Publications

Selected papers:

2024

  • Sergunin A., Vávra J., Pašek D., Shimizu T., Martínková M. (2024) Multiple roles for iron in microbial physiology: bacterial oxygen sensing by heme-based sensors,  Advances in Microbial Physiology 85: accepted. ISBN: 9780443295423, eBook ISBN: 9780443295430

2023

  • Vávra J., Sergunin A., Pompach P., Savchenko D., Hraníček J., Šloufová I., Shimizu T., Martínková M. (2023) Characterization of the interaction between the tumour suppressor p53 and heme and its role in the protein conformational dynamics studied by various spectroscopic techniques and hydrogen/deuterium exchange coupled with mass spectrometry, J. Inorg. Biochem. 243: 112180. doi.org/10.1016/j.jinorgbio.2023.112180
  • Vávra J., Sergunin A., Farná A., Ovad T., Shimizu T., Martínková M. (2023) Is ATP the only nucleoside triphosphate among ATP, CTP, GTP, and UTP to have a role in kinase catalysis of heme-regulated inhibitor toward eIF2α during lung cancer development? Catalysts 13: 281. https://doi.org/10.3390/catal13020281
  • Vávra J., Sergunin A., Shimizu T., Martínková M. (2023) Monitoring the kinase activity of heme-based oxygen sensors and its dependence on O2 and other ligands using Phos-tag electrophoresis, Methods in Molecular Biology, Oxygen Sensing: Methods and Protocols, 2648: 63-73 10.1007/978-1-0716-3080-8_5
  • VávraJ., Sergunin A., Stráňava M., Kádek A., Shimizu T., Man P., Martínková M. (2023) Hydrogen/deuterium exchange mass spectrometry of heme-based oxygen sensor proteins, Methods in Molecular Biology, Oxygen Sensing: Methods and Protocols, 2648: 99-122 10.1007/978-1-0716-3080-8_8

2022

  • Vávra J., Sergunin A., Jeřábek P., Shimizu T., Martínková M. (2022) Signal transduction mechanisms in heme-based globin-coupled oxygen sensors with a focus on a histidine kinase AfGcHK and a diguanylate cyclase (YddV or EcDosC), Biol. Chem. 403: 1031-1042. 10.1515/hsz-2022-0185
  • CZ: Martínková M. (2022) Nová role hemu ve zdraví a nemoci – hemové senzorové protein (EN: The Novel Role of Heme in Health and Diseases – Heme-Containing Sensor Proteins). Chemické listy 116: (3), 163–171. doi.org/10.54779/chl20220163

2020

  • Skalova T., Lengalova A., Dohnálek J., Harlos K., Mihalcin P., Kolenko P., Stranava M., Bláha J., Shimizu T., Martínková M. (2020) Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensor AfGcHK abolishes bacterial signal transduction, J. Biol. Chem. 295: 1587–1597 10.1074/jbc.RA119.011574

2019

  • Shimizu T., Lengalova A., Martínek V., Martínková M. (2019) Heme: Emergent roles of heme in signal transduction, functional regulation and as catalytic centres, Chem. Soc. Rev., 48: 5624-5657 doi.org/10.1039/c9cs00268e
  • Lengalova A., Fojtikova-Proskova V, Vavra J, Martínek V, Stranava M, Shimizu T, Martinkova M (2019) Kinetic Analysis of a Globin-Coupled Diguanylate Cyclase, YddV: Effects of Heme Iron Redox State, Axial Ligands, and Heme Distal Mutations on Catalysis, Journal of Inorganic Biochemistry, 201: 110833.
  • Indra R, Černá T, Heger Z, Hraběta J, Wilhelm M, Dostálová S, Lengálová A, Martínková M, Adam V, Eckschlager T, Schmeiser HH, Arlt VM, Stiborová M (2019) Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells, Toxicology, 419: 40–54.

2018

  • Stiborová M, Dračínská H, Bořek-Dohalská L, Klusoňová Z, Holecová J, Martínková M, Schmeiser HH, Arlt VM (2018) Exposure to Endocrine Disruptors 17alpha-Ethinylestradiol and Estradiol Influences Cytochrome P450 1A1-Mediated Genotoxicity of Benzo[a]Pyrene and Expression of This Enzyme in Rats, Toxicology, 400–401: 48–56

2017

  • Stranava M, Man P, Skálová T, Kolenko P, Blaha J, Fojtikova V, Martínek V, Dohnálek J, Lengalova A, Rosůlek M, Shimizu T, Martinkova M (2017) Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction, J Biol Chem,  292: 20921-20935
  • Mináriková M, Fojtikova V, Vyskočilová E, Sedláček J, Šikut M, Borek-Dohalska L, Stiborová M, Martinkova M (2017) The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: a comparative study, Environ Toxicol Phar 52: 214-220

2016

  • Fojtikova V, Bartosova M, Man P, Stranava M, Shimizu T, Martinkova M (2016) Effects of hydrogen sulfide on the heme coordination structure and catalytic activity of the globin-coupled oxygen sensor AfGcHK, Biometals 29: 715-729
  • Stranava M, Martinek V, Man P, Fojtikova V, Kavan D, Vaněk O, Shimizu T, Martinkova M (2016) Structural Characterization of the Heme-based Oxygen Sensor, AfGcHK, its Interactions with the Cognate Response Regulator, and their Combined Mechanism of Action in a Bacterial Two-component Signaling System. Proteins, 84: 1375-89
  • Kuipers K, Gallay C, Martínek V, Rohde M, Martínková M, van der Beek SL, Jong WS, Venselaar H, Zomer A, Bootsma H, Veening JW, de Jonge MI (2016) Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae. Mol Microbiol 101: 12-26
  • Lambry J-Ch, Stranava M, Lobato L, Martinkova M, Shimizu T, Liebl U, Vos MH (2016) Ultrafast Spectroscopy Evidence for Picosecond Ligand Exchange at the Binding Site of a Heme Protein: Heme-based Sensor YddV. J Phys Chem Lett 7: 69–74

2015

  • Fojtikova V, Stranava M, Vos M H, Liebl U,  Hraníček J, Kitanishi K, Shimizu T, Martinkova M (2015) Kinetic Analysis of a Globin-coupled Histidine Kinase, AfGcHK: Effects of the Heme Iron Complex, Response Regulator and Metal Cations on Autophosphorylation Activity. Biochemistry 54: 5017–5029
  • Pavlou A, Martínková M, Shimizu T, Kitanishi K, Stranava M, Loullis A, Pinakoulaki E (2015)  Probing the ligand recognition and discrimination environment of the globin-coupled oxygen sensor protein YddV by FTIR and time-resolved step-scan FTIR spectroscop.Phys Chem Chem Phys 17: 17007-17015
  • Yan F, Fojtikova V, Man P, Stráňava M, Martínková M, Du Y, Huang D, Shimizu T (2015)  Catalytic Enhancement of the Heme-based Oxygen-Sensing Phosphodiesterase EcDOS by Hydrogen Sulfide Is Caused by Changes in Heme Coordination Structure, BioMetals 28: 637-652
  • Shimizu T, Yan F, Huang D, Stráňava M, Bartošová M, Fojtíková V, Martínková M (2015) Molecular Characteristics of Heme-based Gas (O2, NO and CO) Sensors. Chem Rev 115: 6491−6533

2014

  • Anzenbacher P, Marchal S, Palacký J, Anzenbacherová E, Domaschke T, Lange R, Shimizu T, Kitanishi K, Stranava M, Stiborová M, Martinkova M (2014) Pressure effects reveal that heme iron-redox change significantly affects the protein flexibility of the heme domains of heme-based oxygen sensors, Ec DOS and YddV. FEBS J 281: 5208–5219
  • Stranava M, Martínková M, Stiborová M, Man P, Kitanishi K, Muchová L, Vítek L, Martínek V, Shimizu T (2014) Introduction of water into the heme distal side by Leu65 mutations of an oxygen sensor, YddV, generates verdoheme and carbon monoxide, exerting the heme oxygenase reaction. J Inorg Biochem 140: 29-38

2013

  • Du Y, Liu G, Yan, Y Huang D, Luo W, Martinkova M, Man P, Shimizu T (2013) Conversion of a Heme-based Oxygen Sensor to a Heme Oxygenase by Hydrogen Sulfide: Effects of Mutations in the Heme Distal Side of a Heme-based  Oxygen Sensor Phosphodiesterase (Ec DOS). BioMetals 26: 839–852
  • Martinkova M, Kitanishi K, and Shimizu T (2013) Heme-Based Globin-Coupled Oxygen Sensors: Linking Oxygen Binding to Functional Regulation of Diguanylate Cyclase, Histidine Kinase and Methyl-accepting Chemotaxis. J Biol Chem 288: 27702–27711