Publications

Found 276 results
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Book Chapter
Nakatani, K.; Tor, Y.; Dadová, J.; Cahová, H.; Hocek, M. Polymerase Synthesis of Base-Modified DNA; Springer International Publishing: Cham, 2016; Vol. 31, pp 123-144.
Journal Article
Kotora, M.; Hocek, M.; Turek, P.; Pohl, R.; Klepetářová, B.; Votruba, I.; Opekar, S. [2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with α,ω-Diynes. HETEROCYCLES 2010, 82 (1), 895 DOI: 10.3987/COM-10-S(E)56.
Kaiser, R. P.; Hessler, F.; Mosinger, J.; Císařová, I.; Kotora, M. A [2+2+2]-Cyclotrimerization Approach to Selectively Substituted Fluorenes and Fluorenols, and Their Conversion to 9,9′-Spirobifluorenes. Chemistry - A European Journal 2015, 21 (39), 13577-13582 DOI: 10.1002/chem.201502370.
Matyašovský, J.; Pohl, R.; Hocek, M. 2-Allyl- and Propargylamino-dATPs for Site-Specific Enzymatic Introduction of a Single Modification in the Minor Groove of DNA. Chemistry-a European Journal 2018, 24 (56), 14938-14941 DOI: 10.1002/chem.201803973.
Brunderová, M.; Hocek, M.; Ivancova, I.; Krömer, M.; Slavětínská, L. Poštová. 2-Formyl-dATP as Substrate for Polymerase Synthesis of Reactive DNA Bearing an Aldehyde Group in the Minor Groove. ChemPlusChem 2020, 85 (6), 1164-1170 DOI: 10.1002/cplu.202000287.
Hocek, M.; Matyašovský, J. 2-Substituted 2 '-deoxyinosine 5 '-triphosphates as substrates for polymerase synthesis of minor-groove-modified DNA and effects on restriction endonuclease cleavage. Organic and Biomolecular Chemistry 2020, 18 (2), 255-262 DOI: 10.1039/c9ob02502b.
Malnuit, V.; Slavětínská, L. Poštová; Nauš, P.; Džubák, P.; Hajdúch, M.; Stolaříková, J.; Snášel, J.; Pichová, I.; Hocek, M. 2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity. ChemMedChem 2015, 10 (6), 1079-1093 DOI: 10.1002/cmdc.201500081.
Malnuit, V.; Slavětínská, L. Poštová; Nauš, P.; Džubák, P.; Hajdúch, M.; Stolaříková, J.; Snášel, J.; Pichová, I.; Hocek, M. 2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity. ChemMedChem 2015, 10 (6), 1079-1093 DOI: 10.1002/cmdc.201500081.
Matyašovský, J.; Perlíková, P.; Malnuit, V.; Pohl, R.; Hocek, M. 2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove. Angewandte Chemie International Edition 2016, 55 (51), 15856-15859 DOI: 10.1002/anie.201609007.
Drastík, M.; Holas, O.; Hroch, M.; Hutníková, M.; Kašpar, M.; Kudová, E.; Mičuda, S.; Pandey, A. V.; Pávek, P.; Smutný, T.; et al. 3 beta-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3 alpha-epimer by hepatic metabolism. Journal of Steroid Biochemistry and Molecular Biology 2020, 202 (September), nestránkováno DOI: 10.1016/j.jsbmb.2020.105702.
Drastík, M.; Holas, O.; Hroch, M.; Hutníková, M.; Kašpar, M.; Kudová, E.; Mičuda, S.; Pandey, A. V.; Pávek, P.; Smutný, T.; et al. 3 beta-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3 alpha-epimer by hepatic metabolism. Journal of Steroid Biochemistry and Molecular Biology 2020, 202 (September), nestránkováno DOI: 10.1016/j.jsbmb.2020.105702.
Drastík, M.; Holas, O.; Hroch, M.; Hutníková, M.; Kašpar, M.; Kudová, E.; Mičuda, S.; Pandey, A. V.; Pávek, P.; Smutný, T.; et al. 3 beta-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3 alpha-epimer by hepatic metabolism. Journal of Steroid Biochemistry and Molecular Biology 2020, 202 (September), nestránkováno DOI: 10.1016/j.jsbmb.2020.105702.
Janoušková, M.; Vaníková, Z.; Nici, F.; Boháčová, S.; Vitovska, D.; Šanderová, H.; Hocek, M.; Krásný, L. 5-(Hydroxymethyl) uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chemical Communications 2017, 53 (99), 13253-13255 DOI: 10.1039/c7cc08053k.
Cahová, H.; Panattoni, A.; Kielkowski, P.; Fanfrlík, J.; Hocek, M. 5-Substituted Pyrimidine and 7-Substituted 7-Deazapurine dNTPs as Substrates for DNA Polymerases in Competitive Primer Extension in the Presence of Natural dNTPs. ACS Chemical Biology 2016, 11 (11), 3165-3171 DOI: 10.1021/acschembio.6b00714.
Perlíková, P.; Konečný, P.; Nauš, P.; Snášel, J.; Votruba, I.; Džubák, P.; Pichová, I.; Hajdúch, M.; Hocek, M. 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. MedChemComm 2013, 4 (11), 1497 DOI: 10.1039/c3md00232b.
Perlíková, P.; Konečný, P.; Nauš, P.; Snášel, J.; Votruba, I.; Džubák, P.; Pichová, I.; Hajdúch, M.; Hocek, M. 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. MedChemComm 2013, 4 (11), 1497 DOI: 10.1039/c3md00232b.
Bosáková, A.; Perlíková, P.; Tichý, M.; Pohl, R.; Hocek, M. 6-Aryl-4-amino-pyrimido[4,5-b]indole 2′-deoxyribonucleoside triphosphates (benzo-fused 7-deaza-dATP analogues): Synthesis, fluorescent properties, enzymatic incorporation into DNA and DNA-protein binding study. Bioorganic & Medicinal Chemistry 2016, 24 (19), 4528-4535 DOI: 10.1016/j.bmc.2016.07.054.
Perlikova, P.; Rylova, G.; Naus, P.; Elbert, T.; Tloustova, E.; Bourderioux, A.; Slavetinska, L. P.; Motyka, K.; Dolezal, D.; Znojek, P.; et al. 7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action. Molecular Cancer Therapeutics 2016, 15 (5), 922-937 DOI: 10.1158/1535-7163.MCT-14-0933.
Perlikova, P.; Rylova, G.; Naus, P.; Elbert, T.; Tloustova, E.; Bourderioux, A.; Slavetinska, L. P.; Motyka, K.; Dolezal, D.; Znojek, P.; et al. 7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action. Molecular Cancer Therapeutics 2016, 15 (5), 922-937 DOI: 10.1158/1535-7163.MCT-14-0933.
Perlikova, P.; Rylova, G.; Naus, P.; Elbert, T.; Tloustova, E.; Bourderioux, A.; Slavetinska, L. P.; Motyka, K.; Dolezal, D.; Znojek, P.; et al. 7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action. Molecular Cancer Therapeutics 2016, 15 (5), 922-937 DOI: 10.1158/1535-7163.MCT-14-0933.
Perlikova, P.; Rylova, G.; Naus, P.; Elbert, T.; Tloustova, E.; Bourderioux, A.; Slavetinska, L. P.; Motyka, K.; Dolezal, D.; Znojek, P.; et al. 7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action. Molecular Cancer Therapeutics 2016, 15 (5), 922-937 DOI: 10.1158/1535-7163.MCT-14-0933.
Kielkowski, P.; Fanfrlík, J.; Hocek, M. 7-Aryl-7-deazaadenine 2′-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA Polymerases than dATP in Competitive Incorporations. Angewandte Chemie International Edition 2014, 53 (29), 7552-7555 DOI: 10.1002/anie.201404742.
Balzarini, J.; Holy, A.; Jindrich, J. J.; Dvorakova, H.; Hao, Z.; Snoeck, R.; Herdewijn, P.; Johns, D. G.; De Clercq, E. 9-[(2RS)-3-Fluoro-2-phosphonylmethoxypropyl] derivatives of Purines - A Class of Highly Selective Antiretroviral Agents Invitro and Invivo. Proceedings of the National Aacademy of Sciences of the United States of America 1991, 88 (11), 4961-4965.
Balzarini, J.; Holy, A.; Jindrich, J. J.; Dvorakova, H.; Hao, Z.; Snoeck, R.; Herdewijn, P.; Johns, D. G.; De Clercq, E. 9-[(2RS)-3-Fluoro-2-phosphonylmethoxypropyl] derivatives of Purines - A Class of Highly Selective Antiretroviral Agents Invitro and Invivo. Proceedings of the National Aacademy of Sciences of the United States of America 1991, 88 (11), 4961-4965.
Balzarini, J.; Holy, A.; Jindrich, J. J.; Dvorakova, H.; Hao, Z.; Snoeck, R.; Herdewijn, P.; Johns, D. G.; De Clercq, E. 9-[(2RS)-3-Fluoro-2-phosphonylmethoxypropyl] derivatives of Purines - A Class of Highly Selective Antiretroviral Agents Invitro and Invivo. Proceedings of the National Aacademy of Sciences of the United States of America 1991, 88 (11), 4961-4965.
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