Welcome to the Laboratory of Structural Biochemistry
of Immune Recognition
About us
Our research group is interested in cell-cell recognition processes, i.e., how the immune cells, for example, NK cells, recognize by receptors expressed on their surface the target proteins expressed on the surface of healthy cells or of the tumour, virally infected, or stressed cells. We are interested firstly in the structure-function relationship, using a wide range of modern methods of research of protein structure, their properties and interactions, and secondly, how we could transfer the gained knowledge into a practical level, besides other things by designing artificial protein constructs which would help the immune cells to recognize better and eliminate the target cells.
Our research
News
Our Work Featured on the Cover of JACS Au
We are pleased to share that a new collaborative publication “Engineering a…
Siglec-7 and Immune Evasion – Our Research Featured on the Faculty Website
Our team’s research has been highlighted in the news section of the…
Group leader Ondřej Vaněk presents at the Junior Faculty Conference 2025
On 26 September 2025, the first-ever Junior Faculty Conference 2025 at the…
New paper is out! Nanoscale insights into therapeutic antibody function with RESI microscopy
We are proud to share the latest article co-authored by our lab…
Two New Collaborative Papers Reveal Mechanisms of Siglec-7 Ligand Binding
Our laboratory has contributed to two newly published studies investigating the role…
Our Article Featured on Bluesky Account of the Faculty of Science
We’re proud to share that our recent publication has been highlighted on…
New paper is out! Find about NKp46 glycosylation and Candida glabrata interaction
We are proud to share the latest publication from our lab member,…
A new paper has been published in cooperation with an Italian laboratory of prof. Alba Silipo!
Our PhD student Celeste Abreu is the first author of a new…
GA CU Grant Awarded to Our Lab
BSc. Jakub Jeníček from our laboratory has been awarded a Grant Agency…
A new four-year Czech-US project granted!
A new international project, titled Exploiting Molecular Mechanisms of Natural Killer Cell…
New Czech Science Foundation project on structural immunology of NK cell recognition
A new project, called Structural Immunology of NK Cell Recognition: From Tumour…
Master’s thesis nominated for the Rector’s award!
In 2024, several Master’s and Bachelor’s theses from our laboratory were successfully…
Our research featured on the JCI Insight journal’s cover
Our research has been featured on the front cover of the JCI…
Ondřej Skořepa and Celeste Abreu at the 48th FEBS Congress
Postdoctoral researcher Ondřej Skořepa and PhD student Celeste Abreu from our laboratory…
Invited talk at the 2nd Immunotherapy Day
On 30th May 2024, our research group leader Ondřej Vaněk presented at…
Our students at the Instruct Biennial Conference in Portugal
Two of our promising young students, Celeste Abreu and Yuri Dubanych, have…
Our group leader presents at XX. Discussions in Structural Molecular Biology
From 21–23 March 2024, the annual XX. Discussions in Structural Molecular Biology…
PF 2024
The Laboratory of Structural Biochemistry of Immune Recognition wishes you a prosperous…
Czech Science Foundation Postdoc Individual Fellowship Granted to Ondřej Skořepa
The Czech Science Foundation (GA CR) has awarded funding to a POSTDOC…
Our students at XXII. Meeting of Biochemists and Molecular Biologists!
The XXII. Meeting of Biochemists and Molecular Biologists, held on November 14-15,…
Czech Science Foundation Grant Fuels Cutting-Edge Research on NK Cell Immune Synapses
The Czech Science Foundation (GA CR) has awarded funding to an international…
Our grant project has been awarded with an “excellent” grade by the Czech Science Foundation!
Two new projects have been approved by the Grant Agency of Charles University!
Congratulations to Maxmilián Hejl and Nadezda Bragina, two of our Master’s students…
Head of our laboratory as an Instruct-ERIC Webinar invited speaker!
Ondřej Vaněk, head of the laboratory, spoke at the 25th Instruct-ERIC Webinar…
Our article in the Instruct-ERIC Scientific Highlights!
Our research team, together with the team of Institute of Biotechnology of…
PF 2023
The Laboratory of Structural Biochemistry of Immune Recognition wishes you a structured…
We are back! Our laboratory at the XXI. Meeting of Biochemists and Molecular Biologists in Brno
The annual XXI. Meeting of Biochemists and Molecular Biologists took place on…
A Master’s student can also participate!
A student of our laboratory has been accepted to attend the Joint…
Our new article is featured on the Faculty of Science website!
From the atom to NK cell: the story of an unexpected protein…
A new publication in Nature Communications is out!
Congratulations to the team of researchers from our laboratory! The research directed…
Our student presenting a poster at Instruct Biennial Structural Biology Conference
A master’s student of our laboratory, Kristýna Pazderová, has been accepted to…
Presenting our work at INNOGLY Annual Meeting 2022
Three laboratory members have been accepted to present their work at the…
Defence of Doctoral thesis, another success
Yet another success for the Laboratory of Structural Biochemistry of Immune Recognition!…