Postdoctoral fellow at Charles University, Prague, Czech Republic
Education
2016 – 2021
Doctoral programme
Biochemistry
Charles University, Faculty of Science
2016 – 2021
2014 – 2016
Master programme
Clinical and Toxicological Analysis
Charles University, Faculty of Science
2014 – 2016
2010 – 2014
Bachelor programme
Clinical and Toxicological Analysis
Charles University, Faculty of Science
2010 – 2014
Publication
| 2022 | Bláha J., Skálová T., Kalousková B., Skořepa O., Cmunt D., Grobárová V., Pazicky S., Poláchová E., Abreu C., Stránský J., Kovaľ T., Dušková J., Zhao Y., Harlos K., Hašek J., Dohnálek J., Vaněk O. (2022): Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse. Nat Commun 13, 5022. IF 17.694 DOI: 10.1038/s41467-022-32577-6 |
| 2022 | Vaněk O., Kalousková B., Abreu C., Nejadebrahim S., Skořepa O. (2022): Natural killer cell-based strategies for immunotherapy of cancer. Adv Protein Chem Struct Biol 129, 91-133. IF 5.447 DOI: 10.1016/bs.apcsb.2022.02.001 |
| 2021 | Peleg Y., Vincentelli R., Collins B. M., Chen K., Livingstone E. K., Weeratunga S., Leneva N., Guo Q., Remans K., Perez K., Bjerga G. E. K., Larsen Ø., Vaněk O., Skořepa O., Jacquemin S., Poterszman A., Kjaer S., Christodoulou E., Albeck S., Dym O., Ainbinder E., Unger T., Schuetz A., Matthes S., Bader M., de Marco A., Storici P., Semrau M. S., Stolt-Bergner P., Aigner C., Suppmann S., Goldenzweig A., Fleishman S. J. (2021): Community-wide experimental evaluation of the PROSS stability-design method. J Mol Biol 433, 166964. IF 6.151 DOI: 10.1016/j.jmb.2021.166964 |
| 2021 | Kalousková B., Skořepa O., Cmunt D., Abreu C., Krejčová K., Bláha J., Sieglová I., Král V., Fábry M., Pola R., Pechar M., Vaněk O. (2021): Tumor marker B7-H6 bound to the coiled coil peptide-polymer conjugate enables targeted therapy by activating human natural killer cells. Biomedicines 9, 1597. IF 4.757 DOI: 10.3390/biomedicines9111597 |
| 2020 | Skořepa O., Pažický S., Kalousková B., Bláha J., Abreu C., Ječmen T., Rosůlek M., Fish A., Sedivy A., Harlos K., Dohnálek J., Skálová T., Vaněk O.* (2020): Natural killer cell activation receptor NKp30 oligomerization depends on its N-glycosylation. Cancers 12, 1998. IF 6.639 DOI: 10.3390/cancers12071998 |
| 2019 | Vaněk O., Celadová P., Skořepa O., Bláha J., Kalousková B., Dvorská A., Poláchová E., Pucholtová H., Kavan D., Pompach P., Hofbauerová K., Kopecký V. Jr., Mesci A., Voigt S., Carlyle J. R. (2019): Production of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells. Sci Rep 9, 17836. IF 3.998 DOI: 10.1038/s41598-019-52114-8 |
| 2017 | Bláha J., Kalousková B., Skořepa O., Pažický S., Novák P., Vaněk O. (2017): High-level expression and purification of soluble form of human natural killer cell receptor NKR-P1 in HEK293S GnTI– cells. Protein Expr Purif 140, 36-43. IF 1.338 DOI: 10.1016/j.pep.2017.07.016 |
Presentations at scientific conferences
| 2021 | EBSA 13TH European Biophysics Conference, Vienna, Austria |
| 2020 | FEBS/INSTRUCT/ARBRE-MOBIEU HYTHABIO Practical Course, Grenoble, France |
| 2020 | ARBRE-MOBIEU 4th Plenary meeting, Prague, Czech Republic, Co-organiser |
| 2019 | British Society for Immunology Congress 2019, Liverpool, GB |
| 2019 | ARBRE-MOBIEU Plenary Meeting COST action CA15126, Zagreb, Croatia |
| 2018 | EMBO Practical Course Membrane PEPC1, Hamburg, Germany |
| 2018 | FEBS Course on Hydrodynamic and Thermodynamic Analysis of Biological Macromolecules and Their Interactions, Co-organiser |
| 2017 | Structural Mass Spectrometry Workshop, Weizmann institute of science, Rehovot, Israel |
| 2017 | Instruct Biennial Structural Biology Meeting 2017, Brno, Czech Republic |
| 2017 | 2nd iNEXT Annual User Meeting in Brno |
| 2017 | ARBRE-MOBIEU Porto plenary meeting, Porto, Portugal |
| 2016 | Helmholtz Training Course on Integrative Structural Biology Braunschweig, Germany |
| 2016 | FEBS practical course “Advanced Methods in Macromolecular Crystallization VII”, Nové Hrady, Czech Republic |
| 2016 | XIV Discussions in Structural Molecular Biology in Nové Hrady, Czech Republic |
| 2015 | XVII. Meeting of Biochemists and Molecular Biologists, Brno, Czech Republic |
Selected research projects
| 2023 | A New Vision: Innovative Imaging Approaches for Investigating the Spatial Organization of Immune Receptors and Ligands. Czech Science Foundation (24-12553O), postdoc individual fellowship outgoing project, 2024 – 2027, principal investigator |
| 2017 | SEC-SAXS measurements, Diamond synchrotron, Harwell, UK |
| 2017 | COST Short Term Scientific Mission, Impact of NKp30 glycosylation and oligomerization on its complex formation and ligand binding – the key features for NK cells activation, Netherlands Cancer Institute, Amsterdam, Netherlands |
| 2016 | Impact of NKp30 glycosylation and oligomerization on its complex formation – the key features for NK cells activation. Grant Agency of the Charles University (927916), 2016 – 2018, principal investigator |
Last updated 10. 1. 2024