Publications

Dziuba, D.; Pohl, R.; Hocek, M. Polymerase synthesis of DNA labelled with benzylidene cyanoacetamide-based fluorescent molecular rotors: fluorescent light-up probes for DNA-binding proteins. Chem. Commun. 2015, 51 (23), 4880-4882 DOI: 10.1039/C5CC00530B.

Mačková, M.; Pohl, R.; Hocek, M. Polymerase Synthesis of DNAs Bearing Vinyl Groups in the Major Groove and their Cleavage by Restriction Endonucleases. ChemBioChem 2014, 15 (15), 2306-2312 DOI: 10.1002/cbic.201402319.

Ménová, P.; Cahová, H.; Plucnara, M.; Havran, L.; Fojta, M.; Hocek, M. Polymerase synthesis of oligonucleotides containing a single chemically modified nucleobase for site-specific redox labelling. Chemical Communications 2013, 49 (41), 4652 DOI: 10.1039/c3cc41438h.

Vaníková, Z.; Hocek, M. Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases. Angewandte Chemie International Edition 2014, 53 (26), 6734-6737 DOI: 10.1002/anie.201402370.

Ménová, P.; Hocek, M. Preparation of short cytosine-modified oligonucleotides by nicking enzyme amplification reaction. Chemical Communications 2012, 48 (55), 6921 DOI: 10.1039/c2cc32930a.

Džubák, P.; Gurska, S.; Hajdúch, M.; Hocek, M.; Pohl, R.; Tloušťová, E.; Veselovská, L. Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9H-Pyrido[2',3':4,5]- and Pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidines. ACS Omega [online] 2020, 5 (40), 26278-26286 DOI: 10.1021/acsomega.0c04302.

Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy. Angewandte Chemie International Edition 2016, 55 (1), 174-178 DOI: 10.1002/anie.201507922.

Ménová, P.; Raindlová, V.; Hocek, M. Scope and Limitations of the Nicking Enzyme Amplification Reaction for the Synthesis of Base-Modified Oligonucleotides and Primers for PCR. Bioconjugate Chemistry 2013, 24 (6), 1081-1093 DOI: 10.1021/bc400149q.

Dziuba, D.; Pospíšil, P.; Matyašovský, J.; Brynda, J.; Nachtigallová, D.; Rulíšek, L.; Pohl, R.; Hof, M.; Hocek, M. Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions. Chem. Sci. 2016, 7 (9), 5775-5785 DOI: 10.1039/C6SC02548J.

Bobula, T.; Hocek, M.; Kotora, M. Sonogashira reactions of α- and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides. Tetrahedron 2010, 66 (2), 530-536 DOI: 10.1016/j.tet.2009.11.030.

Ivancova, I.; Pohl, R.; Hubalek, M.; Hocek, M. Squaramate-Modified Nucleotides and DNA for Specific Cross-Linking with Lysine-Containing Peptides and Proteins. Angewandte Chemie-International Edition 2019, 58 (38), 13345-13348 DOI: 10.1002/anie.201906737.

Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; et al. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (20), 8268-8279 DOI: 10.1021/jm500497v.

Nauš, P.; Perlíková, P.; Bourderioux, A.; Pohl, R.; Slavětínská, L.; Votruba, I.; Bahador, G.; Birkuš, G.; Cihlář, T.; Hocek, M. Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides. Bioorganic & Medicinal Chemistry 2012, 20 (17), 5202-5214 DOI: 10.1016/j.bmc.2012.07.003.

Tichý, M.; Pohl, R.; Xu, H. Ying; Chen, Y. - L.; Yokokawa, F.; Shi, P. - Y.; Hocek, M. Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Bioorganic & Medicinal Chemistry 2012, 20 (20), 6123-6133 DOI: 10.1016/j.bmc.2012.08.021.

Tichý, M.; Pohl, R.; Tloušt’ová, E.; Weber, J.; Bahador, G.; Lee, Y. - J.; Hocek, M. Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides. Bioorganic & Medicinal Chemistry 2013, 21 (17), 5362-5372 DOI: 10.1016/j.bmc.2013.06.011.

Nauš, P.; Caletková, O.; Perlíková, P.; Slavětínská, L. Poštová; Tloušťová, E.; Hodek, J.; Weber, J.; Džubák, P.; Hajdúch, M.; Hocek, M. Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4′-C-methylribonucleosides. Bioorganic & Medicinal Chemistry 2015, 23 (23), 7422-7438 DOI: 10.1016/j.bmc.2015.10.040.

Bartova, K.; Džubák, P.; Fleuti, M. Heidi; Gurska, S.; Hajdúch, M.; Hocek, M.; Pavliš, P.; Slavětínská, L. Poštová; Tichý, M.; Tloušťová, E. Synthesis and Biological Profiling of Pyrazolo-Fused 7-Deazapurine Nucleosides. Journal of Organic Chemistry 2020, 85 (16), 10539-10551 DOI: 10.1021/acs.joc.0c00928.

Klečka, M.; Slavětínská, L. Poštová; Tloušťová, E.; Džubák, P.; Hajdúch, M.; Hocek, M. Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides. Med. Chem. Commun. 2015, 6 (4), 576-580 DOI: 10.1039/C4MD00492B.

Perlíková, P.; Eberlin, L.; Ménová, P.; Raindlová, V.; Slavětínská, L.; Tloušťová, E.; Bahador, G.; Lee, Y. - J.; Hocek, M. Synthesis and Cytostatic and Antiviral Activities of 2′-Deoxy-2′,2′-difluororibo- and 2′-Deoxy-2′-fluororibonucleosides Derived from 7-(Het)aryl-7-deazaadenines. ChemMedChem 2013, 8 (5), 832-846 DOI: 10.1002/cmdc.201300047.

Nauš, P.; Caletková, O.; Konečný, P.; Džubák, P.; Bogdanová, K.; Kolář, M.; Vrbková, J.; Slavětínská, L.; Tloušt’ová, E.; Perlíková, P.; et al. Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (3), 1097-1110 DOI: 10.1021/jm4018948.

Kubelka, T.; Slavětínská, L.; Eigner, V.; Hocek, M. Synthesis of 2,6-disubstituted pyridin-3-yl C-2′-deoxyribonucleosides through chemoselective transformations of bromo-chloropyridine C-nucleosides. Organic & Biomolecular Chemistry 2013, 11 (28), 4702 DOI: 10.1039/c3ob40774h.

Perlíková, P.; Martínez, N. Jornet; Slavětínská, L.; Hocek, M. Synthesis of 2′-deoxy-2′-fluororibo- and 2′-deoxy-2′,2′-difluororibonucleosides derived from 6-(het)aryl-7-deazapurines. Tetrahedron 2012, 68 (39), 8300-8310 DOI: 10.1016/j.tet.2012.07.033.

Chapuis, H.; Kubelka, T.; Joubert, N.; Pohl, R.; Hocek, M. Synthesis of 6-Substituted 2(1H)-Pyridon-3-yl C-2′-Deoxyribonucleosides. European Journal of Organic Chemistry 2012, 2012 (9), 1759-1767 DOI: 10.1002/ejoc.201101662.

Raindlová, V.; Pohl, R.; Hocek, M. Synthesis of Aldehyde-Linked Nucleotides and DNA and Their Bioconjugations with Lysine and Peptides through Reductive Amination. Chemistry - A European Journal 2012, 18 (13), 4080-4087 DOI: 10.1002/chem.201103270.

Hocek, M. Synthesis of Base-Modified 2′-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology. The Journal of Organic Chemistry 2014, 79 (21), 9914-9921 DOI: 10.1021/jo5020799.