Thesis description: Sigma factors help bacterial RNA polymerase recognize promoters and initiate transcription. One of the sigma factors in mycobacteria, sigma B, is capable of forming large complexes with RNA polymerase in vitro. However, RNA polymerase in these complexes is inactive and unable to participate in transcription. The aim of this study is to determine whether these RNA polymerase complexes are present in bacteria and how their assembly is regulated. Recently, we discovered an RNA molecule that binds to sigma B and could regulate the assembly of these complexes. As a model organism, we use the non-pathogenic Mycobacterium smegmatis. Literature: https://www.nature.com/articles/s41467-023-36113-y https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae081/7606967?login=false
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Regulation of transcription in bacteria
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