Heme-Containing Sensor Proteins The Group of M. Martinkova

The JPIAMR initiative (Joint Programming Initiative on Antimicrobial Resistance) was launched in 2011 with the aim of creating an international platform and coordinating national and international research programmes focused on combating growing bacterial resistance to antimicrobial agents. The Czech Republic joined this initiative in 2017.

In the 9^th call of this initiative, an international team with Czech representation succeeded with a project entitled “Prevention of Antibiotic Resistance by TARGEted Treatment of Pneumonia in Children (acronym TARGET)“. The coordinator of the project is Assoc. Prof. Marien De Jonge (Radboud University Medical Centre, Nijmegen, The Netherlands) and the Czech principal investigator is Assoc. Prof. Markéta Martínková (Faculty of Science, Charles University). From 1st March 2020, the entire team will have three years to work on the development of a new strategy to fight the antibiotic resistance of pathogenic bacteria.

Today Marketa talked about the project in the Czech Television – interviews starts at time 9:30 (a 24-hour news channel in Czech language ČT24, owned and operated by Czech Television).

Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensor AfGcHK abolishes bacterial signal transduction

Tereza Skalova, Alzbeta Lengalova, Jan Dohnalek, Karl Harlos, Peter Mihalcin, Petr Kolenko, Martin Stranav, Jan Blaha, Toru Shimizu and Markéta Martínková (2020) in Journal of Biological Chemistry DOI: 10.1074/jbc.RA119.011574

Heme: Emergent roles of heme in signal transduction, functional regulation and as catalytic centres

Shimizu T., Lengalova A., Martínek V., Martínková M. (2019)

in Chemical  Society Reviews (Royal Society of Chemistry), 48 (24), 5624-5657 DOI: 10.1039/c9cs00268e, IF2017 = 40.443

Kinetic analysis of a globin-coupled diguanylate cyclase, YddV: Effects of heme iron redox state, axial ligands, and heme distal mutations on catalysis

in Journal of Inorganic Biochemistry (Elsevier) DOI:  doi.org/10.1016/j.jinorgbio.2019.110833

• Lecture title was: Characterization and Use of Genetically Encoded Fluorescent Heme Sensors to Interrogate Heme Trafficking, Dynamics, and Signaling