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Two New Collaborative Papers Reveal Mechanisms of Siglec-7 Ligand Binding

Our laboratory has contributed to two newly published studies investigating the role of Siglec-7, an inhibitory receptor expressed on natural killer (NK) cells, in immune regulation through its interactions with glycan ligands in both cancer and bacterial infection contexts. In the first study, researchers examined how Siglec-7 recognises the tumour-associated ganglioside GD3, a disialylated glycosphingolipid […]

Our Article Featured on Bluesky Account of the Faculty of Science

We’re proud to share that our recent publication has been highlighted on the official Bluesky account of the Faculty of Science, Charles University! The post features our article highlighting the first full mapping of both N- and O-linked glycan structures on the immune receptor NKp46. Our findings reveal how these glycans are essential for recognising […]

A new paper has been published in cooperation with an Italian laboratory of prof. Alba Silipo!

Our PhD student Celeste Abreu is the first author of a new paper published in the International Journal of Biological Macromolecules titled:“Insights into stability, dimerisation, and ligand binding properties of Siglec-7: Isotope labelling in HEK293 cells for protein characterisation by NMR spectroscopy” 3D model of disialylated pentaose bound to Siglec-7_CRD (PDB 2HRL) The study reports […]

GA CU Grant Awarded to Our Lab

BSc. Jakub Jeníček from our laboratory has been awarded a Grant Agency of Charles University project to support our ongoing research into NK cell receptors’ structural and functional interactions with their ligands. This funding will enable us to investigate the molecular mechanisms of immune recognition further, focusing on the interaction of the rat NK receptor […]