Publications

Brynda, J.; Fanfrlík, J.; Hadzima, M.; Hánová, I.; Horn, M.; Houštecká, R.; Lepšík, M.; Majer, P.; Mareš, M.; Mertlíková-Kaiserová, H.; et al. Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis. Journal of Medicinal Chemistry 2020, 63 (4), 1576-1596 DOI: 10.1021/acs.jmedchem.9b01351.

Dziuba, D.; Pospíšil, P.; Matyašovský, J.; Brynda, J.; Nachtigallová, D.; Rulíšek, L.; Pohl, R.; Hof, M.; Hocek, M. Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions. Chem. Sci. 2016, 7 (9), 5775-5785 DOI: 10.1039/C6SC02548J.

Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; et al. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (20), 8268-8279 DOI: 10.1021/jm500497v.

Schimer, J.; Cígler, P.; Vesely, J.; Šašková, K. Grantz; Lepšík, M.; Brynda, J.; Řezáčová, P.; Kožíšek, M.; Císařová, I.; Oberwinkler, H.; et al. Structure-Aided Design of Novel Inhibitors of HIV Protease Based on a Benzodiazepine Scaffold. Journal of Medicinal Chemistry 2012, 55 (22), 10130-10135 DOI: 10.1021/jm301249q.

Brynda, J.; Das, V.; Dvořanová, J.; Džubák, P.; Anwar, S. El; Fábry, M.; Grüner, B.; Gurska, S.; Hajdúch, M.; Havránek, M.; et al. Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX. European Journal of Medicinal Chemistry 2020, 200 (August), nestránkováno DOI: 10.1016/j.ejmech.2020.112460.

Albiñana, C. Berenguer; Brynda, J.; Fanfrlík, J.; Flieger, M.; Hodek, J.; Karlukova, E.; Konvalinka, J.; Kožíšek, M.; Machara, A.; Majer, P.; et al. Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors. European Journal of Medicinal Chemistry 2020, 208 (December), nestránkováno DOI: 10.1016/j.ejmech.2020.112754.