Forstová, J. (2000).  J.Cell Sci. 113, 1923-1928.


Ammonia mediates communication between yeast colonies

Palková, Z., Janderová, B., Gabriel, J., Zikánová, B., Pospísek, M., Forstová, J. (1997) , Nature 390: 532-536.