Laboratory of Biophysical Chemistry Charles University in Prague, Faculty of Science
Department of Physical and Macromolecular Chemistry
Hlavova 8, 12843 Prague 2
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Biophysical chemistry applies fundamental principles from physics, chemistry and biology to gain molecular and structural insights into the mechanisms and mechanics of medically relevant biological processes.
We study molecular mechanisms by which protein function can be regulated. In particular, we are interested in 14-3-3 proteins, a family of highly conserved dimeric regulatory proteins. We employ both biophysical (fluorescence spectroscopy, X-ray crystallography, protein structure modeling, molecular dynamics simulations) and biochemical (site-directed mutagenesis) approaches to understand the details of how the activity and function of protein-protein complexes are regulated.
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