RNDr. Komrsková (Hortová), Ph.D.
Position
Researcher/Lecturer
Contact Information
Division of Animal Evolutionary Biology, Department of Zoology
Faculty of Science, Charles University
Viničná 7, 128 44 Praha, Czech Republic
Room No.: 225
Phone: +420–22195 1852
E-mail: katerina.komrskova[a]natur.cuni.cz
Group of Reproductive Biology
Institute of Biotechnology, Czech Academy of Sciences, BIOCEV
Prumyslová 595, 252 50 Vestec, Czech Republic
Phone: +420–32587 3799
E-mail: katerina.komrskova[a]ibt.cas.cz
http://www.ibt.cas.cz
Research Group
Research Interests
Sperm-egg interaction and fusion; Sperm preparation for fertilization (capacitation and acrosome reaction);
epigenetic regulation of early embryogenesis, epigenetic markers associated with human infertility;
spermatogenesis and sperm parameters assessment after endocrine disruptor challenge, genomic
and proteomic approach.
Grants
Czech Health Research Council:
NU20-03-00309 Monitoring of fertility and testicular tissue status in testicular cancer patients depending on their therapy. 2020-2023.
Czech Science Foundation:
20-20217J The sperm LINC complex: The LINK between chromatin integrity, sperm motility and male fertility. 2020-2022.
TACR Zeta:
TJ02000219 Novel tools for diagnostics and improvement of fertilization ability of sperm. 2019-2020.
Czech Science Foundation:
18-11275S Monitoring of protein network dynamics during sperm-egg membrane interaction. 2018-2020.
Czech Science Foundation:
18-14325S The genetic basis of species origin: What can we learn from organisms with female heterogamety? 2018-2020.
Teaching
General Biology of Animals (MB170P85)
Physiology of gametes and fertilization (MB151P118)
Selected Publications
Frolikova M, Manaskova-Postlerova P, Cerny J, Jankovicova J, Simonik O, Pohlova A, Secova P, Antalikova J, Dvorakova-Hortova K (2018) CD9 and CD81 Interaction and their Structure Modelling in Sperm Prior to Fertilization. Int J Mol Sci. 19(4). Pii: E1236. Doi: 10.3390/Ijms19041236.
Frolikova M, Sebkova N, Ded L, Dvorakova-Hortova K (2016)
Characterization of CD46 and beta 1 integrin dynamics during sperm acrosome reaction. Scientific Reports, 6: 33714.
Sebkova N, Cerna M, Ded L, Peknicova J and Dvorakova-Hortova K (2012). The slower the
better: how sperm capacitation and acrosome reaction is modified in the presence of estrogens.
Reproduction, 143: 297-307.
Johnson PM, Clift LE, Andrlikova P, Jursova M, Flanagan BF, Cummerson JA and Stopka P and
Dvorakova-Hortova K (2007). Rapid sperm acrosome reaction in the absence of acrosomal CD46
expression in promiscuous field mice (Apodemus). Reproduction, 134: 739-747.
Moore H, Dvorakova K, Jenkins N and Breed W (2002). Exceptional sperm cooperation in the
wood mouse. Nature, 418: 174-177.