Publications

Found 157 results
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2014
Mačková, M.; Pohl, R.; Hocek, M. Polymerase Synthesis of DNAs Bearing Vinyl Groups in the Major Groove and their Cleavage by Restriction Endonucleases. ChemBioChem 2014, 15 (15), 2306-2312 DOI: 10.1002/cbic.201402319.
Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; et al. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (20), 8268-8279 DOI: 10.1021/jm500497v.
Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; et al. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (20), 8268-8279 DOI: 10.1021/jm500497v.
Ceban, V.; Putaj, P.; Meazza, M.; Pitak, M. B.; Coles, S. J.; Vesely, J.; Rios, R. Synergistic catalysis: highly diastereoselective benzoxazole addition to Morita–Baylis–Hillman carbonates. Chemical Communications 2014, 50 (56), 7447 DOI: 10.1039/c4cc00728j.
Ceban, V.; Putaj, P.; Meazza, M.; Pitak, M. B.; Coles, S. J.; Vesely, J.; Rios, R. Synergistic catalysis: highly diastereoselective benzoxazole addition to Morita–Baylis–Hillman carbonates. Chemical Communications 2014, 50 (56), 7447 DOI: 10.1039/c4cc00728j.
Nauš, P.; Caletková, O.; Konečný, P.; Džubák, P.; Bogdanová, K.; Kolář, M.; Vrbková, J.; Slavětínská, L.; Tloušt’ová, E.; Perlíková, P.; et al. Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (3), 1097-1110 DOI: 10.1021/jm4018948.
Algara-Siller, G.; Severin, N.; Chong, S. Y.; Björkman, T.; Palgrave, R. G.; Laybourn, A.; Antonietti, M.; Khimyak, Y. Z.; Krasheninnikov, A. V.; Rabe, J. P.; et al. Triazine-Based Graphitic Carbon Nitride: a Two-Dimensional Semiconductor. Angewandte Chemie International Edition 2014, 53 (29), 7450-7455 DOI: 10.1002/anie.201402191.
Algara-Siller, G.; Severin, N.; Chong, S. Y.; Björkman, T.; Palgrave, R. G.; Laybourn, A.; Antonietti, M.; Khimyak, Y. Z.; Krasheninnikov, A. V.; Rabe, J. P.; et al. Triazine-Based Graphitic Carbon Nitride: a Two-Dimensional Semiconductor. Angewandte Chemie 2014, 126 (29), 7580-7585 DOI: 10.1002/ange.201402191.
2013
Perlíková, P.; Konečný, P.; Nauš, P.; Snášel, J.; Votruba, I.; Džubák, P.; Pichová, I.; Hajdúch, M.; Hocek, M. 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. MedChemComm 2013, 4 (11), 1497 DOI: 10.1039/c3md00232b.
Perlíková, P.; Konečný, P.; Nauš, P.; Snášel, J.; Votruba, I.; Džubák, P.; Pichová, I.; Hajdúch, M.; Hocek, M. 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. MedChemComm 2013, 4 (11), 1497 DOI: 10.1039/c3md00232b.
Dadová, J.; Vidláková, P.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M. Aqueous Heck Cross-Coupling Preparation of Acrylate-Modified Nucleotides and Nucleoside Triphosphates for Polymerase Synthesis of Acrylate-Labeled DNA. The Journal of Organic Chemistry 2013, 78 (19), 9627-9637 DOI: 10.1021/jo4011574.
Balintová, J.; Plucnara, M.; Vidláková, P.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M. Benzofurazane as a New Redox Label for Electrochemical Detection of DNA: Towards Multipotential Redox Coding of DNA Bases. Chemistry - A European Journal 2013, 19 (38), 12720-12731 DOI: 10.1002/chem.201301868.
Balintová, J.; Plucnara, M.; Vidláková, P.; Pohl, R.; Havran, L.; Fojta, M.; Hocek, M. Benzofurazane as a New Redox Label for Electrochemical Detection of DNA: Towards Multipotential Redox Coding of DNA Bases. Chemistry - A European Journal 2013, 19 (38), 12720-12731 DOI: 10.1002/chem.201301868.
Klečka, M.; Pohl, R.; Čejka, J.; Hocek, M. Direct C–H sulfenylation of purines and deazapurines. Organic & Biomolecular Chemistry 2013, 11 (31), 5189 DOI: 10.1039/c3ob40881g.
Fanfrlík, J.; Kolář, M.; Kamlar, M.; Hurný, D.; Ruiz, F. X.; Cousido-Siah, A.; Mitschler, A.; Řezáč, J.; Munusamy, E.; Lepšík, M.; et al. Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning. ACS Chemical Biology 2013, 8 (11), 2484-2492 DOI: 10.1021/cb400526n.
Kamlar, M.; Putaj, P.; Vesely, J. Organocatalytic alkynylation of densely functionalized monofluorinated derivatives: C(sp3)–C(sp) coupling. Tetrahedron Letters 2013, 54 (16), 2097-2100 DOI: 10.1016/j.tetlet.2013.02.023.
Ménová, P.; Cahová, H.; Plucnara, M.; Havran, L.; Fojta, M.; Hocek, M. Polymerase synthesis of oligonucleotides containing a single chemically modified nucleobase for site-specific redox labelling. Chemical Communications 2013, 49 (41), 4652 DOI: 10.1039/c3cc41438h.
Tichý, M.; Pohl, R.; Tloušt’ová, E.; Weber, J.; Bahador, G.; Lee, Y. - J.; Hocek, M. Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides. Bioorganic & Medicinal Chemistry 2013, 21 (17), 5362-5372 DOI: 10.1016/j.bmc.2013.06.011.
Perlíková, P.; Eberlin, L.; Ménová, P.; Raindlová, V.; Slavětínská, L.; Tloušťová, E.; Bahador, G.; Lee, Y. - J.; Hocek, M. Synthesis and Cytostatic and Antiviral Activities of 2′-Deoxy-2′,2′-difluororibo- and 2′-Deoxy-2′-fluororibonucleosides Derived from 7-(Het)aryl-7-deazaadenines. ChemMedChem 2013, 8 (5), 832-846 DOI: 10.1002/cmdc.201300047.
Kalachova, L.; Pohl, R.; Bednárová, L.; Fanfrlík, J.; Hocek, M. Synthesis of nucleosides and dNTPs bearing oligopyridine ligands linked through an octadiyne tether, their incorporation into DNA and complexation with transition metal cations. Org. Biomol. Chem. 2013, 11 (1), 78-89 DOI: 10.1039/C2OB26881G.
Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. Vinylsulfonamide and Acrylamide Modification of DNA for Cross-linking with Proteins. Angewandte Chemie International Edition 2013, 52 (40), 10515-10518 DOI: 10.1002/anie.201303577.
2012
Ćerňová, M.; Pohl, R.; Klepetářová, B.; Hocek, M. A General Regioselective Synthesis of 2,4-Diarylpyrimidines from 2- Thiouracil through Two Orthogonal Cross-Coupling Reactions. Synlett 2012, 23 (09), 1305-1308 DOI: 10.1055/s-0031-1290826.
Riedl, J.; Ménová, P.; Pohl, R.; Orság, P.; Fojta, M.; Hocek, M. GFP-like Fluorophores as DNA Labels for Studying DNA–Protein Interactions. The Journal of Organic Chemistry 2012, 77 (18), 8287-8293 DOI: 10.1021/jo301684b.
Riedl, J.; Pohl, R.; Ernsting, N. P.; Orság, P.; Fojta, M.; Hocek, M. Labelling of nucleosides and oligonucleotides by solvatochromic 4-aminophthalimide fluorophore for studying DNA–protein interactions. Chemical Science 2012, 3 (9), 2797 DOI: 10.1039/c2sc20404e.
Prchalová, E.; Votruba, I.; Kotora, M. Sphingosine and clavaminol H derivatives bearing fluorinated chains and their cytotoxic activity. Journal of Fluorine Chemistry 2012, 141, 49-57 DOI: 10.1016/j.jfluchem.2012.06.005.
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