Paper alert

Cells talk to one another all the time using cascades of protein interactions. Now, we know for quite some time that proteins from different cascades can interact with each other. It’s called crosstalk. But doesn’t it defy the logic of clear communication channels between cells? 🧐
Together with the team of Jakub Harnoš, we compiled available knowledge about direct interactions between Wnt and Notch components and proposed a model of how the crosstalk is utilized to provide a more polarized cellular response to one pathway or another.
Huge thanks to the team that worked on this review, Fabio Turetti, Marek Dokoupil, and the one and only Giovanna Collu. We are finishing a research article probing new Wntch interactions, so stay tuned for more :).
https://royalsocietypublishing.org/rsob/article/16/1/250282/479550/Decoding-Wntch-the-intertwined-Wnt-and-Notch