Projects and grants

Currently running

A New Vision: Innovative Imaging Approaches for Investigating the Spatial Organization of
Immune Receptors and Ligands

Principal investigator: O. Skořepa

Hosts: Prof. Dr. Ralf Jungmann, Prof. Dr. Petra Schwille, Max Planck Institute of Biochemistry, Germany

Grantor: Czech Science Foundation

Duration: 2024 – 2027

Grant number: 24-12553O

Nanoscale organisation of NK cell receptor-ligand complexes through the optics of
quantitative single-molecule microscopy

Principal investigator: O. Vaněk

Co-investigators: Dr. Mario Brameshuber, Technical University of Vienna, Austria

Co-investigators: assoc. prof. Ario de Marco, University Nova Gorica, Slovenia

Grantor: Czech Science Foundation

Duration: 2023 – 2026

Grant number: 23-08490L

Novel recombinant immunocytokines to stimulate the anti-tumour immune response

Utilising sortase A for the preparation of polymer immunotherapeutics and determining their antitumour activity

Interaction of galectin-3 with the NKp30 receptor and its role in the antitumor immune response

Activation receptor NKp80 and its ligand AICL: structure and mutual interaction in solution and on the surface of human NK cells

Glycan-dependent regulation of NK cell recognition: structural biology and novel methods of glycopeptide analysis

Activation of NK cell anti-tumour response using bispecific fusion proteins with nanobodies

Structural biochemistry of NK cell complexes NKp44:PCNA and NKp46:Epa1, and utilization of Epa1 for stimulation of NK cells

Novel clinically relevant IL-2 immunotherapeutics for cancer treatment

Quaternary structure of selected human lymphocyte receptors through the looking glass of super-resolution microscopy: What is the biological reality behind the crystal structures?

Utilization of activation ligands and nanobodies for directed stimulation of NK cells cytotoxicity

New ligands for old receptors of human natural killer cells: structure, assembly within the immune synapse and potential for therapy

Utilization of integrative molecular biophysical approaches for the functional studies of human natural killer cell receptors and formation of their complexes with tumour ligands

Impact of NKp30 glycosylation and oligomerization on its complex formation – the key features for NK cells activation

Utilization of a structural description of the interaction of human lymphocyte complex NKR-P1 and LLT1 for development of immunoactive fusion therapeutics

Harnessing soluble forms of NK cell receptors and their ligands for the generation of novel anticancer immunotherapeutics