Publications

Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; et al. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (20), 8268-8279 DOI: 10.1021/jm500497v.

Bouřa, E.; Dejmek, M.; Chalupská, D.; Klíma, M.; Matoušová, M.; Mertlíková-Kaiserová, H.; Misehe, M.; Nencka, R.; Šála, M. Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold. Bioorganic and Medicinal Chemistry Letters 2022, 76 (November), nestránkováno.

Brynda, J.; Das, V.; Dvořanová, J.; Džubák, P.; Anwar, S. El; Fábry, M.; Grüner, B.; Gurska, S.; Hajdúch, M.; Havránek, M.; et al. Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX. European Journal of Medicinal Chemistry 2020, 200 (August), nestránkováno DOI: 10.1016/j.ejmech.2020.112460.

Brynda, J.; Das, V.; Dvořanová, J.; Džubák, P.; Anwar, S. El; Fábry, M.; Grüner, B.; Gurska, S.; Hajdúch, M.; Havránek, M.; et al. Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX. European Journal of Medicinal Chemistry 2020, 200 (August), nestránkováno DOI: 10.1016/j.ejmech.2020.112460.

Brynda, J.; Das, V.; Dvořanová, J.; Džubák, P.; Anwar, S. El; Fábry, M.; Grüner, B.; Gurska, S.; Hajdúch, M.; Havránek, M.; et al. Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX. European Journal of Medicinal Chemistry 2020, 200 (August), nestránkováno DOI: 10.1016/j.ejmech.2020.112460.

Benkovics, G.; Hodek, O.; Havlikova, M.; Bosakova, Z.; Coufal, P.; Malanga, M.; Fenyvesi, E.; Darcsi, A.; Beni, S.; Jindřich, J. Supramolecular structures based on regioisomers of cinnamyl-α-cyclodextrins – new media for capillary separation techniques. Beilstein Journal of Organic Chemistry 2016, 12, 97-109 DOI: 10.3762/bjoc.12.11.

Doleželová, E.; Downey, A. Michael; Hocek, M.; Nguyen, V. Hai; Pohl, R.; Rožánková, S.; Slapničková, M.; Tichý, M.; Tloušťová, E.; Zíková, A. Synthesis and anti-trypanosomal activity of 3'-fluororibonucleosides derived from 7-deazapurine nucleosides. Bioorganic and Medicinal Chemistry Letters 2021, 40 (May 15 2021), nestránkováno.

Doleželová, E.; Downey, A. Michael; Hocek, M.; Nguyen, V. Hai; Pohl, R.; Rožánková, S.; Slapničková, M.; Tichý, M.; Tloušťová, E.; Zíková, A. Synthesis and anti-trypanosomal activity of 3'-fluororibonucleosides derived from 7-deazapurine nucleosides. Bioorganic and Medicinal Chemistry Letters 2021, 40 (May 15 2021), nestránkováno.

Doleželová, E.; Džubák, P.; Gurská, S.; Hajdúch, M.; Hocek, M.; Krajczyk, A.; Milisavljević, N.; Perlíková, P.; Slavětínská, L. Poštová; Slapničková, M.; et al. Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides. ACS Infectious Diseases 2021, 7 (4), 917-926.

Doleželová, E.; Džubák, P.; Gurská, S.; Hajdúch, M.; Hocek, M.; Krajczyk, A.; Milisavljević, N.; Perlíková, P.; Slavětínská, L. Poštová; Slapničková, M.; et al. Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides. ACS Infectious Diseases 2021, 7 (4), 917-926.

Eignerová, B.; Sedlák, D.; Dračínský, M.; Bartůněk, P.; Kotora, M. Synthesis and Biochemical Characterization of a Series of 17α-Perfluoroalkylated Estradiols as Selective Ligands for Estrogen Receptor α. Journal of Medicinal Chemistry 2010, 53 (19), 6947-6953 DOI: 10.1021/jm100563h.

Nauš, P.; Caletková, O.; Perlíková, P.; Slavětínská, L. Poštová; Tloušťová, E.; Hodek, J.; Weber, J.; Džubák, P.; Hajdúch, M.; Hocek, M. Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4′-C-methylribonucleosides. Bioorganic & Medicinal Chemistry 2015, 23 (23), 7422-7438 DOI: 10.1016/j.bmc.2015.10.040.

Bartova, K.; Džubák, P.; Fleuti, M. Heidi; Gurska, S.; Hajdúch, M.; Hocek, M.; Pavliš, P.; Slavětínská, L. Poštová; Tichý, M.; Tloušťová, E. Synthesis and Biological Profiling of Pyrazolo-Fused 7-Deazapurine Nucleosides. Journal of Organic Chemistry 2020, 85 (16), 10539-10551 DOI: 10.1021/acs.joc.0c00928.

Klečka, M.; Slavětínská, L. Poštová; Tloušťová, E.; Džubák, P.; Hajdúch, M.; Hocek, M. Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides. Med. Chem. Commun. 2015, 6 (4), 576-580 DOI: 10.1039/C4MD00492B.

Sedlák, D.; Eignerová, B.; Dračínský, M.; Janoušek, Z.; Bartůněk, P.; Kotora, M. Synthesis and evaluation of 17α-(carboranylalkyl)estradiols as ligands for estrogen receptors α and β. Journal of Organometallic Chemistry 2013, 747, 178-183 DOI: 10.1016/j.jorganchem.2013.06.013.

Janková, Š.; Dračínský, M.; Císařová, I.; Kotora, M. Synthesis and Rearrangement of Dewar Benzenes Into Biaryls: Experimental Evidence for Conrotatory Ring Opening. European Journal of Organic Chemistry 2008, 2008 (1), 47-51 DOI: 10.1002/ejoc.200700916.

Nauš, P.; Caletková, O.; Konečný, P.; Džubák, P.; Bogdanová, K.; Kolář, M.; Vrbková, J.; Slavětínská, L.; Tloušt’ová, E.; Perlíková, P.; et al. Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides. Journal of Medicinal Chemistry 2014, 57 (3), 1097-1110 DOI: 10.1021/jm4018948.

Sabat, N.; Nauš, P.; Matyašovský, J.; Dziuba, D.; Slavětínská, L.; Hocek, M. Synthesis of Fluorescent 2-Substituted 6-(Het)aryl-7-deazapurine Bases {4-(Het)aryl-pyrrolo[2,3-d]pyrimidines} by Aqueous Suzuki–Miyaura Cross-Coupling Reactions. Synthesis 2016, 48 (07), 1029-1045 DOI: 10.1055/s-0035-1561287.

Eignerová, B.; Slavíková, B.; Buděšínský, M.; Dračínský, M.; Klepetářová, B.; Št’astná, E.; Kotora, M. Synthesis of Fluorinated Brassinosteroids Based on Alkene Cross-Metathesis and Preliminary Biological Assessment. Journal of Medicinal Chemistry 2009, 52 (18), 5753-5757 DOI: 10.1021/jm900495f.

Jindrich, J.; Dvorakova, H.; Holy, A. Synthesis of Isomeric N-(3-Fluoro-2-hydroxypropyl) and N-(2-Fluoro-3-hydroxypropyl) Derivatives of Purine and Pyrimidine-bases. Collection of Czechoslovak Chemical Communications 1992, 57 (7), 1466-1482.

Jindrich, J.; Holy, A.; Dvorakova, H. Synthesis of N-(3-Fluoro-2-phophonomethoxypropyl) (FPMP) Derivatives of Heterocyclic Bases. Collection of Czechoslovak Chemical Communications 1993, 58 (7), 1645-1667.

A. Downey, M.; Pohl, R.; Roithová, J.; Hocek, M. Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism. Chemistry-a European Journal 2017, 23 (16), 3910-3917 DOI: 10.1002/chem.201604955.

Eignerová, B.; Janoušek, Z.; Dračínský, M.; Kotora, M. Synthesis of Perfluoroalkylated Carboranes by Cross-Metathesis of Allylcarboranes and Perfluoroalkylpropenes. Synlett 2010, 2010 (06), 885-888 DOI: 10.1055/s-0029-1219546.

Džubák, P.; Gurska, S.; Hajdúch, M.; Hocek, M.; Pavliš, P.; Pohl, R.; Tichý, M.; Yang, C. Synthesis, Photophysical Properties, and Biological Profiling of Benzothieno-Fused 7-Deazapurine Ribonucleosides. Journal of Organic Chemistry 2020, 85 (12), 8085-8101 DOI: 10.1021/acs.joc.0c00927.

Dhami, K.; Malyshev, D. A.; Ordoukhanian, P.; Kubelka, T.; Hocek, M.; Romesberg, F. E. Systematic exploration of a class of hydrophobic unnatural base pairs yields multiple new candidates for the expansion of the genetic alphabet. Nucleic Acids Research 2014, 42 (16), 10235-10244 DOI: 10.1093/nar/gku715.