Publications
Modification of Pyrrolo[2,3-d]pyrimidines by C-H Borylation Followed by Cross-Coupling or Other Transformations: Synthesis of 6,8-Disubstituted 7-Deazapurine Bases. European Journal of Organic Chemistry 2015, 2015 (36), 7943-7961 DOI: 10.1002/ejoc.201501177.
Polymerase Synthesis and Restriction Enzyme Cleavage of DNA Containing 7-Substituted 7-Deazaguanine Nucleobases. ChemBioChem 2015, 16 (15), 2225-2236 DOI: 10.1002/cbic.201500315.
Polymerase synthesis of DNA labelled with benzylidene cyanoacetamide-based fluorescent molecular rotors: fluorescent light-up probes for DNA-binding proteins. Chem. Commun. 2015, 51 (23), 4880-4882 DOI: 10.1039/C5CC00530B.
Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4′-C-methylribonucleosides. Bioorganic & Medicinal Chemistry 2015, 23 (23), 7422-7438 DOI: 10.1016/j.bmc.2015.10.040.
Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides. Med. Chem. Commun. 2015, 6 (4), 576-580 DOI: 10.1039/C4MD00492B.
Synthesis of Benzene and Pyridine 2-C-Methyl-C-ribonucleosides and -nucleotides. European Journal of Organic Chemistry 2015, 2015 (36), 7962-7983 DOI: 10.1002/ejoc.201501219.
2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove. Angewandte Chemie International Edition 2016, 55 (51), 15856-15859 DOI: 10.1002/anie.201609007.
5-Substituted Pyrimidine and 7-Substituted 7-Deazapurine dNTPs as Substrates for DNA Polymerases in Competitive Primer Extension in the Presence of Natural dNTPs. ACS Chemical Biology 2016, 11 (11), 3165-3171 DOI: 10.1021/acschembio.6b00714.
6-Aryl-4-amino-pyrimido[4,5-b]indole 2′-deoxyribonucleoside triphosphates (benzo-fused 7-deaza-dATP analogues): Synthesis, fluorescent properties, enzymatic incorporation into DNA and DNA-protein binding study. Bioorganic & Medicinal Chemistry 2016, 24 (19), 4528-4535 DOI: 10.1016/j.bmc.2016.07.054.
Additions of Thiols to 7-Vinyl-7-deazaadenine Nucleosides and Nucleotides. Synthesis of Hydrophobic Derivatives of 2′-Deoxyadenosine, dATP and DNA. The Journal of Organic Chemistry 2016, 81 (22), 11115-11125 DOI: 10.1021/acs.joc.6b02098.
Chloroacetamide-Linked Nucleotides and DNA for Cross-Linking with Peptides and Proteins. Bioconjugate Chemistry 2016, 27 (9), 2089-2094 DOI: 10.1021/acs.bioconjchem.6b00342.
Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides. Org. Biomol. Chem. 2016, 14 (42), 10018-10022 DOI: 10.1039/C6OB01917J.
C–H Phosphonation of Pyrrolopyrimidines: Synthesis of Substituted 7- and 9-Deazapurine-8-phosphonate Derivatives. The Journal of Organic Chemistry 2016, 81 (19), 9507-9514 DOI: 10.1021/acs.joc.6b01970.
Flexible double-headed cytosine-linked 2′-deoxycytidine nucleotides. Synthesis, polymerase incorporation to DNA and interaction with DNA methyltransferases. Bioorganic & Medicinal Chemistry 2016, 24 (6), 1268-1276 DOI: 10.1016/j.bmc.2016.01.057.
Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases. Nucleic Acids Research 2016, 44 (7), 3000-3012 DOI: 10.1093/nar/gkw171.
Inhibition of non-templated nucleotide addition by DNA polymerases in primer extension using twisted intercalating nucleic acid modified templates. Bioorganic & Medicinal Chemistry Letters 2016, 26 (2), 288-291 DOI: 10.1016/j.bmcl.2015.12.034.
Polymerase Synthesis of Base-Modified DNA; Springer International Publishing: Cham, 2016; Vol. 31, pp 123-144.
A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy. Angewandte Chemie International Edition 2016, 55 (1), 174-178 DOI: 10.1002/anie.201507922.
Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions. Chem. Sci. 2016, 7 (9), 5775-5785 DOI: 10.1039/C6SC02548J.
Synthesis of Fluorescent 2-Substituted 6-(Het)aryl-7-deazapurine Bases {4-(Het)aryl-pyrrolo[2,3-d]pyrimidines} by Aqueous Suzuki–Miyaura Cross-Coupling Reactions. Synthesis 2016, 48 (07), 1029-1045 DOI: 10.1055/s-0035-1561287.
Voltammetric analysis of 5-(4-Azidophenyl)-2′-deoxycytidine nucleoside and azidophenyl-labelled single- and double-stranded DNAs. Electrochimica Acta 2016, 215, 72-83 DOI: 10.1016/j.electacta.2016.08.096.
5-(Hydroxymethyl) uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chemical Communications 2017, 53 (99), 13253-13255 DOI: 10.1039/c7cc08053k.
Carborane-linked 2 '-deoxyuridine 5 '-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA. Bioorganic & Medicinal Chemistry Letters 2017, 27 (21), 4786-4788 DOI: 10.1016/j.bmcl.2017.09.064.
Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism. Chemistry-a European Journal 2017, 23 (16), 3910-3917 DOI: 10.1002/chem.201604955.
2-Allyl- and Propargylamino-dATPs for Site-Specific Enzymatic Introduction of a Single Modification in the Minor Groove of DNA. Chemistry-a European Journal 2018, 24 (56), 14938-14941 DOI: 10.1002/chem.201803973.