Publications

Machara, A.; D. Cox, P.; Hudlicky, T. Direct Synthesis of Naltrexone by Palladium-Catalyzed N -Demethylation/Acylation of Oxymorphone: The Benefit of CH Activation and the Intramolecular Acyl Transfer from C-14 Hydroxy. Advanced Synthesis & Catalysis 2012, 354 (14-15), 2713-2718 DOI: 10.1002/adsc.201200677.

Riedl, J.; Ménová, P.; Pohl, R.; Orság, P.; Fojta, M.; Hocek, M. GFP-like Fluorophores as DNA Labels for Studying DNA–Protein Interactions. The Journal of Organic Chemistry 2012, 77 (18), 8287-8293 DOI: 10.1021/jo301684b.

Machara, A.; Werner, L.; Endoma-Arias, M. Ann; D. Cox, P.; Hudlicky, T. Improved Synthesis of Buprenorphine from Thebaine and/or Oripavine via Palladium-Catalyzed N-Demethylation/Acylation and/or Concomitant O-Demethylation. Advanced Synthesis & Catalysis 2012, 354 (4), 613-626 DOI: 10.1002/adsc.201100807.

Ménová, P.; Hocek, M. Preparation of short cytosine-modified oligonucleotides by nicking enzyme amplification reaction. Chemical Communications 2012, 48 (55), 6921 DOI: 10.1039/c2cc32930a.

Perlíková, P.; Martínez, N. Jornet; Slavětínská, L.; Hocek, M. Synthesis of 2′-deoxy-2′-fluororibo- and 2′-deoxy-2′,2′-difluororibonucleosides derived from 6-(het)aryl-7-deazapurines. Tetrahedron 2012, 68 (39), 8300-8310 DOI: 10.1016/j.tet.2012.07.033.

Werner, L.; Wernerova, M.; Machara, A.; Endoma-Arias, M. Ann; Duchek, J.; Adams, D. R.; D. Cox, P.; Hudlicky, T. Unexpected N -Demethylation of Oxymorphone and Oxycodone N -Oxides Mediated by the Burgess Reagent: Direct Synthesis of Naltrexone, Naloxone, and Other Antagonists from Oxymorphone. Advanced Synthesis & Catalysis 2012, 354 (14-15), 2706-2712 DOI: 10.1002/adsc.201200676.

Gülak, S.; Štěpánek, O.; Malberg, J.; Rad, B. Rezaei; Kotora, M.; Wolf, R.; von Wangelin, A. Jacobi. Highly chemoselective cobalt-catalyzed biaryl coupling reactions. Chem. Sci. 2013, 4 (2), 776-784 DOI: 10.1039/C2SC21667A.

Fanfrlík, J.; Kolář, M.; Kamlar, M.; Hurný, D.; Ruiz, F. X.; Cousido-Siah, A.; Mitschler, A.; Řezáč, J.; Munusamy, E.; Lepšík, M.; et al. Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning. ACS Chemical Biology 2013, 8 (11), 2484-2492 DOI: 10.1021/cb400526n.

Fanfrlík, J.; Kolář, M.; Kamlar, M.; Hurný, D.; Ruiz, F. X.; Cousido-Siah, A.; Mitschler, A.; Řezáč, J.; Munusamy, E.; Lepšík, M.; et al. Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning. ACS Chemical Biology 2013, 8 (11), 2484-2492 DOI: 10.1021/cb400526n.

Fanfrlík, J.; Kolář, M.; Kamlar, M.; Hurný, D.; Ruiz, F. X.; Cousido-Siah, A.; Mitschler, A.; Řezáč, J.; Munusamy, E.; Lepšík, M.; et al. Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning. ACS Chemical Biology 2013, 8 (11), 2484-2492 DOI: 10.1021/cb400526n.

Ménová, P.; Cahová, H.; Plucnara, M.; Havran, L.; Fojta, M.; Hocek, M. Polymerase synthesis of oligonucleotides containing a single chemically modified nucleobase for site-specific redox labelling. Chemical Communications 2013, 49 (41), 4652 DOI: 10.1039/c3cc41438h.

Ménová, P.; Raindlová, V.; Hocek, M. Scope and Limitations of the Nicking Enzyme Amplification Reaction for the Synthesis of Base-Modified Oligonucleotides and Primers for PCR. Bioconjugate Chemistry 2013, 24 (6), 1081-1093 DOI: 10.1021/bc400149q.

Perlíková, P.; Eberlin, L.; Ménová, P.; Raindlová, V.; Slavětínská, L.; Tloušťová, E.; Bahador, G.; Lee, Y. - J.; Hocek, M. Synthesis and Cytostatic and Antiviral Activities of 2′-Deoxy-2′,2′-difluororibo- and 2′-Deoxy-2′-fluororibonucleosides Derived from 7-(Het)aryl-7-deazaadenines. ChemMedChem 2013, 8 (5), 832-846 DOI: 10.1002/cmdc.201300047.

Machara, A.; Svoboda, J. Thiophenium-ylides: Synthesis and reactivity. Chemical Papers 2013, 67 (1) DOI: 10.2478/s11696-012-0222-7.

Murphy, B.; Šnajdr, I.; Machara, A.; Endoma-Arias, M. Ann A.; Stamatatos, T. C.; D. Cox, P.; Hudlicky, T. Conversion of Thebaine to Oripavine and Other Useful Intermediates for the Semisynthesis of Opiate-Derived Agents: Synthesis of Hydromorphone. Advanced Synthesis & Catalysis 2014, 356 (11-12), 2679-2687 DOI: 10.1002/adsc.201400445.

Murphy, B.; Šnajdr, I.; Machara, A.; Endoma-Arias, M. Ann A.; Stamatatos, T. C.; D. Cox, P.; Hudlicky, T. Conversion of Thebaine to Oripavine and Other Useful Intermediates for the Semisynthesis of Opiate-Derived Agents: Synthesis of Hydromorphone. Advanced Synthesis & Catalysis 2014, 356 (11-12), 2679-2687 DOI: 10.1002/adsc.201400445.

Motloch, P.; Valterová, I.; Kotora, M. Enantioselective Allylation of Thiophene-2-carbaldehyde: Formal Total Synthesis of Duloxetine. Advanced Synthesis & Catalysis 2014, 356 (1), 199-204 DOI: 10.1002/adsc.201300849.

Hanzlová, E.; Váňa, J.; Shaffer, C. J.; Roithová, J.; Martinů, T. Evidence for the Cyclic CN ₂ Carbene in the Gas Phase. Organic Letters 2014, 16 (20), 5482-5485 DOI: 10.1021/ol5027602.

Tumova, L.; Pombinho, A. R.; Vojtechova, M.; Stancikova, J.; Gradl, D.; Krausova, M.; Sloncova, E.; Horazna, M.; Kriz, V.; Machonova, O.; et al. Monensin inhibits canonical wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice. Molecular cancer therapeutics 2014, 13 (4), 812-822 DOI: 10.1158/1535-7163.MCT-13-0625.

Mačková, M.; Pohl, R.; Hocek, M. Polymerase Synthesis of DNAs Bearing Vinyl Groups in the Major Groove and their Cleavage by Restriction Endonucleases. ChemBioChem 2014, 15 (15), 2306-2312 DOI: 10.1002/cbic.201402319.

Ceban, V.; Putaj, P.; Meazza, M.; Pitak, M. B.; Coles, S. J.; Vesely, J.; Rios, R. Synergistic catalysis: highly diastereoselective benzoxazole addition to Morita–Baylis–Hillman carbonates. Chemical Communications 2014, 50 (56), 7447 DOI: 10.1039/c4cc00728j.

Dhami, K.; Malyshev, D. A.; Ordoukhanian, P.; Kubelka, T.; Hocek, M.; Romesberg, F. E. Systematic exploration of a class of hydrophobic unnatural base pairs yields multiple new candidates for the expansion of the genetic alphabet. Nucleic Acids Research 2014, 42 (16), 10235-10244 DOI: 10.1093/nar/gku715.

Kaiser, R. P.; Hessler, F.; Mosinger, J.; Císařová, I.; Kotora, M. A [2+2+2]-Cyclotrimerization Approach to Selectively Substituted Fluorenes and Fluorenols, and Their Conversion to 9,9′-Spirobifluorenes. Chemistry - A European Journal 2015, 21 (39), 13577-13582 DOI: 10.1002/chem.201502370.

Malnuit, V.; Slavětínská, L. Poštová; Nauš, P.; Džubák, P.; Hajdúch, M.; Stolaříková, J.; Snášel, J.; Pichová, I.; Hocek, M. 2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity. ChemMedChem 2015, 10 (6), 1079-1093 DOI: 10.1002/cmdc.201500081.

Olszewska, A.; Dadová, J.; Mačková, M.; Hocek, M. Cleavage of DNA containing 5-fluorocytosine or 5-fluorouracil by type II restriction endonucleases. Bioorganic & Medicinal Chemistry 2015, 23 (21), 6885-6890 DOI: 10.1016/j.bmc.2015.09.051.