Bohuslav Gaš

Charles University

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Simul

What is Simul?

Simul is a series of simulation software for electrophoresis which has been continuously developing. It simulates the movement of ions in liquid solutions in an electric field. It solves numerically a set of nonlinear partial differential equations and nonlinear algebraic equations describing the continuity of ionic movement and acid-base equilibria. Simul 6.1 is a continuation of the previous version 5. It has been designed using the latest programming tools. Its code was rewritten using Qt platform with fully standard-conformant C++ and utilizes the MSVC compiler. The computation engine has been completely redesigned in order to take full advantage of parallelization and multithreading computation. It is 5 – 15 times faster than Simul 5.

What are typical uses of Simul?

  • to simulate experimental runs and optimize separation conditions (buffers, injection),
  • to inspect or explain unusual phenomena observed in experiments: system peaks (zones), overshoots, peak distortion,
  • to inspect stacking and preconcentrating analytes, electromigration dispersion,
  • to show beginners how electrophoresis works.
  • Features of Simul 6.1

  • A mathematical model of electromigration which accounts for any number of multivalent electrolytes or ampholytes, even in the hundreds.
  • Simul 6.1 includes a database of electrophoretic mobilities and pKa constants based on Takeshi Hirokawa's tables with the data of many ions.
  • Download Simul 6.1

    Click here to download Simul 6.1 as a packed zip file.

    The program needs 64 bit Windows environment. The program is packed in the file 'Simul61Run.zip'. After downloading and unpacking, copy the directory 'Simul61Run' to the position in which you wish to have it. The package contains the program itself, example data and a user manual. Double click 'simul6.exe' to run it.

    Simul 6.1 for Linux and Mac

    Click here.

    Simul 5 Complex

    Simul 5 is a previous version of the series. Complexation mode of Simul 5 Complex enables to simulate electrophoretic separations in systems with complexation agents such as, e.g., cyclodextrins, enabling us to simulate enantioseparation in electromigration.

    Download Simul 5 Complex

    Click here to download Simul 5 Complex as a packed zip file.

    The program needs Windows environment. The program is packed in the file 'Simul_5_Complex_Release_2011.zip'. After downloading and unpacking, copy the directory 'Simul 5 Complex Release 2011' to the position in which you wish to have it. Double click the 'Simul 5.exe' to run the simulator.