Curriculum vitae – MSc. Celeste Abreu

Skořepa O., Pažický S., Kalousková B., Bláha J., Abreu C., Ječmen T., Rosůlek M., Fish A., Sedivy A., Harlos K., Dohnálek J., Skálová T., Vaněk O. (2020): Natural killer cell activation receptor NKp30 oligomerization depends on its N-glycosylation. Cancers 12, 1998. IF 6.639 DOI: 10.3390/cancers12071998

López-Méndez B., Baron B., Brautigam C. A., Jowitt T. A., Knauer S. H., Uebel S., Williams M. A., Sedivy A., Abian O., Abreu C., Adamczyk M., Bal W., Berger S., Buell A. K., Carolis C., Daviter T., Fish A., Garcia-Alai M., Guenther C., Hamacek J., Holková J., Houser J., Johnson C., Kelly S., Leech A., Mas C., Matulis D., McLaughlin S. H., Montserret R., Nasreddine R., Nehmé R., Nguyen Q., Ortega-Alarcón D., Perez K., Pirc K., Piszczek G., Podobnik M., Rodrigo N., Rokov-Plavec J., Schaefer S., Sharpe T., Southall J., Staunton D., Tavares P., Vaněk O., Weyand M., Wu D. (2021): Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study. Eur Biophys J 50, 411-427. IF 1.733 DOI: 10.1016/10.1007/s00249-021-01532-6

Kalousková B., Skořepa O., Cmunt D., Abreu C., Krejčová K., Bláha J., Sieglová I., Král V., Fábry M., Pola R., Pechar M., Vaněk O. (2021): Tumor marker B7-H6 bound to the coiled coil peptide-polymer conjugate enables targeted therapy by activating human natural killer cells. Biomedicines 9, 1597. IF 6.081 DOI: 10.3390/biomedicines9111597

Vaněk O., Kalousková B., Abreu C., Nejadebrahim S., Skořepa O. (2022): Natural killer cell-based strategies for immunotherapy of cancer. Adv Protein Chem Struct Biol, in press. IF 3.507 DOI: 10.1016/bs.apcsb.2022.02.001

Remans K., Lebendiker M., Abreu C., Maffei M., Sellathurai S., May M. M., Vaněk O., de Marco A. (2022): Protein purification strategies must consider downstream applications and individual biological characteristics.Microb Cell Fact 21, 52. IF 6.352 DOI: 10.1186/s12934-022-01778-5

Bláha J., Skálová T., Kalousková B., Skořepa O., Cmunt D., Grobárová V., Pazicky S., Poláchová E., Abreu C., Stránský J., Kovaľ T., Dušková J., Zhao Y., Harlos K., Hašek J., Dohnálek J., Vaněk O. (2022): Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse.Nat Commun 13, 5022. IF 17.694 DOI: 10.1038/s41467-022-32577-6

Di Carluccio C., Milanesi F., Civera M., Abreu C., Sattin S., Francesconi O., Molinaro A., Vaněk O., Marchetti R., Silipo A. (2023): Tumor carbohydrate associated antigen analogs as potential binders for Siglec-7. Eur J Org Chem 26, e202300644. IF 3.261, DOI: 10.1002/ejoc.202300644

Helmholtz Training Course on Integrative Structural Biology, CSSB, Hamburg, Germany (2018) – “The role of glycosylation in the interaction between human NK cell receptor CD69 and its proposed ligand Galectin-1” – Poster

XVI. Discussions in Structural Molecular Biology, CSSB, Nové Hrady, Czech Republic (2019) “Study of N-glycan moiety dependency in the interaction of human early activation marker CD69 with its proposed ligand galectin-1” – Poster

XX. Interdisciplinary Meeting of Young Life Scientists, CSSB, Virtual (2021) “Selection of a nanobody against NKp30 for generation of fusion immunoligands aimed at activation of NK cell cytotoxicity against tumour cells” – Poster

45th FEBS Congress, Virtual (2021) “A biophysical approach to the characterization of the glycosylation-dependent interaction of human NK cell receptors and Galectin-1” – Poster

FEBS Advanced Methods in Macromolecular Crystallization IX. České Budějovice, Czech Republic (2021) “A biophysical approach to the characterization of the glycosylation-dependent interaction of NK cell receptor CD69 and Galectin-1” – Poster

XXVI. Annual Congress of Czech and Slovak Societies for Biochemistry and Molecular Biology, ČSBMB, České Budějovice, Czech Republic (2021) “Biophysical analysis of the structurally conserved interaction between Galectin-1 and C-type lectin-like receptors of NK cells” – Poster

INNOGLY “Young Glyco-Scientists on Stage”, Virtual (2021) “Study of the glycosylation-dependent interaction between NK cell receptors and Galectin-1 by microscale thermophoresis” – Short Oral Presentation

2014-2015, Erasmus Exchange Programme, Biochemistry, Faculty of Science, Charles University

2020, Short-term scientific mission (STSM), “Selection of a nanobody against NKp30, an activation receptor of NK cells”, Laboratory for Environmental and Life Sciences, University of Nova Gorica, Slovenia

2020-2022, Grant Agency of the Charles University project 1436220, “Activation of NK cell anti-tumour response using bispecific fusion proteins with nanobodies”, Faculty of Science, Charles University, principal investigator

2019-2023 – STARS Ph.D. Scholarship