Selected publications:
Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover
Authors: Tomáš Brabec, Martin Schwarzer, Katarína Kováčová, Martina Dobešová, Dagmar Schierová, Jiří Březina, Iva Pacáková, Dagmar Šrůtková, Osher Ben-Nun, Yael Goldfarb, Iva Šplíchalová, Michal Kolář, Jakub Abramson, Dominik Filipp and Jan Dobeš
Published: 2023 in Journal of Experimental Medicine
DOI: 10.1084/jem.20230194
The emerging family of RORγt+ antigen-presenting cells
Authors: Jakub Abramson*, Jan Dobeš*, Mengze Lyu*, Gregory F. Sonnenberg*
Published: 2023 in Nature Reviews Immunology
DOI: 10.1038/s41577-023-00906-5005
*all authors contributed equally
Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans
Authors: Jan Dobeš, Osher Ben-Nun, Amit Binyamin, Liat Stoler-Barak, Bergithe E. Oftedal, Yael Goldfarb, Noam Kadouri, Yael Gruper, Tal Givony, Itay Zalayat, Katarína Kováčová, Helena Böhmová, Evgeny Valter, Ziv Shulman, Dominik Filipp, Eystein S. Husebye, Jakub Abramson
Published: 2022 in Nature Immunology
DOI: 10.1038/s41590-022-01247-6
2025
Dietary influence and immune balance: Regulating CD4+ IEL responses and MHCII in the gut
Authors: Jan Dobeš, Tomáš Brabec
Published: 2025 in Mucosal Immunology
DOI: https://doi.org/10.1016/j.mucimm.2024.12.011
CUL4A exhibits tumor-suppressing role via regulation of HUWE1-mediated SMAD3 intracellular shuttling
Authors: Veronika Danek, Jolana Tureckova, Kerstin Huebner, Katharina Erlenbach-Wuensch, Petra Baranova, Jan Dobes, Jana Balounova, Michaela Simova, Vendula Novosadova, Carlos Eduardo Madureira Trufen, Michaela Prochazkova, Pavel Talacko, Karel Harant, Cyril Barinka, Inken M Beck, Regine Schneider-Stock, Radislav Sedlacek, Jan Prochazka
Published: 2025 in Cancer Letters
DOI: https://doi.org/10.1016/j.canlet.2025.217663
2024
Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects
Authors: Jan Mašek, Iva Filipovic, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Daniel V Oliveira, Anna Maria Frontino, Simona Hankeova, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, Niklas K Björkström, Martin Gregor, Jan Dobeš & Emma R Andersson
Published: 2024 in EMBO MOLECULAR MEDICINE
DOI: https://doi.org/10.1038/s44321-024-00145-8
2023
Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover
Authors: Tomáš Brabec, Martin Schwarzer, Katarína Kováčová, Martina Dobešová, Dagmar Schierová, Jiří Březina, Iva Pacáková, Dagmar Šrůtková, Osher Ben-Nun, Yael Goldfarb, Iva Šplíchalová, Michal Kolář, Jakub Abramson, Dominik Filipp and Jan Dobeš
Published: 2023 in Journal of Experimental Medicine
DOI: 10.1084/jem.20230194
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease
Authors: Yael Gruper, Anette S B Wolff, Liad Glanz, Frantisek Spoutil, Mihaela Cuida Marthinussen, Adriana Osickova, Yonatan Herzig, Yael Goldfarb, Goretti Aranaz-Novaliches, Jan Dobeš, Noam Kadouri, Osher Ben-Nun, Amit Binyamin, Bar Lavi, Tal Givony, Razi Khalaila, Tom Gome, Tomáš Wald, Blanka Mrazkova, Carmel Sochen, Marine Besnard, Shifra Ben-Dor, Ester Feldmesser, Elisaveta M Orlova, Csaba Hegedűs, István Lampé, Tamás Papp, Szabolcs Felszeghy, Radislav Sedlacek, Esti Davidovich, Noa Tal, Dror S Shouval, Raanan Shamir, Carole Guillonneau, Zsuzsa Szondy, Knut E A Lundin, Radim Osicka, Jan Prochazka, Eystein S Husebye, Jakub Abramson
Published: 2023 in Nature
DOI: 10.1038/s41586-023-06776-0
Thymic mimetic cells function beyond self-tolerance
Authors: Tal Givony, Dena Leshkowitz, Diana Del Castillo, Shir Nevo, Noam Kadouri, Bareket Dassa, Yael Gruper, Razi Khalaila, Osher Ben-Nun, Tom Gome, Jan Dobeš, Shifra Ben-Dor, Merav Kedmi, Hadas Keren-Shaul, Rebecca Heffner-Krausz, Ziv Porat, Ofra Golani, Yoseph Addadi, Ori Brenner, David D. Lo, Yael Goldfarb, Jakub Abramson
Published: 2023 in Nature
DOI: 10.1038/s41586-023-06512-8
The emerging family of RORγt+ antigen-presenting cells
Authors: Jakub Abramson*, Jan Dobeš*, Mengze Lyu*, Gregory F. Sonnenberg*
Published: 2023 in Nature Reviews Immunology
DOI: 10.1038/s41577-023-00906-5005
*all authors contributed equally
IL-17 driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum
Authors: Tomas Brabec, Matouš Vobořil, Dagmar Schierova, Evgeny Valter, Iva Splichalova, Jan Dobeš, Jiri Brezina, Martina Dobesova, Aigerim Aidarova, Martin Jakubec, Jasper Manning, Richard Blumberg, Ari Waissman, Michal Kolar, Jan Kubovciak, Dagmar Srutkova, Tomas Hudcovic, Martin Schwarzer, Eva Fronkova, Tereza Pinkasova, Petr Jabandziev, Dominik Filipp
Published: 2023 in Mucosal Immunology
DOI: 10.1016/j.mucimm.2023.01.005
2022
Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans
Authors: Jan Dobeš, Osher Ben-Nun, Amit Binyamin, Liat Stoler-Barak, Bergithe E. Oftedal, Yael Goldfarb, Noam Kadouri, Yael Gruper, Tal Givony, Itay Zalayat, Katarína Kováčová, Helena Böhmová, Evgeny Valter, Ziv Shulman, Dominik Filipp, Eystein S. Husebye, Jakub Abramson
Published: 2022 in Nature Immunology
DOI: 10.1038/s41590-022-01247-6
Transcriptional regulation of the thymus master regulator Foxn1
Authors: Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben Dor, Golda Damari, Bareket Dassa, Jan Dobes, Dieter Weichenhan, Marion Bähr, Michelle Paulsen, Rebecca Haffner-Krausz, Marcus A Mall, Christoph Plass, Yael Goldfarb, Jakub Abramson
Published: 2022 in Science Immunology
DOI: 10.1126/sciimmunol.abn8144
A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer
Authors: Matouš Vobořil, Jiří Březina, Tomáš Brabec, Jan Dobeš, Ondřej Ballek, Martina Dobešová, Jasper Manning, Richard S Blumberg, Dominik Filipp
Published: 2022 in Elife
DOI: 10.7554/eLife.71578
2021
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation
Authors: Yael Goldfarb, Tal Givony, Noam Kadouri, Jan Dobeš, Cristina Peligero-Cruz, Itay Zalayat, Golda Damari, Bareket Dassa, Shifra Ben-Dor, Yael Gruper, Bergithe E Oftedal, Eirik Bratland, Martina M Erichsen, Amund Berger, Ayelet Avin, Shir Nevo, Uku Haljasorg, Yael Kuperman, Adi Ulman, Rebecca Haffner-Krausz, Ziv Porat, Ulus Atasoy, Dena Leshkowitz, Eystein S Husebye, Jakub Abramson
Published: 2021 in Journal of Experimental Medicine
DOI: 10.1084/jem.20201076
2020
IL18 signaling promotes homing of mature Tregs into the thymus
Authors: Cristina Peligero-Cruz, Tal Givony, Arnau Sebé-Pedrós, Jan Dobeš, Noam Kadouri, Shir Nevo, Francesco Roncato, Ronen Alon, Yael Goldfarb, Jakub Abramson
Published: 2020 in Elife
DOI: 10.7554/eLife.58213
Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation
Authors: Matouš Vobořil, Tomáš Brabec, Jan Dobeš, Iva Šplíchalová, Jiří Březina, Adéla Čepková, Martina Dobešová, Aigerim Aidarova, Jan Kubovčiak, Oksana Tsyklauri, Ondřej Štěpánek, Vladimír Beneš, Radislav Sedláček, Ludger Klein, Michal Kolář, Dominik Filipp
Published: 2020 in Nature Communications
DOI: 10.1038/s41467-020-16081-3
2019
Aire-expressing ILC3-like cells in the lymph node display potent APC features
Authors: Tomoyoshi Yamano, Jan Dobeš, Matouš Vobořil, Madlen Steinert, Tomáš Brabec, Natalia Ziętara, Martina Dobešová, Caspar Ohnmacht, Martti Laan, Part Peterson, Vladimir Benes, Radislav Sedláček, Rikinari Hanayama, Michal Kolář, Ludger Klein, Dominik Filipp
Published: 2019 in Journal of Experimental Medicine
DOI: 10.1084/jem.20181430
Enteric α-defensins on the verge of intestinal immune tolerance and inflammation
Authors: Dominik Filipp, Tomáš Brabec, Matouš Vobořil, Jan Dobeš
Published: 2019 in Seminars in Cell & Developmental Biology
DOI: 10.1016/j.semcdb.2018.01.007
2018-2012
A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire
Authors: Jan Dobeš, Frank Edenhofer, Matouš Vobořil, Tomáš Brabec, Martina Dobešová, Adéla Čepková, Ludger Klein, Klaus Rajewsky, Dominik Filipp
Published: 2018 in European Journal of Immunology
DOI: 10.1002/eji.201747267
Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse
Authors: Vitezslav Kriz, Michaela Krausova, Petra Buresova, Jan Dobes, Dusan Hrckulak, Olga Babosova, Jiri Svec, Vladimir Korinek
Published: 2017 in Transgenic Research
DOI: 10.1007/s11248-017-0027-0
Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric α-Defensins
Authors: Jan Dobeš, Aleš Neuwirth, Martina Dobešová, Matouš Vobořil, Jana Balounová, Ondřej Ballek, Jan Lebl, Antonella Meloni, Kai Krohn, Nicolas Kluger, Annamari Ranki, Dominik Filipp
Published: 2015 in Gastroenterology
DOI: 10.1053/j.gastro.2015.05.009
HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis
Authors: Lucie Janeckova, Vendula Pospichalova, Bohumil Fafilek, Martina Vojtechova, Jolana Tureckova, Jan Dobes, Marion Dubuissez, Dominique Leprince, Nikol Baloghova, Monika Horazna, Adela Hlavata, Jitka Stancikova, Eva Sloncova, Katerina Galuskova, Hynek Strnad, Vladimir Korinek
Published: 2015 in Molecular Cancer Research
DOI: 10.1158/1541-7786.MCR-15-0033
NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling
Authors: Jitka Stancikova, Michaela Krausova, Michal Kolar, Bohumil Fafilek, Jiri Svec, Radislav Sedlacek, Magdalena Neroldova, Jan Dobes, Monika Horazna, Lucie Janeckova, Martina Vojtechova, Martin Oliverius, Milan Jirsa, Vladimir Korinek
Published: 2015 in Cellular Signalling
DOI: 10.1016/j.cellsig.2014.11.008
Eosinophils from patients with type 1 diabetes mellitus express high level of myeloid alpha-defensins and myeloperoxidase
Authors: Aleš Neuwirth, Jan Dobeš, Jana Oujezdská, Ondřej Ballek, Martina Benešová, Zdeněk Sumník, Jana Včeláková, Stanislava Koloušková, Barbora Obermannová, Michal Kolář, Kateřina Stechová, Dominik Filipp
Published: 2012 in Cellular Immunology
DOI: 10.1016/j.cellimm.2011.12.001