POSITIONS AVAILABLE FOR MOTIVATED STUDENTS (Bc., NMgr., Ph.D. study)

Please contact prof. Tomas Obsil (obsil@natur.cuni.cz) for more details. 

Klara Kohoutova, Pavel Srb, Veronika Obsilova, Vaclav Veverka and Tomas Obsil

Structural Plasticity of the FOXO-DBD:p53-TAD Interaction | Nature Communications

Masa Janosev, Dalibor Kosek, Andrej Tekel,  Rohit Joshi, Karolina Honzejkova, Pavel Pohl, Tomas Obsil and Veronika Obsilova

Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins | Nature Communications

Klara Kohoutova won the Prize of the Czech Society for Structural Biology for an outstanding student presentation for her talk entitled "Structural Basis of the 14-3-3/Cyclin Y-mediated Regulation of CDK16" at XXI Discussions in Structural Molecular Biology and 8th User Meeting of CIISB (Czech Infrastructure for Integrative Structural Biology), Nové Hrady, South Bohemia, 20-22 March 2025.

Honzejkova K, Kosek D, Obsilova V, Obsil T.

The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1.

Petrvalska O, Honzejkova K, Koupilova N, Herman P, Obsilova V, Obsil T.

14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices.

25 March 2023: Karolina Honzejková won the Czech Society for Structural Biology Award for Outstanding Student Presentation.

Klara Kohoutova, Vojtěch Dočekal, Michael J. Ausserlechner, Nora Kaiser, Andrej Tekel, Raju Mandal, Matej Horvath, Veronika Obsilova, Jan Vesely, Judith Hagenbuchner and Tomas Obsil

Lengthening the Guanidine–Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription

Veronika Obsilova and Tomas Obsil

Structural insights into the functional roles of 14-3-3 proteins

FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA.

Joshi R, Pohl P, Strachotova D, Herman P, Obsil T, Obsilova V.

Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains.

Pavel Pohl, Rohit Joshi, Olivia Petrvalska, Tomas Obsil and Veronika Obsilova

14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains | Communications Biology (nature.com)

Matej Horvath, Olivia Petrvalska, Petr Herman, Veronika Obsilova and Tomas Obsil 

14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites | Communications Biology (nature.com)

PhD Thesis: Domenico Lentini Santo

Master thesis: Nicola Koupilová

Phosphorylated full-length Tau interacts with 14-3-3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14-3-3 dimer

https://www.ncbi.nlm.nih.gov/pubmed/32979285

Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins

https://www.ncbi.nlm.nih.gov/pubmed/33146997

Master thesis: Klára Kohoutová and Martina Mikulů

Bachelor thesis: Adéla Hofmanová

14-3-3 protein binding blocks the dimerization interface of caspase-2

https://www.ncbi.nlm.nih.gov/pubmed/31961068

The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress

https://www.ncbi.nlm.nih.gov/pubmed/31623019

Recently taken photo together with Obsilova group at BIOCEV in Vestec.