We are proud to share the latest article co-authored by our lab member Ondřej Skořepa, titled:“Resolving the structural basis of therapeutic antibody function in cancer immunotherapy with RESI”, published in Nature Communications! This study uncovers how the nanoscale organization of CD20 receptors determines the functional differences between Type I and Type II therapeutic anti-CD20 antibodies […]
Our laboratory has contributed to two newly published studies investigating the role of Siglec-7, an inhibitory receptor expressed on natural killer (NK) cells, in immune regulation through its interactions with glycan ligands in both cancer and bacterial infection contexts. In the first study, researchers examined how Siglec-7 recognises the tumour-associated ganglioside GD3, a disialylated glycosphingolipid […]
We’re proud to share that our recent publication has been highlighted on the official Bluesky account of the Faculty of Science, Charles University! The post features our article highlighting the first full mapping of both N- and O-linked glycan structures on the immune receptor NKp46. Our findings reveal how these glycans are essential for recognising […]
We are proud to share the latest publication from our lab member, Shiva Nejadebrahim, titled “Multiple O- and an N-glycosylation of the stalk region of the NK cell activation receptor NKp46 mediates its interaction with the Candida glabrata epithelial adhesin 1″. This study provides, for the first time, a comprehensive glycosylation profile of the NK […]
Our PhD student Celeste Abreu is the first author of a new paper published in the International Journal of Biological Macromolecules titled:“Insights into stability, dimerisation, and ligand binding properties of Siglec-7: Isotope labelling in HEK293 cells for protein characterisation by NMR spectroscopy” 3D model of disialylated pentaose bound to Siglec-7_CRD (PDB 2HRL) The study reports […]
BSc. Jakub Jeníček from our laboratory has been awarded a Grant Agency of Charles University project to support our ongoing research into NK cell receptors’ structural and functional interactions with their ligands. This funding will enable us to investigate the molecular mechanisms of immune recognition further, focusing on the interaction of the rat NK receptor […]