A new international project, titled Exploiting Molecular Mechanisms of Natural Killer Cell Recognition for Antitumor Therapy, has been launched with funding from the Ministry of Education, Youth and Sports of the Czech Republic through the INTER-ACTION program. The collaboration between Ondřej Vaněk’s team and Dr. Grzegorz Piszczek‘s laboratory at the National Heart, Lung, and Blood […]
A new project, called Structural Immunology of NK Cell Recognition: From Tumour Evasion to Its Eradication, led by Ondřej Vaněk, has been awarded funding by the Czech Science Foundation (GA ČR). Running from 2025 to 2027 (Grant No. 25-18490S), this study aims to advance our understanding of NK cell-mediated immune responses at the structural level. […]
In 2024, several Master’s and Bachelor’s theses from our laboratory were successfully defended. Notably, Kristýna Pazderová received a nomination for the Rector’s Award for her Master’s thesis on the structural biochemistry of NKp80, an activation receptor of human lymphocytes. Other defended Master’s theses include Yurii Dubanych‘s research on galectin-3 interaction with NKp30, Gabriela Chytrá‘s work […]
Our research has been featured on the front cover of the JCI Insight journal (Volume 9, Issue 18, published on 24th September 2024). The image highlights our work on IL-2 immunocytokines, showcasing their potential for targeted immune modulation. This recognition underscores the significance of our findings in cytokine engineering and immune therapy. This study is […]
Postdoctoral researcher Ondřej Skořepa and PhD student Celeste Abreu from our laboratory participated in the 48th FEBS Congress, held in Milan, Italy, from 29 June to 3 July 2024. This prestigious event, hosted by the Italian Society of Biochemistry and Molecular Biology (SIB), brought together scientists from around the world to discuss the latest advancements […]
On 30th May 2024, our research group leader Ondřej Vaněk presented at the 2nd Immunotherapy Day at ÚHKT, Prague, a conference dedicated to advancements in cellular immunotherapy. The event brought together researchers from the Czech Republic and Finland to exchange insights on the development, production, and clinical application of immune cell therapies. Ondřej Vaněk’s presentation, […]
Two of our promising young students, Celeste Abreu and Yuri Dubanych, have recently attended the Instruct-ERIC Biennial Structural Biology Conference in Cascais, Lisbon. Held on 23–24 May 2024, the event brought together experts from across Europe to discuss the latest advancements in biomolecular research. Celeste Abreu presented her research on “Isotope labelling of Siglec-7 in […]
From 21–23 March 2024, the annual XX. Discussions in Structural Molecular Biology and the 7th User Meeting of CIISB took place at Nový Zámek in Nové Hrady, South Bohemia. The event brought together experts in molecular biology to discuss the latest advancements in the field. Here, our research group leader Ondřej Vaněk delivered a presentation […]
The Laboratory of Structural Biochemistry of Immune Recognition wishes you a prosperous and happy new year! Similarly to high-fidelity DNA polymerases such as Pfu, may we all also have those highly desirable properties! 😉